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Source: American Heart Journal
Condition: Heart Disease

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Total 47 results found since Jan 2013.

Comparison of Risk Scores for the Prediction of Stroke in African Americans: Findings from the Jackson Heart Study
Conclusions Both scores were associated with incident stroke in a dose–response fashion; however, the CVD risk model was more discriminating than the CVH model. The CVH score may still be preferable for its simplicity in application to broad patient populations and public health efforts.
Source: American Heart Journal - April 16, 2016 Category: Cardiology Source Type: research

C-reactive Protein and Stroke Risk in Blacks and Whites: the REasons for Geographic and Racial Differences in Stroke Cohort
ConclusionsCRP may not be equally useful in stroke risk assessment in blacks and whites. Confirmation, similar study for coronary heart disease, and identification of reasons for these racial differences require further study.
Source: American Heart Journal - August 13, 2019 Category: Cardiology Source Type: research

Improving outcomes in patients with atrial fibrillation: Rationale and design of the Early treatment of Atrial fibrillation for Stroke prevention Trial
Conclusion: EAST will determine whether rhythm control therapy, when applied early after the initial diagnosis of AF, can prevent cardiovascular complications associated with AF.
Source: American Heart Journal - August 1, 2013 Category: Cardiology Authors: Paulus Kirchhof, Günter Breithardt, A. John Camm, Harry J. Crijns, Karl-Heinz Kuck, Panos Vardas, Karl Wegscheider Tags: Trial Design Source Type: research

Diabetes, diabetes severity and coronary heart disease risk equivalence REasons for Geographic and Racial Differences in Stroke (REGARDS)
Conclusions Participants with diabetes had lower risk of CHD events than those with prevalent CHD. However, participants with severe diabetes had similar risk as those with prevalent CHD. Diabetes severity may need consideration when deciding whether diabetes is a CHD risk equivalent.
Source: American Heart Journal - August 11, 2016 Category: Cardiology Source Type: research

Diabetes, diabetes severity, and coronary heart disease risk equivalence: REasons for Geographic and Racial Differences in Stroke (REGARDS)
Conclusions Participants with diabetes had lower risk of CHD events than did those with prevalent CHD. However, participants with severe diabetes had similar risk to those with prevalent CHD. Diabetes severity may need consideration when deciding whether diabetes is a CHD risk equivalent.
Source: American Heart Journal - September 5, 2016 Category: Cardiology Source Type: research

Association of 25-hydroxyvitamin D with incident coronary heart disease in the reasons for geographic and racial differences in stroke (REGARDS) study
ConclusionsLower plasma 25(OH)D concentrations were associated with higher risk of incident CHD. In contrast to prior studies, these associations did not differ by race.
Source: American Heart Journal - August 21, 2019 Category: Cardiology Source Type: research

Association of all-cause and cardiovascular mortality with prehypertension: A meta-analysis
Background: Studies of prehypertension and mortality are controversial after adjusting for other cardiovascular risk factors. This meta-analysis sought to evaluate the association of prehypertension with all-cause and cardiovascular disease (CVD) mortality.Methods: The PubMed, EMBASE, Cochrane Library databases, and conference proceedings were searched for studies with data on prehypertension and mortality. The relative risks (RRs) of all-cause, CVD, coronary heart disease (CHD), and stroke mortality were calculated and presented with 95% CIs. Subgroup analyses were conducted according to blood pressure, age, gender, ethni...
Source: American Heart Journal - November 8, 2013 Category: Cardiology Authors: Yuli Huang, Liang Su, Xiaoyan Cai, Weiyi Mai, Sheng Wang, Yunzhao Hu, Yanxian Wu, Hongfeng Tang, Dingli Xu Tags: Hypertension Source Type: research

Effects of nonpersistence with medication on outcomes in high-risk patients with cardiovascular disease
Background: The impact of nonpersistence on events and of events on persistence is unclear. We studied the effects of nonpersistence on outcomes and events on nonadherence in a randomized placebo controlled trial in 40 countries on 25,620 patients.Methods: In the ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET), persistent patients (n = 20,991) were compared with individuals who had permanently stopped study medications (n = 4,629).Results: Older age, female gender, less physical activity, less education, and history of stroke/transient ischemic attack, depression, and diabetes we...
Source: American Heart Journal - June 26, 2013 Category: Cardiology Authors: Michael Böhm, Helmut Schumacher, Ulrich Laufs, Peter Sleight, Roland Schmieder, Thomas Unger, Koon Teo, Salim Yusuf Tags: Acute Ischemic Heart Disease Source Type: research

Individual Components of the Romhilt-Estes Left Ventricular Hypertrophy Score Differ in Their Prediction of Cardiovascular Events: the Atherosclerosis Risk in Communities (ARIC) Study
Conclusions The R-E score is predictive of CVD outcomes. The six R-E score components differ in their associations with different CVD outcomes, indicating that they may be electrical biomarkers of different physiological events within the myocardium. Graphical abstract
Source: American Heart Journal - October 4, 2015 Category: Cardiology Source Type: research

Temporal trends in sudden unexpected death in a general population: The Hisayama Study
Background: Studies addressing the temporal trends in the prevalence of sudden unexpected death (SUD) and its underlying causes in the general population are limited.Methods: Among a total of 1934 residents aged ≥20 years of the town of Hisayama, Japan, who died of endogenous causes of death and underwent autopsy examination (autopsy rate 78.5%) from 1962 to 2009, 204 were determined to be cases of SUD within 24 hours.Results: The trend in the age- and sex-adjusted prevalence of SUD among all autopsy subjects was stable over four 12-year periods (13.1% in 1962-1973, 13.4% in 1974-1985, 15.0% in 1986-1997, and 14.6% in 19...
Source: American Heart Journal - April 8, 2013 Category: Cardiology Authors: Masaharu Nagata, Toshiharu Ninomiya, Yasufumi Doi, Jun Hata, Fumie Ikeda, Naoko Mukai, Kazuhiko Tsuruya, Yoshinao Oda, Takanari Kitazono, Yutaka Kiyohara Tags: Acute Ischemic Heart Disease Source Type: research

Design of the liraglutide effect and action in diabetes: Evaluation of cardiovascular outcome results (LEADER) trial
Conclusions: LEADER commenced in September 2010, and enrollment concluded in April 2012. There were 9,340 patients enrolled at 410 sites in 32 countries. The mean age of patients was 64.3 ± 7.2 years, 64.3% were men, and mean body mass index was 32.5 ± 6.3 kg/m2. There were 7,592 (81.3%) patients with prior CVD and 1,748 (18.7%) who were high risk but without prior CVD. It is expected that LEADER will provide conclusive data regarding the cardiovascular safety of liraglutide relative to the current standard of usual care for a global population of patients with T2DM.
Source: American Heart Journal - October 4, 2013 Category: Cardiology Authors: Steven P. Marso, Neil R. Poulter, Steven E. Nissen, Michael A. Nauck, Bernard Zinman, Gilbert H. Daniels, Stuart Pocock, William M. Steinberg, Richard M. Bergenstal, Johannes F.E. Mann, Lasse Steen Ravn, Kirstine Brown Frandsen, Alan C. Moses, John B. Bus Tags: Trial Design Source Type: research

Six-year change in high-sensitivity C-reactive protein and risk of diabetes, cardiovascular disease, and mortality
Conclusions Large increases or sustained elevations in hs-CRP over a six-year period were associated with a subsequent increased risk of diabetes; and persons with sustained elevations in hs-CRP were at the highest risk of CVD and mortality. Two measurements of hs-CRP are better than one for characterizing risk and large increases are particularly prognostic.
Source: American Heart Journal - April 22, 2015 Category: Cardiology Source Type: research