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Carnosol Inhibits Cerebral Ischemia-Reperfusion Injury by Promoting AMPK Activation
CONCLUSION: Carnosol has a protective effect on ischemic stroke, and this effect is achieved through AMPK activation. Our study demonstrates the protective effect of carnosol on cerebral ischemia-reperfusion injury and provides a new perspective for the clinical treatment of ischemic stroke.PMID:36775042 | DOI:10.1016/j.brainresbull.2023.02.003
Source: Brain Research - February 12, 2023 Category: Neurology Authors: Wen-Chang Xiao Gang Zhou Lu Wan Jun Tu Yong-Jie Yu Zhi-Gang She Chun-Lin Xu Lei Wang Source Type: research

PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPAR γ in cerebral ischemia-reperfusion injury
Brain Res Bull. 2023 Jan 18:S0361-9230(23)00010-2. doi: 10.1016/j.brainresbull.2023.01.007. Online ahead of print.ABSTRACTMitochondrial dysfunction and endoplasmic reticulum (ER) stress occur in ischemic stroke. The disruption of these two organelles can directly lead to cell death through various signaling pathways. Thus, investigation of the associated molecular mechanisms in cerebral ischemia is a prerequisite for stroke treatment. Pleckstrin homology-like domain family A member 1 (PHLDA1) is a multifunctional protein that can modulate mitochondrial function and ER stress in cardiomyocyte and cancer cells. This work stu...
Source: Brain Research - January 21, 2023 Category: Neurology Authors: Yushuang Liu Hanshu Zhao Nan Chen Yuelong Li Zeyang Zheng Zhiyu Sun Zhongling Zhang Source Type: research

β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage
CONCLUSION: BHB can improve the cognitive impairment caused by CCH. The potential mechanisms of BHB may be through reducing neuroinflammation and protecting BBB.PMID:36577190 | DOI:10.1016/j.brainresbull.2022.12.011
Source: Brain Research - December 28, 2022 Category: Neurology Authors: Zhitian Wang Tian Li Miaoyu Du Lei Zhang Linling Xu Hao Song Junjian Zhang Source Type: research

Donepezil promotes neurogenesis via Src signaling pathway in a rat model of chronic cerebral hypoperfusion.
In this study, we investigated whether donepezil could promote SVZ neurogenesis in chronic cerebral hypoperfusion (CCH) injury via Src signaling pathway. In the bilateral carotid artery occlusion (2VO) rat model, we observed more nestin/5-bromo-2'-deoxyuridine (BrdU)-positive cells and doublecortin (DCX)/BrdU-positive cells in the SVZ than that in the sham group. Further, donepezil obviously improved neurologic function after 2VO, induced the greater number of SVZ proliferative NSCs and neuroblasts, and elevated levels of Src, p-FGFR1, p-EGFR, p-Akt and p-Raf in ipsilateral SVZ. Lastly, Src inhibitor KX-01 abolished the be...
Source: Brain Research - March 13, 2020 Category: Neurology Authors: Man J, Cui K, Fu X, Zhang D, Lu Z, Gao Y, Yu L, Li N, Wang J Tags: Brain Res Source Type: research

Time dependent neuroprotection of dexamethasone in experimental focal cerebral ischemia: the involvement of NF- κB pathways.
Time dependent neuroprotection of dexamethasone in experimental focal cerebral ischemia: the involvement of NF-κB pathways. Brain Res. 2018 Sep 21;: Authors: Sun WH, He F, Zhang NN, Zhao ZA, Chen HS Abstract We propose that the neuroprotective effect of glucocorticoid in ischemic damage may be time dependent. The present study was designed to test the proposal and its possible mechanismin cerebral ischemia/reperfusion (I/R) injury model. Reperfusion injury was induced after 120 minutes of middle cerebral artery occlusion (MCAO) in male Sprague-Dawley rats. Atdifferenttimepoints after MCAO, rats were ...
Source: Brain Research - September 21, 2018 Category: Neurology Authors: Sun WH, He F, Zhang NN, Zhao ZA, Chen HS Tags: Brain Res Source Type: research

Proteostasis impairment in ALS.
Abstract In physiological conditions the maintenance of the cellular proteome is a prerequisite for optimal cell functioning and cell survival. Additionally, cells need to constantly sense and adapt to their changing environment and associated stressors. Cells achieve this via a set of molecular chaperones, protein clearance pathways as well as stress-associated signaling networks which work together to prevent protein misfolding, its aggregation and accumulation in subcellular compartments. These processes together form the proteostasis network which helps in maintaining cellular proteostasis. Imbalance or impair...
Source: Brain Research - March 27, 2016 Category: Neurology Authors: Ruegsegger C, Saxena S Tags: Brain Res Source Type: research

p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling.
Abstract Tumor suppressor p53 has recently been reported to have numerous functions independent of tumorigenesis, including neuronal survival during ischemia. The mammalian target of rapamycin (mTOR) signaling pathway plays a central role in the regulation of metabolism, cell growth, development, and cell survival. Our recent work has demonstrated the neuroprotective effects of the mTOR pathway. Considering that p53 is also an important regulator of mTOR, to further clarify the role of p53 and the mTOR signaling pathway in neuronal ischemic-reperfusion injury, we used mouse primary mixed cultured neurons with an o...
Source: Brain Research - February 11, 2015 Category: Neurology Authors: Li X, Gu S, Ling Y, Shen C, Cao X, Xie R Tags: Brain Res Source Type: research

Anti-oxidative nutrient rich diet protects against acute ischemic brain damage in rats.
Abstract We evaluated the neuroprotective effects of an anti-oxidative nutrient rich enteral diet (AO diet) that contained rich polyphenols (catechins and proanthocyanidins) and many other anti-oxidative ingredients. Wistar rats were treated with either vehicle, normal AO diet (containing 100kcal/100ml, catechin 38.75mg/100ml and proanthocyanidin 19mg/100ml, 1ml/day), or high AO diet (containing 10 times the polyphenols of the normal AO diet) for 14 days, and were subjected to 90min of transient middle cerebral artery occlusion. The AO diet improved motor function, reduced cerebral infarction volume, and decreased...
Source: Brain Research - August 28, 2014 Category: Neurology Authors: Yunoki T, Deguchi K, Omote Y, Liu N, Liu W, Hishikawa N, Yamashita T, Abe K Tags: Brain Res Source Type: research

Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats.
Abstract Madecassoside, a triterpenoid derivative isolated from Centella asiatica, exhibits anti-inflammatory and antioxidant activities. We investigated its neuroprotective effect against ischemia-reperfusion (I/R) injury in cerebral neurons in male Sprague-Dawley rats. Madecassoside (6, 12, or 24mg/kg, i.v.) was administered 1h after the start of reperfusion, and neurological deficit score and infarct volume were evaluated 24h later. Neuronal apoptosis was assessed by performing terminal deoxynucleotidyl transferase-mediated dUTP-nick end labeling (TUNEL) staining, and pathological brain damage was estimated by ...
Source: Brain Research - April 12, 2014 Category: Neurology Authors: Luo Y, Yang YP, Liu J, Li WH, Yang J, Sui X, Yuan X, Nie ZY, Liu YQ, Chen D, Lin SH, Wang YA Tags: Brain Res Source Type: research

Combination stroke therapy in the mouse with blood-brain barrier penetrating IgG-GDNF and IgG-TNF decoy receptor fusion proteins.
In conclusion, combination treatment with BBB penetrating IgG-GDNF and IgG-TNFR fusion proteins enhances the therapeutic effect of single treatment with the IgG-GDNF fusion protein following delayed intravenous administration in acute stroke. PMID: 23428543 [PubMed - as supplied by publisher]
Source: Brain Research - February 18, 2013 Category: Neurology Authors: Sumbria RK, Boado RJ, Pardridge WM Tags: Brain Res Source Type: research