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Continuous theta burst stimulation provides neuroprotection by accelerating local cerebral blood flow and inhibiting inflammation in a mouse model of acute ischemic stroke.
Abstract Acute ischemic stroke is a leading cause of disability with limited therapeutic options. Continuous theta burst stimulation (cTBS) has recently been shown to be a promising noninvasive therapeutic strategy for neuroprotection in ischemic stroke patients. Here, we investigated the protective effects of cTBS following acute infarction using a photothrombotic stroke (PTS) model in the right posterior parietal cortex (PPC) of C57BL/6 mice. Treatment with cTBS resulted in a reduction in the volume of the infarct region and significantly increased vascular diameter and blood flow velocity in peri-infarct region...
Source: Brain Research - October 2, 2019 Category: Neurology Authors: Wu C, Li MN, Feng YW, He XF, Li WQ, Liang FY, Li X, Li G, Pei Z, Lan Y, Xu GQ Tags: Brain Res Source Type: research

Baicalin alleviates ischemia-induced memory impairment by inhibiting the phosphorylation of CaMKII in hippocampus.
This study was to reveal the mechanisms by which baicalin protected hippocampal neurons and improved learning and memory impairment after global cerebral ischemia/reperfusion in gerbil. In the present study, the Morris water maze test showed that baicalin significantly improved learning and memory impairment after global cerebral ischemia/reperfusion in gerbils. Laser scanning confocal fluorescence microscope examination showed that baicalin suppressed OGD-induced augmentation of intracellular calcium concentration. Western blotting analysis indicated that baicalin suppressed ischemia-caused elevated phosphorylation level ...
Source: Brain Research - March 21, 2016 Category: Neurology Authors: Wang P, Cao Y, Yu J, Liu R, Bai B, Qi H, Zhang Q, Guo W, Zhu H, Qu L Tags: Brain Res Source Type: research

Valproic acid ameliorates ischemic brain injury in hyperglycemic rats with permanent middle cerebral occlusion.
In this study, we investigate the effects of VPA on permanent ischemic stroke with hyperglycemia. Hyperglycemia was induced by streptozotocin (STZ) injection 3 days before. Test animals received a single injection of VPA immediately after induction of ischemia. Control animals received occlusion and physiological saline injection, or STZ, occlusion, and saline. Magnetic resonance imaging of cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) was performed 60min after ischemia. Infarct volume, neurological deficits, rotarod test performance, and immunohistological markers were assessed 3 days after ischemia. ...
Source: Brain Research - February 23, 2015 Category: Neurology Authors: Suda S, Ueda M, Nito C, Nishiyama Y, Okubo S, Abe A, Aoki J, Suzuki K, Sakamoto Y, Kimura K Tags: Brain Res Source Type: research

Anti-oxidative nutrient rich diet protects against acute ischemic brain damage in rats.
Abstract We evaluated the neuroprotective effects of an anti-oxidative nutrient rich enteral diet (AO diet) that contained rich polyphenols (catechins and proanthocyanidins) and many other anti-oxidative ingredients. Wistar rats were treated with either vehicle, normal AO diet (containing 100kcal/100ml, catechin 38.75mg/100ml and proanthocyanidin 19mg/100ml, 1ml/day), or high AO diet (containing 10 times the polyphenols of the normal AO diet) for 14 days, and were subjected to 90min of transient middle cerebral artery occlusion. The AO diet improved motor function, reduced cerebral infarction volume, and decreased...
Source: Brain Research - August 28, 2014 Category: Neurology Authors: Yunoki T, Deguchi K, Omote Y, Liu N, Liu W, Hishikawa N, Yamashita T, Abe K Tags: Brain Res Source Type: research

Neurodegeneration after transient brain ischemia in aged mice: Beneficial effects of bilobalide.
In conclusion, aged mice show some differences in their response to transient ischemia when compared with young mice. Bilobalide has prominent neuroprotective properties in mice of all ages. PMID: 23850645 [PubMed - as supplied by publisher]
Source: Brain Research - July 11, 2013 Category: Neurology Authors: Schwarzkopf TM, Koch KA, Klein J Tags: Brain Res Source Type: research