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Total 826 results found since Jan 2013.
Effects of early mobilization on short-term blood pressure variability in acute intracerebral hemorrhage patients: A protocol for randomized controlled non-inferiority trial
Conclusions:
It is safe to implement the EM protocol within 24 to 72 hour of onset for mild-moderate ICH patients during the acute phase.
Source: Medicine - May 28, 2021 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Clinical characteristics, triggering etiologies, and response of plasmapheresis in thrombotic microangiopathy in Taiwan
This study indicated the spectrum of underlying causes, extra-renal characteristics, and the response to plasmapheresis of patients with TMA in Taiwan. Of note, the poor clinical outcomes of plasmapheresis in patients with TMA might highlight the masked underlying etiology or worse disease condition that should be noticed.
Source: Medicine - May 21, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Tuina plus acupuncture for post-stroke depression: A protocol for systematic review and meta-analysis
Conclusion:
This systematic review will provide evidence to determine whether Tuina plus acupuncture is an effective and safe intervention for patients with post-stroke depression.
Ethics and dissemination:
The protocol of the systematic review does not require ethical approval because it does not involve humans. This article will be published in peer-reviewed journals and presented at relevant conferences.
Systematic review registration:
INPLASY202140098
Source: Medicine - May 21, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Efficacy and safety of ticagrelor monotherapy in patients following percutaneous coronary intervention: A systematic review and meta-analysis
Background:
We aimed to systematically evaluate the efficacy and safety ticagrelor monotherapy following percutaneous coronary intervention.
Methods:
Online databases were searched for relevant studies (published between the years 2015 and 2020) comparing 1-month Dual antiplatelet therapy (DAPT) followed by 23-month ticagrelor monotherapy with 12-month DAPT followed by 12-month aspirin monotherapy following percutaneous coronary intervention. Primary outcomes assessed efficacy whereas secondary outcomes assessed safety. Odds ratios (OR) with 95% confidence intervals (CIs) based on a random effect model were calc...
Source: Medicine - May 21, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Predictors of bleeding event among elderly patients with mechanical valve replacement using random forest model: A retrospective study
Available classification tools and risk factors predicting bleeding events in elderly patients after mechanical valve replacement may not be suitable in Asian populations. Thus, we aimed to identify an accurate model for predicting bleeding in elderly patients receiving warfarin after mechanical valve replacement in a Korean population. In this retrospective cohort study, a random forest model was used to determine factors predicting bleeding events among 598 participants. Twenty-two descriptors were selected as predictors for bleeding. Steroid use was the most important predictor of bleeding events, followed by labile int...
Source: Medicine - May 14, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Preliminary screening for sarcopenia and related risk factors among the elderly
This study included 200 participants aged 65 or over living in Taiwan, but excluded the following:
1.people with neuromuscular diseases affecting limb function and balance (such as stroke, Parkinson disease, spinal stenosis, and peripheral nerve compression);2.people with fractures in the lower extremities or with arthritis, which could affect mobility;3.people with pacemakers or other medical implant devices; and4.people who declined to participate in the research and people who could not complete all aspects of the research.
The prevalence of sarcopenia in the elderly community is approximately 6.0%. It is less pre...
Source: Medicine - May 14, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Study on optimization and evaluation system of traditional Chinese medicine rehabilitation program for swallowing disorder after stroke
This article presents a study protocol for a multicenter, randomized, controlled trial for evaluating the efficacy of acupuncture in treating post-stroke dysphagia.
Methods/design:
A randomized controlled trial will be conducted in three hospitals in Heilongjiang, Changchun, and Beijing. A total of 252 patients with post-stroke swallowing ability will be randomly divided into two groups; specifically, the experimental group, which will receive acupuncture treatment, and the control group, which will undergo rehabilitation training for 2 weeks. The main results will be evaluated using the standard swallowing function...
Source: Medicine - May 14, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
The diagnostic reliability and validity of noninvasive imaging modalities to assess leptomeningeal collateral flow for ischemic stroke patients: A systematic review and meta-analysis
Leptomeningeal collateral flow (LMF) is associated with infarct area and clinical outcome for ischemic stroke patients. Although LMF can be detected by multiple imaging methods, but their diagnostic performance is uncertain.
The aim of this study was to evaluate the diagnostic validity or reliability of noninvasive image methods in assessing LMF.
Databases included PubMed, Web of Science, Embase, and Cochrane Library.
Original observational cohort studies.
Ischemic stroke patients.
Different noninvasive image methods to assess LMF.
Newcastle–Ottawa Scale to evaluate the quality of the studies; forest pl...
Source: Medicine - May 7, 2021 Category: Internal Medicine Tags: Research Article: Meta-Analysis of Observational Studies in Epidemiology Source Type: research
Non-pharmacological intervention for rehabilitation of post-stroke spasticity: A protocol for systematic review and network meta-analysis
Conclusion:
The results of this study will provide evidence to judge whether non-pharmacological interventions are effective interventions for patients with post-stroke spasticity.
Ethics and dissemination:
The results of this meta-analysis and meta-regression will be disseminated through publication in a peer-reviewed journal and presented at a relevant conference. The data used in the network meta-analysis did not contain individual patient data. Therefore, ethical approval was not required.
INPLASY registration number:
INPLASY202140059
Source: Medicine - May 7, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Comparison of gait recovery patterns according to the paralyzed side in stroke patients: An observational study based on a retrospective chart review (STROBE compliant)
Gait rehabilitations have been abundantly performed for post-stroke patients, because gait is the most important factor for the return of post-stroke patients to daily life. However, conventional uniform gait rehabilitations tend to be tedious and reduce motivation. The aim of this study was to contribute to the development of personalized rehabilitation of gait by identifying differences in gait recovery pattern according to the paralyzed side of post-stroke patients.
The gait analysis was performed on stroke patients who are right-handed and can walk independently. We retrospectively analyzed the results of pelvic mov...
Source: Medicine - April 23, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Effectiveness and safety of traditional Chinese medicine in the treatment of senile hypotension: A protocol for systematic review and meta-analysis
Conclusions:
The conclusions of our study will provide an evidence to judge whether TCM is an effective and safe intervention for patients with senile hypotension.
Ethics and dissemination:
This systematic review will be disseminated in a peer-reviewed journal or presented at relevant conferences. It is not necessary for a formal ethical approval because the data are not individualized.
Trial registration number:
INPLASY2020110091.
Source: Medicine - April 23, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Determinants of life satisfaction among stroke survivors 1 year post stroke
This study recruited 376 stroke survivors (244 men and 132 women, mean age: 57 years) 1 year following stroke. Data on participants’ LS (measured using the Life Satisfaction Questionnaire [LiSat-11]), socio-demographics, and stroke-related variables were collected.
Univariate analysis showed that LS and the 10 specific domains were not associated with the patients’ gender or stroke type; however, age at onset, marital status, and vocational situation were significantly associated with some domains in LiSat-11 (Spearman's rho = 0.42–0.87; all P
Source: Medicine - April 23, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Analysis of individualized antiplatelet therapy for patients of acute coronary syndrome after percutaneous coronary intervention under the guidance of platelet function: A one-center retrospective cohort study
There is controversy in clinical application of antiplatelet drugs by monitoring platelet function. Therefore, we explored whether early and dynamic medication could bring better clinical outcomes for patients under the guidance of platelet function tests (PFT).
In this retrospective cohort study, we analyzed the prognostic events of 1550 patients with acute coronary syndrome (ACS) at Tianjin People's Hospital in China. They received dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) from January 2017 to December 2018. The primary endpoint was based on the Bleeding Academic Research Consorti...
Source: Medicine - April 23, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Traditional East Asian herbal medicines for the treatment of poststroke constipation: A protocol for systematic review and meta analysis
Conclusion:
Our systematic review will provide evidence to determine whether herbal medicines can be effective interventions for patients with post-stroke constipation.
Ethics and dissemination:
Ethical approval is not required, as this study was based on a review of published research. This review will be published in a peer-reviewed journal and disseminated electronically and in print.
Trial registration number:
Research registry reviewregistry1117
Source: Medicine - April 16, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Effects of continuous use of metformin on cardiovascular outcomes in patients with type 2 diabetes after acute myocardial infarction: A protocol for systematic review and meta-analysis
Conclusions:
This study expects to provide credible and scientific evidence for the efficacy and safety of metformin on cardiovascular outcomes after AMI in patients with T2DM.
Registration number:
10.17605/OSF.IO/S3MBP.
Source: Medicine - April 16, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
