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Storax Protected Primary Cortical Neurons from Oxygen-Glucose Deprivation/Reoxygenation Injury via Inhibiting the TLR4/TRAF6/NF- κB Signaling Pathway
This study aimed to elucidate the neuroprotective effects and underlying mechanisms of storax on oxygen-glucose deprivation/reoxygenation (OGD/R) in injured cortical neurons. The cortical neurons of Wistar rats were primarily cultured in vitro. TheTUNELmethod and CM-H2DCFDA probe were used to detect cell apoptosis and reactive oxygen species (ROS) expression. Enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, and Western blot were used to detect the expression of inflammatory cytokines and proteins of the TLR4/TRAF6/NF-κB signaling pathway. Immunofluorescence was used to measure NF-κB nuc...
Source: Brain Research - July 25, 2022 Category: Neurology Authors: Lin Li Shaoqian Yue Rui Han Yajun Yu Peng Zhang Ling Lv Jinqiang Zhu Min Zhou Xiang Fan Han Zhang Source Type: research

Xueshuantong injection combined with Salvianolate lyophilized injection improves the synaptic plasticity against focal cerebral ischemia/ reperfusion injury in rats through PI3K/ AKT/ mTOR and RhoA/ROCK pathways
In this study, we investigated the neuroprotective effects of XST combined with SLI in the recovery stage of middle cerebral artery occlusion / reperfusion (MCAO/R) injury rat. Wistar rats were subjects to MCAO/R, then were treated with SLI or XST alone, or with their combination (1X1S) via tail injection daily for 14 days. The pathological status of the brain was detected by neurological deficit scores, TTC, regional cerebral blood flow and Nissl staining. Golgi-Cox staining was used to assess dendritic, axonal and synaptic remodeling. The expression of MAP-2, β-Tubulin, PSD95, SYN, BDNF and VEGF were analyzed by western...
Source: Brain Research - April 24, 2022 Category: Neurology Authors: Qing Yuan Fu-Jiang Wang Zhuang-Zhuang Jia Tong Zhang Jin Sun Xin-Yuan Du Shao-Xia Wang Li-Juan Chai Li-Min Hu Source Type: research

Patchouli Alcohol protects against Ischemia/Reperfusion-induced brain injury via inhibiting neuroinflammation in normal and obese mice.
In conclusion, we demonstrated for the first time that PA could protect against cerebral I/R injury not only in normal mice but also in obese mice via inhibiting inflammation, suggesting that PA can be a potential drug for clinical treatment of ischemic stroke. PMID: 29291393 [PubMed - as supplied by publisher]
Source: Brain Research - December 29, 2017 Category: Neurology Authors: Wei LL, Chen Y, Yu QY, Wang Y, Liu G Tags: Brain Res Source Type: research

Hyperforin protects against acute cerebral ischemic injury through inhibition of interleukin-17A-mediated microglial activation.
In conclusion, our results clearly showed that hyperforin could protect against acute cerebral ischemic injury through inhibition of interleukin-17A-mediated microglial activation and polarization of microglia to M2 phenotype. PMID: 28870826 [PubMed - as supplied by publisher]
Source: Brain Research - September 1, 2017 Category: Neurology Authors: Ma L, Pan X, Zhou F, Liu K, Wang L Tags: Brain Res Source Type: research

Hyperforin promotes post-stroke functional recovery through interleukin (IL)-17A-mediated angiogenesis.
Abstract Hyperforin, the main active ingredient of the medicinal plant Hypericum perforatum, has been shown to be neuroprotective against acute ischemic stroke. However, the long-term actions of hyperforin on the post-stroke functional recovery and underlying mechanisms have not been investigated. C57BL/6 wild-type mice or interleukin (IL)-17A knock-out mice underwent middle cerebral artery occlusion (60min) followed by reperfusion for 28 days. Here, we found that delayed treatment with hyperforin significantly promoted functional recovery and increased IL-17A expression in the ischemic hemisphere at 28 days post-...
Source: Brain Research - June 16, 2016 Category: Neurology Authors: Zhang J, Yao C, Chen J, Zhang Y, Yuan S, Lin Y Tags: Brain Res Source Type: research

Effect of lavender oil (Lavandula angustifolia) on cerebral edema and its possible mechanisms in an experimental model of stroke.
Abstract Lavender belongs to the family Labiatae and has a variety of cosmetic uses as well as therapeutic purposes in herbal medicine. The present study was conducted to evaluate the protective effect of lavender oil against brain edema and its possible mechanisms in an experimental model of stroke. Under Laser-Doppler Flowmetry, focal cerebral ischemia was induced by the transient occlusion of the middle cerebral artery for 1h in rats. Lavender oil (100, 200, and 400mg/kg ip (and/or vehicle was injected at the onset of ischemia. Infarct size, cerebral edema, functional outcome, and oxidative stress biomarkers we...
Source: Brain Research - December 30, 2013 Category: Neurology Authors: Vakili A, Sharifat S, Akhavan MM, Bandegi AR Tags: Brain Res Source Type: research