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PR ‐957 mediates neuroprotection by inhibiting Th17 differentiation and modulating cytokine production in a mouse model of ischaemic stroke
Clinical&Experimental Immunology, EarlyView.
Source: Clinical and Experimental Immunology - April 23, 2018 Category: Allergy & Immunology Authors: Y.Guo , X.Chen , D.Li , H.Liu , Y.Ding , R.Han , Y.Shi , X.Ma Source Type: research

The effect of gender and genetic polymorphisms on matrix metalloprotease (MMP) and tissue inhibitor (TIMP) plasma levels in different infectious and non‐infectious conditions
In conclusion, male gender and MMP‐3(‐1612 5A/6A) 6A allele carriage increased MMP‐3 plasma levels significantly, especially in patients with severe bacterial sepsis. This confounding gender effect needs to be addressed when evaluating MMP‐3 plasma levels in any infectious or non‐infectious condition.
Source: Clinical and Experimental Immunology - September 11, 2015 Category: Allergy & Immunology Authors: J. Collazos, V. Asensi, G. Martin, A. H. Montes, T. Suárez‐Zarracina, E. Valle‐Garay Tags: Original Article Source Type: research

The effect of gender and genetic polymorphisms on MMPs and TIMPs plasma levels in different infectious and non‐infectious conditions^
In conclusion, male gender and MMP‐3(‐1612 5A/6A) 6A allele carriage significantly increased MMP‐3 plasma levels, especially in patients with severe bacterial sepsis. This confounding gender effect needs to be addressed when evaluating MMP‐3 plasma levels in any infectious or non‐infectious condition. This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Immunology - July 22, 2015 Category: Allergy & Immunology Authors: Julio Collazos, Víctor Asensi, Guadalupe Martin, A. Hugo Montes, Tomás Suárez‐Zarracina, Eulalia Valle‐Garay Tags: Original Article Source Type: research

Cerebral vasculitis in adults: what are the steps in order to establish the diagnosis? Red flags and pitfalls
Summary Cerebral vasculitis is a rare cause of juvenile stroke. It may occur as primary angiitis of the central nervous system (PACNS) or as CNS manifestation in the setting of systemic vasculitis. Clinical hints for vasculitis are headache, stroke, seizures, encephalopathy and signs of a systemic inflammatory disorder. Diagnostic work‐up includes anamnesis, whole body examination, laboratory and cerebral spinal fluid (CSF) studies, magnetic resonance imaging (MRI), angiography and brain biopsy. Due to the rarity of the disease, exclusion of more frequent differential diagnoses is a key element of diagnostic work ‐up. ...
Source: Clinical and Experimental Immunology - February 4, 2014 Category: Allergy & Immunology Authors: P. Berlit, M. Kraemer Tags: Review Article Source Type: research

Neuroprotective effects of argatroban and C5a receptor antagonist (PMX53) following intracerebral haemorrhage
Summary Intracerebral haemorrhage (ICH) is a subtype of stroke that associated with neurological dysfunction and inflammation, which may be ameliorated by a neuroprotective strategy targeting the complement cascade. The protective effect of C5a‐receptor antagonist (PMX53) solely and in combination with thrombin antagonist (argatroban) was investigated in the ICH mouse model, respectively. Adult male C57BL/6J wild‐type (WT) mice and C3–/– mice were randomized to receive PMX53/argatroban 1, 3 and 5 days after ICH. A double injection technique was used to infuse 25 μl of autologous whole blood into the right striat...
Source: Clinical and Experimental Immunology - January 3, 2014 Category: Allergy & Immunology Authors: G. Li, R.‐M. Fan, J.‐L. Chen, C.‐M. Wang, Y.‐C. Zeng, C. Han, S. Jiao, X.‐P. Xia, W. Chen, S.‐T. Yao Tags: Original Article Source Type: research

Cerebral vasculitis in adults ‐ What are the steps in order to establish the diagnosis? Red flags and pitfalls
Abstract Cerebral vasculitis is a rare cause of juvenile stroke. It may occur as primary angiitis of the CNS or as CNS manifestation in the setting of systemic vasculitis. Clinical hints for vasculitis are headache, stroke, seizures, encephalopathy and signs of a systemic inflammatory disorder. Diagnostic work up includes anamnesis, whole body examination, laboratory and CSF studies, MRI, angiography and brain biopsy. Due to the rarity of the disease exclusion of more frequent differential diagnoses is a key element of diagnostic work up. This review summarizes the steps that lead to the diagnosis of cerebral vasculitis an...
Source: Clinical and Experimental Immunology - October 12, 2013 Category: Allergy & Immunology Authors: Peter Berlit, Markus Kraemer Tags: Review Article Source Type: research

Neuroprotective effects of Argatroban and C5a receptor antagonist (PMX53) following intracerebral hemorrhage
Abstract Intracerebral hemorrhage (ICH) is a subtype of stroke that associated with neurological dysfunction and inflammation, which may be ameliorated by a neuroprotective strategy targeting the complement cascade. Protective effect of C5a‐receptor antagonist (PMX53) solely and in combination with thrombin antagonist (argatroban) was investigated in ICH mouse model, respectively. Adult male C57BL/6J WT mice and C3‐/‐ mice were randomized to receive PMX53/argatroban 1, 3 and 5 days posterior to ICH. A double injection technique was used to infuse 25 μL of autologous whole blood into the right striatum. The mice in s...
Source: Clinical and Experimental Immunology - October 11, 2013 Category: Allergy & Immunology Authors: Gang Li, Rui‐Ming Fan, Jia‐Lin Chen, Chang‐Ming Wang, You‐Chao Zeng, Chong Han, Song Jiao, Xiang‐Ping Xia, Wei Chen, Sheng‐Tao Yao Tags: Original Article Source Type: research

Plasma levels of mannan‐binding lectin (MBL)‐associated serine proteases (MASPs) and MBL‐associated protein in cardio‐ and cerebrovascular diseases
Summary Growing evidence suggests a prominent role of the complement system in the pathogenesis of cardio‐ and cerebrovascular diseases (CVD). Mannan‐binding lectin‐associated serine proteases (MASPs) MASP‐1 and MASP‐2 of the complement lectin pathway contribute to clot formation and may represent an important link between inflammation and thrombosis. MBL‐associated protein MAp44 has shown cardio‐protective effects in murine models. However, MAp44 has never been measured in patients with CVD and data on MASP levels in CVD are scarce. Our aim was to investigate for the first time plasma levels of MAp44 and MAS...
Source: Clinical and Experimental Immunology - February 25, 2013 Category: Allergy & Immunology Authors: Vera Frauenknecht, Steffen Thiel, Line Storm, Niklaus Meier, Marcel Arnold, Jean‐Paul Schmid, Hugo Saner, Verena Schroeder Tags: Original Article Source Type: research