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Po-04-216 patient enabled inr optimization : a multicenter prospective study
For patients using Vitamin K antagonists (VKA), maximizing time within the therapeutic range (TTR) reduces stroke, major hemorrhage, and death. Despite improvements in counselling and patient education, patients using Vitamin K antagonists have a poor TTR.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Muthiah Subramanian, Walli Mohammed, Hetan Shah, Sachin D. Yalagudri, Daljeet K. Saggu, Calambur Narasimhan Source Type: research

Po-670-04 long-term outcomes associated with the highest-risk procedural indications for watchman implantation
There is a scarcity of studies reporting long-term outcomes associated with the range of procedural indications for Watchman implantation in real-world practice, particularly the highest-risk indications of CHA2DS2-VASc ≥5 (very high stroke risk) and intracranial hemorrhage (ICH).
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Usama Daimee, Thomas Boyle, Erica Sheree Hart, Ronald D. Berger Source Type: research

Po-713-05 ischemic stroke after prophylaxis with left atrial appendage closure vs non-warfarin oral anticoagulants: a “real-world” multicenter comparison of stroke severity
In randomized trials, strokes occurring in patients who have received left atrial appendage closure (LAAC) devices have been less severe than in patients receiving warfarin prophylaxis - an observation thought related to warfarin ’s higher rate of hemorrhagic stroke (which are known to have worse outcomes). Similar stroke rates have been described with LAAC vs NOACs (non-warfarin oral anticoagulants), but the low hemorrhagic stroke rate of NOACs raises the question of stroke severity between these two therapies.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Mohit K. Turagam, Iwanari Kawamura, Domenico G. Della Rocca, Pavel Hala, Thomas Flautt, Deji Adedokun, Moritoshi Funasako, Daniel Ross Musikantow, Srinivas R. Dukkipati, David H. Yoo, Petr Neuzil, Devi G. Nair, Douglas N. Gibson, Miguel Valderrabano, Andr Source Type: research

B-po03-152 left atrial appendage occlusion in patients with intracranial hemorrhage
Patients with prior intracranial hemorrhage (ICH) and atrial fibrillation (AF) are at increased risk of recurrent bleeding; and often not treated with oral anticoagulation despite high risk of ischemic stroke.
Source: Heart Rhythm - July 28, 2021 Category: Cardiology Authors: Jalaj Garg, Siddharth Shah, Kuldeep Bharat Shah, Mohit K. Turagam, Andrea Natale, Dhanunjaya R. Lakkireddy Source Type: research

B-po03-151 left atrial appendage occlusion as alternative approach for stroke prevention in hereditary hemorrhagic telangiectasia patients with atrial fibrillation
In this study, we evaluate the safety and efficacy of left atrial appendage occlusion (LAAO) for stroke prevention in HHT.
Source: Heart Rhythm - July 28, 2021 Category: Cardiology Authors: Mohammed Alghammass, Jad Aldanaf, Elizabeth Dranow, Kevin Whitehead Source Type: research

EP News: Quality Improvement and Outcomes: Defining and Measuring Atrial Fibrillation Quality Indicators in Canada
In 2016, the Working Group published an initial report identifying and defining priority QIs in 3 distinct categories: access to care, treatment, and outcomes (Can J Cardiol 2016;32:1566, PMID 27297003). An iterative process resulted in the selection of 3 priority QIs: (i) proportion of AF patients at high risk of stroke receiving an oral anticoagulant, (ii) annual rate of stroke, (iii) annual rate of major hemorrhage. A feasibility assessment followed, which determined that none of the QIs as defined could be adequately measured with existing data sources.
Source: Heart Rhythm - April 26, 2021 Category: Cardiology Authors: Roopinder K. Sandhu, Stephen B. Wilton, Anne Marie Smith, Paul Dorian Source Type: research

Left Atrial Appendage Closure Device Implantation in Patients with Atrial Fibrillation and Prior Intracranial Hemorrhage “No Man Left Behind”
Several LAA closure devices have been developed for patients with atrial fibrillation (AF) seeking an alternative to long-term oral anticoagulation (OAC). The PROTECT AF trial was the first multicenter randomized controlled trial (RCT) comparing LAA closure device vs. OAC with Warfarin. Primary safety events were statistically more frequent in the device group (7.4% vs. 4.4%). At a mean follow up of 3.8 years LAA closure device showed superiority for the primary efficacy endpoint (i.e., composite of stroke, cardiovascular death and systemic embolism), with a 34% relative risk reduction in total mortality1-3 However, with t...
Source: Heart Rhythm - January 14, 2019 Category: Cardiology Authors: Luigi Di Biase, Jorge Romero Source Type: research

Left Atrial Appendage Closure Device Implantation in Patients with Prior Intracranial Hemorrhage
The Watchman ™ device (Boston Scientific, MN), used for left atrial appendage closure (LAAC) was approved for stroke prevention in patients with atrial fibrillation (AF) and an appropriate rationale to avoid long-term oral anticoagulation. Patients with AF and prior intracranial hemorrhage (ICH) were excluded from clinical trials due to perceived risks of peri-operative anticoagulation.
Source: Heart Rhythm - December 2, 2018 Category: Cardiology Authors: Erika Hutt, Oussama M. Wazni, Walid I. Saliba, Mohamed Kanj, Khaldoun G. Tarakji, Jose Aguilera, Amr F. Barakat, Peter Rasmussen, Ken Uchino, Andrew Russman, Shazam Hussain, Dolora Wisco, Samir Kapadia, Bruce D. Lindsay, Ayman A. Hussein Source Type: research

In Memoriam—Rashid A. Massumi, MD 1926–2015
Professor Rashid A. Massumi passed away after suffering a hemorrhagic stroke on May 29, 2015, in Los Angeles, California. He was surrounded by his family and friends. Rashid Massumi was a remarkable man and one of the early pioneers of clinical cardiology and rhythmology.
Source: Heart Rhythm - September 21, 2015 Category: Cardiology Authors: Mohammad Shenasa, Melvin Scheinman Source Type: research

Risk of Stroke and Intracranial Hemorrhage in 9,727 Chinese with Atrial Fibrillation in Hong Kong
Source: Heart Rhythm - April 15, 2014 Category: Cardiology Authors: Chung-Wah Siu, Gregory Y H Lip, PhD. Kwok-Fai Lam, Hung-Fat Tse Source Type: research

Risk of stroke and intracranial hemorrhage in 9727 Chinese with atrial fibrillation in Hong Kong
Source: Heart Rhythm - April 15, 2014 Category: Cardiology Authors: Chung-Wah Siu, Gregory Y.H. Lip, Kwok-Fai Lam, Hung-Fat Tse Source Type: research