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Montelukast Sodium Protects against Focal Cerebral Ischemic Injury by Regulating Inflammatory Reaction via Promoting Microglia Polarization
CONCLUSION: Montelukast sodium can protect against focal cerebral ischemic injury by regulating inflammatory reaction via promoting microglia polarization.PMID:37499731 | DOI:10.1016/j.brainres.2023.148498
Source: Brain Research - July 27, 2023 Category: Neurology Authors: Yanling Wang Ho Jun Yun Yuchuan Ding Huishan Du Xiaokun Geng Source Type: research

Epigenetic modifications in the motor cortex caused by exercise or pharmacological inhibition of histone deacetylases (HDACs) after intracerebral hemorrhage (ICH)
This study sought to examine the effect of epigenetic treatment using a histone deacetylase (HDAC) inhibitor, sodium butyrate (NaB), and exercise on epigenetic markers in the bilateral motor cortex after intracerebral hemorrhage (ICH) to identify a more enriched neuronal condition for neurorehabilitation. Forty-one male Wistar rats were randomly divided into five groups: sham (n=8), control (n=9), NaB, exercise (n=8), and NaB and exercise (n=8). Intraperitoneal administration of an HDAC inhibitor (300 mg/kg NaB) and treadmill exercise (11 m/min for 30 min) was conducted five days a week for approximately four weeks. ICH sp...
Source: Brain Research - February 21, 2023 Category: Neurology Authors: Hiroshi Maejima Misato Okamura Takahiro Inoue Yasuyuki Takamatsu Taichi Nishio Yushan Liu Source Type: research

EPO has multiple positive effects on astrocytes in an experimental model of ischemia
Brain Res. 2022 Dec 19:148207. doi: 10.1016/j.brainres.2022.148207. Online ahead of print.ABSTRACTErythropoietin (EPO) has neuroprotective effects in central nervous system injury models. In clinical trials EPO has shown beneficial effects in traumatic brain injury (TBI) as well as in ischemic stroke. We have previously shown that EPO has short-term effects on astrocyte glutamatergic signalling in vitro and that administration of EPO after experimental TBI decreases early cytotoxic brain edema and preserves structural and functional properties of the blood-brain barrier. These effects have been attributed to preserved or r...
Source: Brain Research - December 22, 2022 Category: Neurology Authors: Jonas Blixt Yutong Song Michael Wanecek Eli Gunnarson Source Type: research

Neuroprotective effects of protein tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice.
In this study, we confirmed the ameliorative effects of KY-226 on ischemia/reperfusion (I/R) injury using a murine model of middle cerebral artery occlusion (MCAO). ICR mice were subjected to MCAO for 2 h followed by reperfusion. Although KY-226 permeability was poor through the blood-brain barrier (BBB) of normal mice, it could penetrate through the BBB of mice after I/R insult. Intraperitoneal KY-226 administration elicited dose-dependent reductions in infarcted brain areas and improved neurological deficits. The neuroprotective effects of KY-266 were obtained when administered within 0.5 h after reperfusion. KY-226 (10 ...
Source: Brain Research - April 26, 2018 Category: Neurology Authors: Sun M, Izumi H, Shinoda Y, Fukunaga K Tags: Brain Res Source Type: research