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Coronary artery calcium score as a predictor for incident stroke: Systematic review and meta-analysis
The objective of this study was to investigate the predictive value of CACS obtained by non-contrast electrocardiogram-gated computed tomography for incident stroke.
Source: International Journal of Cardiology - February 7, 2017 Category: Cardiology Authors: Kongkiat Chaikriangkrai, Hye Yeon Jhun, Ghanshyam Palamaner Subash Shantha, Aref Bin Abdulhak, Gardar Sigurdsson, Faisal Nabi, John J. Mahmarian, Su Min Chang Source Type: research

Epigallocatechin-3-gallate modulates arrhythmogenic activity and calcium homeostasis of left atrium
Atrial fibrillation (AF) is the commonest sustained arrhythmia, and increases the risk of stroke, heart failure, and mortality. Calcium (Ca2+) overload and oxidative stress are thought to participate in the pathogenesis of AF. Epigallocatechin-3-gallate (EGCG) has an antioxidative effect and been shown to be beneficial in promoting cardiovascular health. However, it is not clear if EGCG directly modulates the electrophysiological characteristics and Ca2+ homeostasis of the left atrium (LA).
Source: International Journal of Cardiology - January 13, 2017 Category: Cardiology Authors: Jun-Hei Chang, Shih-Lin Chang, Po-Da Hong, Ping-Nan Chen, Chih-Hsueng Hsu, Yen-Yu Lu, Yao-Chang Chen Source Type: research

Massive Left Ventricular Calcification
94-year-old male presented for follow-up for shortness of breath. He has a history of two episodes of anterior and inferior myocardial infarction (MI) (eight and thirteen years ago) with stent revascularization, ischemic cardiomyopathy, implantable cardioverter defibrillator, paroxysmal atrial fibrillation, hypertension, hyperlipidemia, diabetes, and stroke. Lab investigation showed normal kidney function and calcium level. Echocardiography showed a reduced left ventricular (LV) ejection fraction of 25%, diastolic dysfunction, severe anteroseptal hypokinesis, otherwise normal LV.
Source: International Journal of Cardiology - April 28, 2015 Category: Cardiology Authors: Anas Alani Tags: Letter to the Editor Source Type: research

Vitamin D deficiency and atrial fibrillation
Vitamin D deficiency has been linked with hypertension, coronary artery disease, and stroke, but there is no consensus regarding the possible association between vitamin D deficiency and atrial fibrillation (AF). Vitamin D negatively regulates the renin–angiotensin–aldosterone-system (RAAS), mediates calcium homeostasis, binds to vitamin D receptors on cardiac myocytes, and has antioxidant properties that may reduce levels of reactive oxygen species (ROS) in the atria, which contribute to inflammation and proarrhythmic substrate formation.
Source: International Journal of Cardiology - February 10, 2015 Category: Cardiology Authors: Joseph Thompson, Rynda Nitiahpapand, Prashan Bhatti, Antonios Kourliouros Tags: Review Source Type: research

Association of computed tomography-derived left atrial size with major cardiovascular events in the general population: The Heinz Nixdorf Recall Study
Conclusion: LA size is associated with incident major CV events independent of risk factors and CAC-score. Once cardiac CT imaging is performed, assessment of LA size may complement information of this imaging modality.Highlights:
Source: International Journal of Cardiology - April 28, 2014 Category: Cardiology Authors: Amir A. Mahabadi, Marie H. Geisel, Nils Lehmann, Christian Lammerding, Hagen Kälsch, Marcus Bauer, Susanne Moebus, Karl-Heinz Jöckel, Raimund Erbel, Stefan Möhlenkamp Tags: Original Articles Source Type: research

Use of drug treatment for secondary prevention of cardiovascular disease in urban and rural communities of China: China Kadoorie Biobank Study of 0.5million people
Conclusions: Despite recent improvements in hospital care in China, only one in three individuals with prior CVD was routinely treated with any proven secondary preventive drugs. The treatment rates were correlated with the existence of other risk factors, in particular evidence of hypertension.
Source: International Journal of Cardiology - January 23, 2014 Category: Cardiology Authors: Yiping Chen, Liming Li, Qiuli Zhang, Robert Clarke, Junshi Chen, Yu Guo, Zheng Bian, Xianhai Pan, Richard Peto, Ran Tao, Kunxiang Shi, Rory Collins, Liangcai Ma, Huarong Sun, Zhengming Chen, on behalf of China Kadoorie Biobank Study Tags: Original Articles Source Type: research

Heme iron intake and acute myocardial infarction: A prospective study of men
Conclusions: Findings from this prospective study indicate that a high heme iron intake, particularly with simultaneous low intake of minerals that can decrease iron absorption, may increase the risk of fatal AMI.
Source: International Journal of Cardiology - January 22, 2014 Category: Cardiology Authors: Joanna Kaluza, Susanna C. Larsson, Niclas Håkansson, Alicja Wolk Tags: Original Articles Source Type: research

Recurrent stroke and myocardial infarction in a young woman with severe osteoporosis and hyperparathyroidism
We have taken great interest in the recently published article entitled “ Effect of calcium or vitamin D supplementation on vascular outcomes: A meta-analysis of randomized controlled trial” . Likewise, since parathormone (PTH) is a vasoactive peptide, we, herein, wish to draw attention to the fact that primary hyperparathyroidism (pHPT) can –as well– be in association with increased risk of cardiovascular diseases (i.e. myocardial infarction (MI), heart failure, thrombosis or cardioembolism, hypertension), stroke and osteoporosis . In this regard, we exemplify the clinical scenario of one of our pertinent patients.
Source: International Journal of Cardiology - January 21, 2014 Category: Cardiology Authors: Murat Kara, Levent Özçakar, Hatice Gözde Sümer, Timur Ekiz, Sibel Özbudak Demir, Ayşen Akıncı Tags: Online Letters to the Editor Source Type: research

Digoxin use is associated with increased risk of stroke in patients with non-valvular atrial fibrillation — a nationwide population-based cohort study
Atrial fibrillation (AF) is associated with increased risk of morbidity and mortality. Digoxin is often used as a rate control agent in AF patients, particularly in those with systolic heart failure. Although digoxin use in AF patients can reduce heart failure symptoms, increase exercise capacity and decrease hospitalizations , unfavorable effects on long-term outcomes have been reported . In the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study, a post-hoc analysis showed a higher rate of mortality in patients treated with digitalis medication . A study of the “Registry of Information and K...
Source: International Journal of Cardiology - September 23, 2013 Category: Cardiology Authors: Shih-Sheng Chang, Kuan-Cheng Chang, Yu-Chen Wang, Chih-Hsin Muo, Pei-Ying Pai, Chi-Bin Chang, Chi-Yuan Li, Fung-Chang Sung Tags: Online Letters to the Editor Source Type: research

Effect of calcium or vitamin D supplementation on vascular outcomes: A meta-analysis of randomized controlled trials
Conclusions: Calcium supplementation might increase the risk of major cardiovascular events, myocardial infarction, and stroke compared to the risk with a placebo.
Source: International Journal of Cardiology - September 12, 2013 Category: Cardiology Authors: Pei-Juan Mao, Chi Zhang, Lan Tang, Yu-Qiong Xian, Yan-Song Li, Wei-Dong Wang, Xiu-Hua Zhu, Hua-Li Qiu, Jia He, Yu-Hao Zhou Tags: Reviews Source Type: research

Ivabradine is BEAUTIFUL in concurrent acute coronary syndrome and stroke
We report the safe use of oral ivabradine in 2 patients with concurrent ACS and stroke, achieving heart rate reduction and angina relief without affecting blood pressure.
Source: International Journal of Cardiology - September 20, 2012 Category: Cardiology Authors: Pow-Li Chia, David Foo Tags: Online letters to the Editor Source Type: research

Aortic valve calcium score as a predictor for outcome after TAVI using the CoreValve revalving system
Abstract: Background: TAVI is a novel treatment option for patients at too high risk for surgery. Risk scores for surgical valve replacement failed to accurately predict outcomes after TAVI and alternative risk parameters are lacking so far.Objective: We evaluated the CT-derived aortic valve calcification score as a predictor for outcome during and after TAVI.Methods: Transfemoral TAVI using the CoreValve device was performed in 68 patients, in whom the aortic valve calcium score was determined from preprocedural 64-sclice ECG gated CT-scans.Results: 30-day MACE rate (death, stroke, MI) was 10.3%, 1-year mortality was 11.8...
Source: International Journal of Cardiology - December 26, 2011 Category: Cardiology Authors: Alexander W. Leber, Markus Kasel, Thomas Ischinger, Ulrich H. Ebersberger, Diethmar Antoni, Martin Schmidt, Gotthard Riess, Vivian Renz, Armin Huber, Thomas Helmberger, Ellen Hoffmann Tags: Original Articles Source Type: research