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Total 24 results found since Jan 2013.

Early versus late injections of Botulinumtoxin type A in post-stroke spastic movement disorder: A literature review
Toxicon. 2023 May 3:107150. doi: 10.1016/j.toxicon.2023.107150. Online ahead of print.ABSTRACTPost-stroke spastic movement disorder (PS-SMD) is one of the main causes of severe disability in the chronic phase after stroke. The prevalence of SMD rises up with time after stroke to more than 28% in the chronic phase, and its secondary complications such as contracture, abnormal postures and/or movement patterns, spasticity-associated pain, also increases with time after stroke when physical and medical management of PS-SMD had been delayed in the early stroke phase. It has been published by several controlled studies that the...
Source: Toxicon - May 5, 2023 Category: Toxicology Authors: J örg Wissel Songjin Ri Anatol Kivi Source Type: research

Cerebral venous sinus thrombosis following Russell's viper (Daboia russelii) envenomation: A case report and review of the literature
We report a previously healthy middle-aged Indian female who developed cerebral venous sinus thrombosis preceded by features of disseminated bleeding diathesis following Russell's viper bite. The cerebral venous sinus thrombosis was diagnosed by magnetic resonance imaging. The patient responded well to treatment with antivenom and subcutaneous enoxaparin and had no demonstrable neurological deficits at three months of follow-up.PMID:36041514 | DOI:10.1016/j.toxicon.2022.08.014
Source: Toxicon - August 30, 2022 Category: Toxicology Authors: Ritwik Ghosh Mois és León-Ruiz Dipayan Roy Dinobandhu Naga Sona Singh Sardar Juli án Benito-León Source Type: research

Taxon-selective venom variation in adult and neonate Daboia russelii (Russell's Viper), and antivenom efficacy
Toxicon. 2021 Nov 6:S0041-0101(21)00305-6. doi: 10.1016/j.toxicon.2021.11.004. Online ahead of print.ABSTRACTMajor variations in venom composition can occur between juvenile and adult venomous snakes. However, due to logistical constraints, antivenoms are produced using adult venoms in immunising mixtures, possibly resulting in limited neutralisation of juvenile snake venoms. Daboia russelii is one of the leading causes of snakebite death across South Asia. Its venom is potently procoagulant, causing stroke in prey animals but causing in humans consumptive coagulopathy-a net anticoagulant state-and sometimes death resultin...
Source: Toxicon - November 9, 2021 Category: Toxicology Authors: Christina N Zdenek Abhinandan Chowdhury Grace Y H Haw Aude Violette Rudy Fourmy Thomas Christ Freek J Vonk Bryan G Fry Source Type: research

The effectiveness of botulinum toxin on spasticity and gait of hemiplegic patients after stroke: a systematic review and meta-analysis
This study included: randomized controlled trials (RCTs), non-randomized or controlled clinical trials (CCTs) or cluster trials, clinical trials of various phases (I-III), interrupted time series (ITS) studies with at least three data points before and after the intervention, controlled before and after (CBA) studies, prospective and retrospective comparative cohort studies, case-control and multicentred studies. The patients included in these studies had similar characteristics: age over 18 years, history of stroke and following hemiplegia, minimum modified Ashworth scale (MAS) score of 2 and duration since stroke over 6 ...
Source: Toxicon - October 9, 2021 Category: Toxicology Authors: Dimitrios Varvarousis Christina Martzivanou Dimitris Dimopoulos Georgios Dimakopoulos George I Vasileiadis Avraam Ploumis Source Type: research

The effectiveness of botulinum toxin on spasticity and gait of hemiplegic patients after stroke: A systematic review and meta-analysis
This study included: randomized controlled trials (RCTs), non-randomized or controlled clinical trials (CCTs) or cluster trials, clinical trials of various phases (I-III), interrupted time series (ITS) studies with at least three data points before and after the intervention, controlled before and after (CBA) studies, prospective and retrospective comparative cohort studies, case-control and multicentred studies. The patients included in these studies had similar characteristics: age over 18 years, history of stroke and following hemiplegia, minimum modified Ashworth scale (MAS) score of 2 and duration since stroke over 6 ...
Source: Toxicon - October 9, 2021 Category: Toxicology Authors: Dimitrios N Varvarousis Christina Martzivanou Dimitris Dimopoulos Georgios Dimakopoulos George I Vasileiadis Avraam Ploumis Source Type: research

The effectiveness of botulinum toxin on spasticity and gait of hemiplegic patients after stroke: a systematic review and meta-analysis
This study included: randomized controlled trials (RCTs), non-randomized or controlled clinical trials (CCTs) or cluster trials, clinical trials of various phases (I-III), interrupted time series (ITS) studies with at least three data points before and after the intervention, controlled before and after (CBA) studies, prospective and retrospective comparative cohort studies, case-control and multicentred studies. The patients included in these studies had similar characteristics: age over 18 years, history of stroke and following hemiplegia, minimum modified Ashworth scale (MAS) score of 2 and duration since stroke over 6 ...
Source: Toxicon - October 9, 2021 Category: Toxicology Authors: Dimitrios Varvarousis Christina Martzivanou Dimitris Dimopoulos Georgios Dimakopoulos George I Vasileiadis Avraam Ploumis Source Type: research

The effectiveness of botulinum toxin on spasticity and gait of hemiplegic patients after stroke: A systematic review and meta-analysis
This study included: randomized controlled trials (RCTs), non-randomized or controlled clinical trials (CCTs) or cluster trials, clinical trials of various phases (I-III), interrupted time series (ITS) studies with at least three data points before and after the intervention, controlled before and after (CBA) studies, prospective and retrospective comparative cohort studies, case-control and multicentred studies. The patients included in these studies had similar characteristics: age over 18 years, history of stroke and following hemiplegia, minimum modified Ashworth scale (MAS) score of 2 and duration since stroke over 6 ...
Source: Toxicon - October 9, 2021 Category: Toxicology Authors: Dimitrios N Varvarousis Christina Martzivanou Dimitris Dimopoulos Georgios Dimakopoulos George I Vasileiadis Avraam Ploumis Source Type: research

Do gait parameters improve after botulinum toxin injections in post stroke patients? A prospective study
In conclusion the use of botulinum toxin injections is beneficial in post stroke patients as this is depicted in gait parameters change which accompanies the spasticity reduction.PMID:34384786 | DOI:10.1016/j.toxicon.2021.08.001
Source: Toxicon - August 13, 2021 Category: Toxicology Authors: Dimitrios N Varvarousis Dimitris Dimopoulos George I Vasileiadis Ioannis Manolis Avraam Ploumis Source Type: research

To bee or not to bee: The potential efficacy and safety of bee venom acupuncture in humans.
Abstract Bee venom acupuncture is a form of acupuncture in which bee venom is applied to the tips of acupuncture needles, stingers are extracted from bees, or bees are held with an instrument exposing the stinger, and applied to acupoints on the skin. Bee venom is a complex substance consisting of multiple anti-inflammatory compounds such as melittin, adolapin, apamin. Other substances such as phospholipase A2 can be anti-inflammatory in low concentrations and pro-inflammatory in others. However, bee venom also contains proinflammatory substances, melittin, mast cell degranulation peptide 401, and histamine. Never...
Source: Toxicon - September 27, 2018 Category: Toxicology Authors: Cherniack EP, Govorushko S Tags: Toxicon Source Type: research

Functional outcomes following ultrasound-guided botulinum toxin type A injections to reduce spastic equinovarus in adult post-stroke patients.
CONCLUSION: Spastic equinovarus deformity observed in patients after stroke creates significant limitations in the patient's functional walking speed and distance. As a result, when BoNT-A injections accompanied by ultrasound to improve equinovarus deformity considering the innervation zones of the muscles with a specific approach are administered directly into the muscle at the correct point, we can say it provides hopeful results from a functional point of view. PMID: 29530514 [PubMed - as supplied by publisher]
Source: Toxicon - March 9, 2018 Category: Toxicology Authors: Aktürk S, Büyükavcı R, Ersoy Y Tags: Toxicon Source Type: research