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Source: Behavioural Brain Research
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Total 143 results found since Jan 2013.
A randomized controlled trial of Changes in resting-state functional connectivity associated with short-term motor learning of chopstick use with the non-dominant hand
CONCLUSION]: Offline enhancement of RSFC in these networks was shown to contribute to early chopstick-use motor learning with the left hand. These results serve as a basis for future studies on compensatory networks in individuals with stroke.PMID:37506851 | DOI:10.1016/j.bbr.2023.114599
Source: Behavioural Brain Research - July 28, 2023 Category: Neurology Authors: Sayori Takeda Reiko Miyamoto Source Type: research
Long-term behavioural alterations in mice following transient cerebral ischemia
The objective of this study was to clarify whether and to what extent mouse behaviour was altered during a 6 months period after cerebral stroke. Experimental stroke was induced in mice by intraluminal filament insertion into the middle cerebral artery (fMCAo). Neurological deficits, recovery rate, motor performance, and circadian activity were evaluated following ischemia. We observed severe neurological deficits, motor impairments, and delay in the recovery rate of mice during the first 14 days after fMCAo. Aberrant circadian activity and distorted space map were seen in fMCAo mice starting one month after ischemia, simi...
Source: Behavioural Brain Research - July 22, 2023 Category: Neurology Authors: Zane Dzirkale Vladimirs Pilipenko Barbara Pijet Linda Klimaviciusa Jolanta Upite Karolina Protokowicz Leszek Kaczmarek Baiba Jansone Source Type: research
NLRP3 inflammasome activation after ischemic stroke
Behav Brain Res. 2023 Jul 11;452:114578. doi: 10.1016/j.bbr.2023.114578. Online ahead of print.ABSTRACTCerebral ischemia is a pathological condition resulting from the cessation or reduction of blood supply to the cerebral arteries. Neurological deficits that are clinically relevant can arise as a result of brain damage. The etiology of stroke is multifaceted and intricate, with the inflammatory response being a crucial component that warrants significant attention. Following a cerebrovascular accident, the levels of interleukin-1 beta and interleukin-18 within the central nervous system escalate due to the activation of t...
Source: Behavioural Brain Research - July 12, 2023 Category: Neurology Authors: Ping-Ping Han Yu Han Xin-Ya Shen Zhen-Kun Gao Xia Bi Source Type: research
DUSP10 alleviates ischemic stroke-induced neuronal damage by restricting p38/JNK pathway
This study aimed to investigate the effect of on apoptosis in primary cortical neurons exposed to oxygen-glucose deprivation and reoxygenation (OGD/R) and mice suffered from transient middle cerebral artery occlusion and reperfusion (MCAO/R). The results showed that DUSP10 overexpression improved survival and reduced apoptosis in neurons subjected to OGD/R, which was manifested by decreased apoptotic proteins (cleaved caspase 3 and bax) and TUNEL+ cells, as well as increased the anti-apoptotic protein (bcl-2). DUSP10 overexpression inhibited the p38/JNK signaling pathway after OGD/R treatment, whilst DUSP10 knockdown had o...
Source: Behavioural Brain Research - May 10, 2023 Category: Neurology Authors: Ni-Na Song Ying Zhao Chuang Sun Jun Zhang Guang-Jun Lin Xiao-Wei Yin Chun-Ye Ma Source Type: research
Rat BM-MSCs secretome alone and in combination with stiripentol and ISRIB, ameliorated microglial activation and apoptosis in experimental stroke
CONCLUSION: STP and trans ISRIB, alone and in combination with rat BM-MSCs secretome, might be considered as potential neuroprotective agents in the acute ischemic stroke (AIS) management.DATA AVAILABILITY STATEMENT: Data will be made available on reasonable request.PMID:37146724 | DOI:10.1016/j.bbr.2023.114471
Source: Behavioural Brain Research - May 5, 2023 Category: Neurology Authors: Neha Dhir Ashish Jain Amit Raj Sharma Sunil Sharma Dhruv Mahendru Ajay Patial Deepti Malik Ajay Prakash Savita Verma Attri Shalmoli Bhattacharyya Bishan Das Radotra Bikash Medhi Source Type: research
Impairments and Compensation in String-pulling After Middle Cerebral Artery Occlusion in the Rat
This study describes middle cerebral artery occlusion (MCAO) dependent changes in the bilaterally dependent hand use behavior of string-pulling in the rat. The task involves making hand-over-hand movements to pull down a string that contains a food reward attached to its end. MCAO rats missed the string more often with both hands than Sham rats. When the string was missed on the contralateral to MCAO body side, rats continued to cycle through subcomponents of string-pulling behavior as if the string were grasped in the hand. Rats also failed to make a grasping motion with the contralateral to MCAO hand when the string was ...
Source: Behavioural Brain Research - May 5, 2023 Category: Neurology Authors: Muriel Hart Ashley A Blackwell Ian Q Whishaw Douglas G Wallace Joseph L Cheatwood Source Type: research
Ramelteon improves blood-brain barrier of focal cerebral ischemia rats to prevent post-stroke depression via upregulating occludin
This study explored the effects of ramelteon with prophylactic administration on blood-brain barrier in rats with middle cerebral artery occlusion (MCAO) and the oxygen-glucose deprivation/reperfusion (OGD/R) bEnd.3 cells and found that ramelteon pretreatment improved the depressive-like behaviors and decreased infarct area in MCAO rats. Also, this study found ramelteon pretreatment improved viability and inhibited permeability in OGD/R cells. In addition, this study found that MCP-1, TNF-α, and IL-1 levels were raised in the MCAO rats and that occludin protein and mRNA levels were decreased in the MCAO and the OGD/R mode...
Source: Behavioural Brain Research - May 5, 2023 Category: Neurology Authors: Xuchen Qi Ziqi Tang Xian Shao Zhaowei Wang Mengyun Li Xiaobing Zhang Lingyan He Jianli Wang Xuebin Yu Source Type: research
Impairments and Compensation in String-pulling After Middle Cerebral Artery Occlusion in the Rat
This study describes middle cerebral artery occlusion (MCAO) dependent changes in the bilaterally dependent hand use behavior of string-pulling in the rat. The task involves making hand-over-hand movements to pull down a string that contains a food reward attached to its end. MCAO rats missed the string more often with both hands than Sham rats. When the string was missed on the contralateral to MCAO body side, rats continued to cycle through subcomponents of string-pulling behavior as if the string were grasped in the hand. Rats also failed to make a grasping motion with the contralateral to MCAO hand when the string was ...
Source: Behavioural Brain Research - May 5, 2023 Category: Neurology Authors: Muriel Hart Ashley A Blackwell Ian Q Whishaw Douglas G Wallace Joseph L Cheatwood Source Type: research
Rat BM-MSCs secretome alone and in combination with stiripentol and ISRIB, ameliorated microglial activation and apoptosis in experimental stroke
CONCLUSION: STP and trans ISRIB, alone and in combination with rat BM-MSCs secretome, might be considered as potential neuroprotective agents in the acute ischemic stroke (AIS) management.DATA AVAILABILITY STATEMENT: Data will be made available on reasonable request.PMID:37146724 | DOI:10.1016/j.bbr.2023.114471
Source: Behavioural Brain Research - May 5, 2023 Category: Neurology Authors: Neha Dhir Ashish Jain Amit Raj Sharma Sunil Sharma Dhruv Mahendru Ajay Patial Deepti Malik Ajay Prakash Savita Verma Attri Shalmoli Bhattacharyya Bishan Das Radotra Bikash Medhi Source Type: research
Ramelteon improves blood-brain barrier of focal cerebral ischemia rats to prevent post-stroke depression via upregulating occludin
This study explored the effects of ramelteon with prophylactic administration on blood-brain barrier in rats with middle cerebral artery occlusion (MCAO) and the oxygen-glucose deprivation/reperfusion (OGD/R) bEnd.3 cells and found that ramelteon pretreatment improved the depressive-like behaviors and decreased infarct area in MCAO rats. Also, this study found ramelteon pretreatment improved viability and inhibited permeability in OGD/R cells. In addition, this study found that MCP-1, TNF-α, and IL-1 levels were raised in the MCAO rats and that occludin protein and mRNA levels were decreased in the MCAO and the OGD/R mode...
Source: Behavioural Brain Research - May 5, 2023 Category: Neurology Authors: Xuchen Qi Ziqi Tang Xian Shao Zhaowei Wang Mengyun Li Xiaobing Zhang Lingyan He Jianli Wang Xuebin Yu Source Type: research
Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: expression changes of NMDA receptor subunits and NT-3
This study was designed to discover the effect of MSCs injection in the nucleus accumbens (NAc) on the reinstatement of behavior in morphine-induced conditioned place preference (CPP) in male rats. The CPP was induced via intra-peritoneal (i.p.) morphine injection (5mg/kg) for three consecutive days. After being tested for CPP induction, animals received MSCs or culture medium (DMEM F-12) in their NAc using stereotaxic surgery. Following extinction, a priming dose of morphine (2mg/kg) was administered to induce reinstatement. Expression of GluN1, GluN2A, and GluN2B subunits of the NMDA receptor and the NT-3 gene in the NAc...
Source: Behavioural Brain Research - February 28, 2023 Category: Neurology Authors: Parviz Dousti Kataj Nasim Vousooghi Mahmoud Reza Hadjighassem Maryam Farahmandfar Somayeh Ebrahimi-Barough Source Type: research
Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: Expression changes of NMDA receptor subunits and NT-3
This study was designed to discover the effect of MSCs injection in the nucleus accumbens (NAc) on the reinstatement of behavior in morphine-induced conditioned place preference (CPP) in male rats. The CPP was induced via intra-peritoneal (i.p.) morphine injection (5 mg/kg) for three consecutive days. After being tested for CPP induction, animals received MSCs or culture medium (DMEM F-12) in their NAc using stereotaxic surgery. Following extinction, a priming dose of morphine (2 mg/kg) was administered to induce reinstatement. Expression of GluN1, GluN2A, and GluN2B subunits of the NMDA receptor and the NT-3 gene in the N...
Source: Behavioural Brain Research - February 28, 2023 Category: Neurology Authors: Parviz Dousti Kataj Nasim Vousooghi Mahmoudreza Hadjighassem Maryam Farahmandfar Somayeh Ebrahimi-Barough Source Type: research
