• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Differential coagulotoxicity of metalloprotease isoforms from Bothrops neuwiedi snake venom and consequent variations in antivenom efficacy.
This study broadens the current understanding about the adaptive role of the SVMPs, as well as highlights how the functional diversity of SVMP isoforms can influence clinical outcomes. Key Contribution: Our findings shed light upon the hemorrhagic and coagulotoxic effects of three SVMPs of the P-III class, as well as the coagulotoxic effects of SVMPs on human, avian and amphibian plasmas. Antivenom neutralised prothrombin-activating isoforms better than Factor X activating isoforms. PMID: 32841740 [PubMed - as supplied by publisher]
Source: Toxicology Letters - August 21, 2020 Category: Toxicology Authors: Sousa LF, Bernardoni JL, Zdenek CN, Dobson J, Coimbra F, Gillett A, Lopes-Ferreira M, Moura-da-Silva AM, Fry BG Tags: Toxicol Lett Source Type: research

Involvement of ADAM10 in acrolein-induced astrocytic inflammation.
In conclusion, we demonstrate that acrolein induces astrocytic inflammation through NLRP3 inflammasome, which is regulated by ADAM10 and attributed to p38 MAPK-activated NF-κB p65 activity. PMID: 31639409 [PubMed - as supplied by publisher]
Source: Toxicology Letters - October 18, 2019 Category: Toxicology Authors: Park JH, Ji YC, Jo C, Koh YH Tags: Toxicol Lett Source Type: research

Methylenecyclopropyl glycine, not pesticide exposure as the primary etiological factor underlying Hypoglycemic Encephalopathy in Muzaffarpur, India.
Abstract Some districts of Bihar, especially Muzzaffarpur district, have been known to be affected by annual outbreak, called locally as Acute Encephalitis Syndrome (AES) which became one of the major health concerns in Bihar, due to its high fatality and complications. Several hypotheses like bat virus, heat stroke, pesticide exposure and the presence of a compound - methylenecyclopropyl glycine (MCPG) in Litchi have been proposed by different investigators for AES. When the investigators examined the symptoms, signs and the epidemiological data, bat virus and heat stroke hypothesis were ruled out. Two major hypo...
Source: Toxicology Letters - October 30, 2018 Category: Toxicology Authors: Asthana S, Dixit S, Srivastava A, Kumar A, Singh SP, Tripathi A, Das M Tags: Toxicol Lett Source Type: research

DIESEL EXHAUST PARTICLES (DEP) PRE-EXPOSURE CONTRIBUTES TO THE ANTI-OXIDANT RESPONSE IMPAIRMENT IN hCMEC/D3 DURING POST-OXYGEN AND GLUCOSE DEPRIVATION DAMAGE.
Abstract Recently, air pollution has been identified as a significant modifiable risk factor to the increasing stroke burden. Diesel exhaust particles, characterized by high polycyclic aromatic hydrocarbons content, constitute an important component of outdoor air pollution and is known to cause oxidative stress, and could therefore contribute to and exacerbate the effects of ROS in post-ischemic injury. hCMEC/D3 cells have been submitted to 48h treatment with diesel exhaust particles (25μg/ml and 50μg/ml, DEP50) or alternatively to 3h of oxygen and glucose deprivation, followed by 1h of oxygen and glucose resto...
Source: Toxicology Letters - April 8, 2017 Category: Toxicology Authors: Farina F, Lonati E, Brambilla A, Magro RD, Milani C, Botto L, Sancini G, Palestini P, Bulbarelli A Tags: Toxicol Lett Source Type: research

17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha.
Abstract Oxidative stress-induced DNA damage results in over-activation of poly(ADP-ribose) polymerase 1 (PARP1), leading to parthanatos, a newly discovered cell elimination pathway. Inhibition of PARP1-dependent cell death has shown to improve the outcome of diseases, including stroke, heart ischemia, and neurodegenerative diseases. In the present study we aimed to detect whether estrogen plays a protective role in inhibiting parthanatos. We utilized human mammary adenocarcinoma cells (MCF7) that abundantly express the estrogen receptor alpha and beta (ERα and ERβ). Parthanatos was induced by challenging the ce...
Source: Toxicology Letters - September 30, 2014 Category: Toxicology Authors: Batnasan E, Wang R, Wen J, Ke Y, Li X, Bohio AA, Zeng X, Huo H, Han L, Boldogh I, Ba X Tags: Toxicol Lett Source Type: research