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Irisin Protects Cerebral Neurons from Hypoxia/Reoxygenation via Suppression of Apoptosis and Expression of Pro-Inflammatory Cytokines
Conclusion: Irisin exerts profound neuroprotective and anti-inflammatory effects on H/R-stimulated cerebral neurons by inhibiting the MAPK signaling activation. Therefore, irisin may serve as a potential drug for the treatment of patients with ischemic stroke.Neuroimmunomodulation 2022;29:425 –432
Source: Neuroimmunomodulation - June 15, 2022 Category: Allergy & Immunology Source Type: research

Role of Immune and Inflammatory Mechanisms in Stroke: A Review of Current Advances
Stroke accounts for a large proportion of morbidity and mortality burden in China. Moreover, there is a high prevalence of the leading risk factors for stroke, including hypertension and smoking. Understanding the underlying mechanisms and developing effective therapeutic interventions for patients with stroke is a key imperative. The pathophysiology of stroke involves a complex interplay between the immune and inflammatory mechanisms. Focal brain inflammation triggered by neuronal cell death and the release of factors such as damage-associated molecular patterns can further exacerbate neuronal injury; in addition, impairm...
Source: Neuroimmunomodulation - May 31, 2022 Category: Allergy & Immunology Source Type: research

Analysis of Resting Energy Consumption and Its Influencing Factors in Stroke Patients with Severe Neurological Diseases: A Retrospective Clinical Study
Conclusion: Metabolic vehicle assay has a certain clinical value in accurately evaluating the metabolic needs and feeding level of patients.Neuroimmunomodulation
Source: Neuroimmunomodulation - May 25, 2022 Category: Allergy & Immunology Source Type: research

Zuogui Pill Attenuates Neuroinflammation and Improves Cognitive Function in Cerebral Ischemia Reperfusion-Injured Rats
Conclusion: This study provided protective roles of ZGP on cell viability and apoptosis induced by OGD/R. In addition, ZGP played protective roles on neuroinflammation and cognitive function in rats.Neuroimmunomodulation
Source: Neuroimmunomodulation - November 4, 2021 Category: Allergy & Immunology Source Type: research

The Exosomal MicroRNA Profile Is Responsible for the Mesenchymal Stromal Cell Transplantation-Induced Improvement of Functional Recovery after Stroke in Rats
Conclusion: We confirmed that MSC transplantation repaired stroke-induced functional impairments in rats by regulating various pathways associated with nervous system protection and MSC differentiation through the deregulation of exosomal miRNAs.Neuroimmunomodulation
Source: Neuroimmunomodulation - September 17, 2021 Category: Allergy & Immunology Source Type: research

PKM2 Aggravates Cerebral Ischemia Reperfusion-Induced Neuroinflammation via TLR4/MyD88/TRAF6 Signaling Pathway
Conclusions: Knockdown of PKM2 attenuated cerebral I/R injury through HMGB1-mediated TLR4/MyD88/TRAF6 expression change, providing a potential target for cerebral I/R injury treatment.Neuroimmunomodulation
Source: Neuroimmunomodulation - March 19, 2021 Category: Allergy & Immunology Source Type: research

Scopoletin Attenuates Intracerebral Hemorrhage-Induced Brain Injury and Improves Neurological Performance in Rats
Conclusion: Our investigations propose that the effectiveness of scopoletin in improving acute neurological function after ICH is promising, and this could be a lead molecule for the development of treatment plans in ICH treatment.Neuroimmunomodulation
Source: Neuroimmunomodulation - March 19, 2021 Category: Allergy & Immunology Source Type: research

Depletion of CD11c+ Cells Does Not Influence Outcomes in Mice Subjected to Transient Middle Cerebral Artery Occlusion
Conclusions: We show, for the first time, that CD11c+ cell depletion does not influence stroke volume in a mouse model of focal cerebral ischemia. Nevertheless, given the unspecificity of the CD11c surface antigen for DC, mouse models that allow a more selective depletion of DC are needed to investigate the role of DC in stroke pathophysiology.Neuroimmunomodulation
Source: Neuroimmunomodulation - October 31, 2017 Category: Allergy & Immunology Source Type: research

Depletion of CD11c < sup > + < /sup > Cells Does Not Influence Outcomes in Mice Subjected to Transient Middle Cerebral Artery Occlusion
Conclusions: We show, for the first time, that CD11c+ cell depletion does not influence stroke volume in a mouse model of focal cerebral ischemia. Nevertheless, given the unspecificity of the CD11c surface antigen for DC, mouse models that allow a more selective depletion of DC are needed to investigate the role of DC in stroke pathophysiology.Neuroimmunomodulation
Source: Neuroimmunomodulation - October 30, 2017 Category: Allergy & Immunology Source Type: research

Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke
Conclusion: We demonstrated that minocycline can ameliorate ischemia-induced brain damage via inhibiting NLRP3 inflammasome activation.Neuroimmunomodulation
Source: Neuroimmunomodulation - November 15, 2016 Category: Allergy & Immunology Source Type: research

The Possible Role of Toll-Like Receptor 4 in the Pathology of Stroke
This article reviews recent information regarding the impact of TLR4 on the pathogenicity of stroke.Neuroimmunomodulation
Source: Neuroimmunomodulation - June 8, 2016 Category: Allergy & Immunology Source Type: research

Role of N-Terminal Pro-B-Type Natriuretic Peptide, High-Sensitivity C-Reactive Protein, and Inteleukin-6 in Predicting a Poor Outcome after a Stroke
Conclusions: In acute stroke patients, greater NT-proBNP and hsCRP serum concentrations are independently associated with greater clinical stroke severity. Elevated concentrations of IL-6 and hsCRP are associated with worse functional and cognitive outcomes at discharge, respectively.Neuroimmunomodulation
Source: Neuroimmunomodulation - May 8, 2015 Category: Allergy & Immunology Source Type: research