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Source: Brain Research
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Total 1 results found since Jan 2013.
Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53/SLC7A11-mediated ferroptosis.
This study explores the influence of lentivirus infection-induced ferritin overexpression in hippocampal neuronal injury and death through simulations in August Copenhagen Irish rat models. Twenty-four-hour cerebral ischemia-reperfusion injury was induced in the rats after 90-min middle cerebral artery occlusion (MCAO). Ferritin overexpression was induced through lentivirus infection. The Morris Water Maze (MWM) test and tau hyperphosphorylation test were performed on hippocampal neurons to establish a MCAO model. The effect of ferritin overexpression on hippocampal neuronal death was evaluated using hematoxylin-eosin stai...
Source: Brain Research - December 14, 2020 Category: Neurology Authors: Chen W, Jiang L, Hu Y, Tang N, Liang N, Li XF, Chen YW, Qin H, Wu L Tags: Brain Res Source Type: research
