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Treatment of hypertension in old patients without previous cardiovascular disease
Conclusion: Blood pressure levels lower than those currently recommended are not harmful among older patients. The association between lower SBP and lesser risk of CVD may instead suggest a beneficial effect of lower SBP.
Source: Journal of Hypertension - September 30, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Blood pressure levels and risk of cardiovascular disease mortality among Japanese men and women: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study)
Conclusion: BP categories at baseline were linearly and positively associated with CVD mortality overall and also among participants not taking antihypertensive medication. A higher risk of mortality from CVD was observed among patients already treated for hypertension with optimal and normal BPs than those with high-normal BP, suggesting the importance of careful monitoring of BP and comorbidities of such patients.
Source: Journal of Hypertension - May 30, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

A retrospective study of arterial stiffness and subsequent clinical outcomes in cancer patients undergoing percutaneous coronary intervention
Conclusion: Atherosclerosis is advanced and accelerated in patients with malignancy, and these patients had significantly higher rates of adverse cardiovascular events, and their risk might be stratified by ABI and baPWV. Registration: University Hospital Medical Information Network-CTR (http://www.umin.ac.jp/ctr/). Identifier: Kumamoto University Malignancy and Atherosclerosis study (UMIN000028652). Public access information: Opt-out materials are available at the following website: http://www.kumadai-junnai.com/home/wp-content/uploads/akusei.pdf.
Source: Journal of Hypertension - March 1, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Heart and vessels Source Type: research

High SBP trajectories are associated with risk of all-cause death in general Chinese population
Conclusion: High SBP trajectories are independent risk factors for all-cause death. Our findings suggest increasing SBP trajectories within the currently designated ‘normal’ range may still increase risk of all-cause death.
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Effect of total, domain-specific, and intensity-specific physical activity on all-cause and cardiovascular mortality among hypertensive adults in China
Objectives: We aimed to prospectively examine the associations of total, domain-specific, and intensity-specific physical activity with all-cause and cardiovascular mortality among Chinese hypertensive adults. Methods: We performed a prospective cohort study in 150 391 hypertensive participants aged 30–79 years from the China Kadoorie Biobank study of 512 891 participants recruited from 10 diverse areas across China during 2004–2008. Participants with heart disease, stroke, chronic obstructive pulmonary disease, and cancer at baseline were excluded. Results: During 1069 863 person-years of follow-up (medi...
Source: Journal of Hypertension - March 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Lifestyle Source Type: research

A stop-codon of the phosphodiesterase 11A gene is associated with elevated blood pressure and measures of obesity
Objective: To identify stop-codon variants associated with blood pressure (BP). Methods: Illumina exome chip was genotyped in 5453 individuals of the population-based Malmö Diet and Cancer Study. We compared BP levels between carriers and noncarriers of all stop-codon variants found in at least 10 individuals and characterized these further based on literature evidence of functionality. Next, the association to ischemic stroke was evaluated in 2278 cases of ischemic stroke and 5969 controls. Results: We identified 19 stop-codon variants with nominally significant BP associations (P 
Source: Journal of Hypertension - January 30, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Genetic aspects Source Type: research

Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death
Conclusion:The NEDD4L salt sensitivity-associated genotype was associated with higher blood pressure, which may translate into increased risk for CVD morbidity and mortality. Interestingly, there was no association with stroke suggesting that the association is partially blood pressure independent.
Source: Journal of Hypertension - January 20, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Genetic aspects Source Type: research

Long-term alcohol consumption is an independent risk factor of hypertension development in northern China: evidence from Kailuan study
Objective:The purpose of the present study was to determine the impact of alcohol consumption on the incidence of hypertension. Methods:A total of 32 389 male coal mine workers from Kailuan Coal Group in northern China (Kailuan study), free of hypertension, myocardial infarction, stroke, transient ischemia attack and cancer, were followed up every 2 years for 4 years. The average alcohol intake during the past year was reported as baseline. Results:During 4 years of follow-up, 9151 out of 32 389 workers developed hypertension categorically. At the end of the follow-up, the cumulative incidence of hypertension in relati...
Source: Journal of Hypertension - November 13, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research