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A Comparison of Atrial Fibrillation Monitoring Strategies After Cryptogenic Stroke (from the Cryptogenic Stroke and Underlying AF Trial)
Ischemic stroke cause remains undetermined in 30% of cases, leading to a diagnosis of cryptogenic stroke. Paroxysmal atrial fibrillation (AF) is a major cause of ischemic stroke but may go undetected with short periods of ECG monitoring. The Cryptogenic Stroke and Underlying Atrial Fibrillation trial (CRYSTAL AF) demonstrated that long-term electrocardiographic monitoring with insertable cardiac monitors (ICM) is superior to conventional follow-up in detecting AF in the population with cryptogenic stroke.
Source: The American Journal of Cardiology - June 24, 2015 Category: Cardiology Authors: William C. Choe, Rod S. Passman, Johannes Brachmann, Carlos A. Morillo, Tommaso Sanna, Richard A. Bernstein, Vincenzo Di Lazzaro, Hans-Christoph Diener, Marilyn M. Rymer, Frank Beckers, Jodi Koehler, Paul D. Ziegler, CRYSTAL AF Investigators Tags: Arrhythmias and Conduction Disturbances Source Type: research

Relation of Electrocardiographic Abnormal P-Wave Axis With Stroke Mortality in the General Population
We examined the association of abnormal aPWA with stroke mortality in 7,359 participants (60.0 ± 13.4 years, 51.9% women, 49.8% White) without cardiovascular (CV) disease (CVD) from the Third National Health and Nutrition Examination Survey. aPWA was defined as any value75 °.
Source: The American Journal of Cardiology - August 6, 2022 Category: Cardiology Authors: Muhammad Imtiaz Ahmad, Luqman-Arafath TK, Muhammad Ali Anees, Lin Yee Chen, Elsayed Z. Soliman Source Type: research

Screening for Asymptomatic Atrial Fibrillation While Monitoring the Blood Pressure at Home: Trial of Regular Versus Irregular Pulse for Prevention of Stroke (TRIPPS 2.0)
In conclusion, home screening for asymptomatic AF while taking BP measurements can be performed accurately. This can be used to detect new AF, allowing treatment with anticoagulation to reduce the future risk for stroke.
Source: The American Journal of Cardiology - March 18, 2013 Category: Cardiology Authors: Joseph Wiesel, Saji Abraham, Frank C. Messineo Tags: Arrhythmias and Conduction Disturbances Source Type: research

High Sensitivity C-Reactive Protein and Risk of Stroke in Atrial Fibrillation (From the Reasons for Geographic and Racial Differences in Stroke Study REGARDS)
The relationship between inflammation and prothrombotic state in atrial fibrillation (AF) is well recognized. This suggests a potential role for high sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, in improving prediction of stroke in participants with AF. Cox proportional hazard analysis was used to examine the risk of stroke in 25,841 participants (40% black, 55% women) with and without AF who were enrolled in the REGARDS study between 2003 and 2007. Baseline AF (n=2,132) was ascertained by electrocardiogram and self-reported history of previous physician diagnosis.
Source: The American Journal of Cardiology - September 13, 2016 Category: Cardiology Authors: Farah Z. Dawood, Suzanne Judd, Virginia J. Howard, Nita A. Limdi, James F. Meschia, Mary Cushman, George Howard, David M. Herrington, Elsayed Z. Soliman Source Type: research

Electrocardiographic Morphology-Voltage-P-Wave-Duration (MVP) Score to Select Patients for Continuous Atrial Fibrillation Screening to Prevent Stroke
Morphology-voltage-P-wave-duration (MVP) score combining P-wave duration (PWD), P-wave voltage in lead I (PWVI), and interatrial block (IAB) has been demonstrated to predict atrial fibrillation (AF). Therefore, this study aimed to examine MVP score and its P-wave components as potential predictors of AF screening effects on stroke prevention. This was a secondary analysis of the LOOP Study (Atrial Fibrillation detected by Continuous ECG Monitoring using Implantable Loop Recorder to prevent Stroke in High-risk Individuals) which randomized older persons (aged 70 to 90  years) with additional stroke risk factors to either c...
Source: The American Journal of Cardiology - September 2, 2023 Category: Cardiology Authors: Lucas Yixi Xing, S øren Zöga Diederichsen, Søren Højberg, Derk Krieger, Claus Graff, Morten Salling Olesen, Jonas Bille Nielsen, Axel Brandes, Lars Køber, Ketil Jørgen Haugan, Jesper Hastrup Svendsen Source Type: research

Relation of Atrial Fibrillation to Cognitive Decline (from the REasons for Geographic and Racial Differences in Stroke REGARDS Study)
The association of atrial fibrillation (AF) with cognitive function remains unclear, especially among racially/geographically diverse populations. This analysis included 25,980 black and white adults, aged 48+, from the national REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, free from cognitive impairment and stroke at baseline. Baseline AF was identified by self-reported medical history or electrocardiogram (ECG). Cognitive testing was conducted yearly with the Six Item Screener (SIS) to define impairment and at 2-year intervals to assess decline on: animal naming and letter fluency, Montreal Co...
Source: The American Journal of Cardiology - March 5, 2021 Category: Cardiology Authors: Margie J. Bailey, Elsayed Z. Soliman, Leslie A. McClure, George Howard, Virginia J. Howard, Suzanne E. Judd, Fred Unverzagt, Virginia Wadley, Bonnie C. Sachs, Timothy Hughes Source Type: research

Atrial Myopathy and Ischemic Stroke in Heart Failure With Preserved Ejection Fraction
We examined the hypothesis that atrial myopathy may be associated with ischemic stroke in patients with heart failure with preserved ejection fraction. This is an exploratory, post hoc analysis of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial. Patients with sinus rhythm documented at baseline electrocardiogram and without known AF were included in this analysis.
Source: The American Journal of Cardiology - July 27, 2023 Category: Cardiology Authors: Kassem Farhat, Khaled Elkholey, Zain Ul Abideen Asad, Stavros Stavrakis Source Type: research

Effect of Falls on Frequency of Atrial Fibrillation and Mortality Risk (From the REasons for Geographic And Racial Differences in Stroke REGARDS Study)
It is unclear if persons who have atrial fibrillation (AF) have a higher fall risk compared with those in the general population and if falls increase mortality beyond that observed in AF. A total of 24,117 (mean age=65±9.3; 55% female; 38% black) participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were included. AF was identified from baseline electrocardiogram data and by self-reported history. Falls were considered present if participants reported 2 or more falls within the year prior to the baseline examination.
Source: The American Journal of Cardiology - July 28, 2015 Category: Cardiology Authors: Wesley T. O’Neal, Waqas T. Qureshi, Suzanne E. Judd, C. Barrett Bowling, Virginia J. Howard, George Howard, Elsayed Z. Soliman Source Type: research

Usefulness of the MrWALLETS Scoring System to Predict First Diagnosed Atrial Fibrillation in Patients With Ischemic Stroke
In this study, we searched for echocardiographic parameters associated with first diagnosed AF, to form a scoring system for the identification of patients with AF. We examined 571 patients with ischemic stroke (72.7  ± 13.5 years, 50.6% women), subdivided into 4 groups: documented cause without AF, first diagnosed AF, known paroxysmal AF, and permanent AF. All patients underwent transthoracic echocardiography, brain computed tomography scan, carotid/vertebral ultrasound, and continuous electrocardiographic monitoring.
Source: The American Journal of Cardiology - January 4, 2017 Category: Cardiology Authors: Antonio Muscari, Andrea Bonfiglioli, Luca Faccioli, Marco Ghinelli, Donatella Magalotti, Francesco Manzetto, Anna Pontarin, Giovanni M. Puddu, Luca Spinardi, Eleonora Tubertini, Marco Zoli Tags: Arrhythmias and Conduction Disturbances Source Type: research

Prognostic Usefulness of Left Ventricular Hypertrophy by Electrocardiography in Patients With Atrial Fibrillation (from the Randomized Evaluation of Long-Term Anticoagulant Therapy Study)
It is unknown whether left ventricular hypertrophy (LVH) diagnosis by electrocardiography improves risk stratification in patients with atrial fibrillation (AF). We investigated the prognostic impact of LVH diagnosis by electrocardiography in a large sample of anticoagulated patients with AF included in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) Study. We defined electrographic LVH (ECG-LVH) by strain pattern or Cornell voltage (R wave in aVL plus S wave in V3)>2.0 mV (women) or>2.4 mV (men). LVH prevalence was 22.7%. During a median follow-up of 2.0 years, 303 patients developed a stroke, 778 d...
Source: The American Journal of Cardiology - November 25, 2013 Category: Cardiology Authors: Paolo Verdecchia, Gianpaolo Reboldi, Giuseppe Di Pasquale, Giovanni Mazzotta, Giuseppe Ambrosio, Sean Yang, Janice Pogue, Lars Wallentin, Michael D. Ezekowitz, Stuart J. Connolly, Salim Yusuf, RE-LY Study Investigators Tags: Arrhythmias and Conduction Disturbances Source Type: research

Frequency of Inverted Electrocardiographic T-Waves (Cerebral T-Waves) in Patients with Acute Strokes and Their Relation to Left Ventricular Wall Motion Abnormalities
Transient, symmetric and deep inverted ECG T-waves in the setting of stroke, commonly referred to as cerebral T-waves, are rare and the underlying mechanism is unclear. Our study aimed to test the hypothesis that cerebral T-waves are associated with transient cardiac dysfunction. This retrospective study included 800 patients admitted with the primary diagnosis of hemorrhagic or ischemic stroke. Electrocardiograms were examined for cerebral T waves, defined as T-wave inversion of ≥5 mm depth in ≥4 contiguous precordial leads.
Source: The American Journal of Cardiology - November 14, 2017 Category: Cardiology Authors: Jeremy Stone, Victor Mor-Avi, Agnieszka Ardelt, Roberto M. Lang Source Type: research

Frequency of Inverted Electrocardiographic T Waves (Cerebral T Waves) in Patients With Acute Strokes and Their Relation to Left Ventricular Wall Motion Abnormalities
Transient, symmetric, and deep inverted electrocardiogram (ECG) T waves in the setting of stroke, commonly referred to as cerebral T waves, are rare, and the underlying mechanism is unclear. Our study aimed to test the hypothesis that cerebral T waves are associated with transient cardiac dysfunction. This retrospective study included 800 patients admitted with the primary diagnosis of hemorrhagic or ischemic stroke. ECGs were examined for cerebral T waves, defined as T-wave inversion of ≥5 mm depth in ≥4 contiguous precordial leads.
Source: The American Journal of Cardiology - November 14, 2017 Category: Cardiology Authors: Jeremy Stone, Victor Mor-Avi, Agnieszka Ardelt, Roberto M. Lang Source Type: research

Relation of Interatrial Block to New-Onset Atrial Fibrillation in Patients With Chagas Cardiomyopathy and Implantable Cardioverter-Defibrillators
Chagas cardiomyopathy is an endemic disease in Latin America. A significant proportion of patients develop atrial fibrillation (AF), which may result in stroke and increased morbidity or mortality. Interatrial block (IAB) has been associated with the development of AF in different clinical scenarios. The aim of our study was to determine whether IAB can predict new-onset AF in patients with Chagas cardiomyopathy and implantable cardioverter-defibrillators (ICDs). We conducted a retrospective study of patients with Chagas cardiomyopathy and ICDs from 14 centers in Latin America. Demographics, clinical, and device follow-up ...
Source: The American Journal of Cardiology - March 3, 2014 Category: Cardiology Authors: Andres Enriquez, Diego Conde, Francisco Femenia, Antoni Bayés de Luna, Antonio Ribeiro, Claudio Muratore, Mariana Valentino, Enrique Retyk, Nestor Galizio, Wilma M. Hopman, Adrian Baranchuk Tags: Cardiomyopathy Source Type: research

OP-137 Does Electrocardiographic Diastolic Index Predict Asymptomatic Atrial Fibrillation in Patients with Dual-chamber Pacemaker?
Asymptomatic atrial fibrillation episodes detected by pacemaker is known to increase the risk of systemic embolism and stroke by 2-3 times in patients with dual-chamber pacemaker. Atrial high-rate episodes presence together with duration of episodes is also an important indicator of adverse events. The studies have shown the relationship between the electrocardiographic diastolic index and the development of diastolic dysfunction. The aim of our study was to show the relationship between the ECG index (Tend-P/[PQxAge]) and atrial fibrillation in patients with dual-chamber pacemaker.
Source: The American Journal of Cardiology - March 12, 2015 Category: Cardiology Authors: Ahmet Ilker Tekkesin, Emrah Bozbeyoglu, Ozlem Yildirimturk, Ceyhan Turkkan, Yasin Cakilli, Ahmet Murat, Mert Ilker Hayiroglu, Ahmet Taha Alper Tags: Oral Abstract Source Type: research

Usefulness of Electrocardiographic Patterns at Presentation to Predict Long-Term Risk of Cardiac Death in Patients wtih Hypertrophic Cardiomyopathy
The Objective of this study is to investigate the prognostic significance of 12-lead electrocardiogram (ECG) patterns in a large multicenter cohort of patients with hypertrophic cardiomyopathy (HC). 1004 consecutive patients with HC and a recorded standard ECG (64% men, mean age 50±16 years) were evaluated at 4 Italian centres. The study end-points were sudden cardiac death (SCD) or surrogates, including appropriate implanted cardiac defibrillator discharge and resuscitated cardiac arrest) and major cardiovascular events (including SCD or surrogates and death due to heart failure, cardioembolic stroke or heart transplantation).
Source: The American Journal of Cardiology - May 14, 2016 Category: Cardiology Authors: Elena Biagini, Chiara Pazzi, Iacopo Olivotto, Beatrice Musumeci, Giuseppe Limongelli, Giuseppe Boriani, Giuseppe Pacileo, Vittoria Mastromarino, Maria Letizia Bacchi Reggiani, Massimiliano Lorenzini, Francesco Lai, Alessandra Berardini, Francesca Mingardi Source Type: research

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