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Source: Acta Pharmacologica Sinica
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Total 122 results found since Jan 2013.
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog
In this study, we investigated the mechanisms underlying the angiogenesis-promoting effects of NBP in ischemic stroke models in vitro and in vivo. OGD/R model was established in human umbilical vein endothelial cells (HUVECs) and human brain microvascular endothelial cells (HBMECs), while the tMCAO model was established in mice. The cells were pretreated with NBP (10, 50, 100 µM); the mice were administered NBP (4, 8 mg/kg, i.v.) twice after tMCAO. We showed that NBP treatment significantly stimulated angiogenesis by inducing massive production of angiogenic growth factors VEGFA and CD31 in both in vitro and in vivo model...
Source: Acta Pharmacologica Sinica - August 14, 2023 Category: Drugs & Pharmacology Authors: Mei-Jie Dai Xing-Xing Gui Shu-Miao Jia Shu-Ting Lv Hao Dou Wei Cui Source Type: research
A novel small-molecular CCR5 antagonist promotes neural repair after stroke
In this study we characterized the therapeutic potential of a novel CCR5 antagonist A14 in treating ischemic stroke mice. A14 was discovered in screening millions compounds in the Chemdiv library based on the molecular docking diagram of CCR5 and maraviroc. We found that A14 dose-dependently inhibited the CCR5 activity with an IC50 value of 4.29 μM. Pharmacodynamic studies showed that A14 treatment exerted protective effects against neuronal ischemic injury both in vitro and vivo. In a SH-SY5Y cell line overexpressing CCR5, A14 (0.1, 1 μM) significantly alleviated OGD/R-induced cell injury. We found that the expression o...
Source: Acta Pharmacologica Sinica - May 17, 2023 Category: Drugs & Pharmacology Authors: Qing-Lin Wu Li-Yuan Cui Wen-Yu Ma Sha-Sha Wang Zhao Zhang Zhong-Ping Feng Hong-Shuo Sun Shi-Feng Chu Wen-Bin He Nai-Hong Chen Source Type: research
RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism
In this study, we investigated the molecular mechanisms underlying RIPK1-mediated astrocyte injury in vitro and in vivo. Primary cultured astrocytes were transfected with lentiviruses and then subjected to oxygen and glucose deprivation (OGD). In a rat model of permanent middle cerebral artery occlusion (pMCAO), lentiviruses carrying shRNA targeting RIPK1 or shRNA targeting heat shock protein 70.1B (Hsp70.1B) were injected into the lateral ventricles 5 days before pMCAO was established. We showed that RIPK1 knockdown protected against OGD-induced astrocyte damage, blocked the OGD-mediated increase in lysosomal membrane per...
Source: Acta Pharmacologica Sinica - April 13, 2023 Category: Drugs & Pharmacology Authors: Hua-Ping Du Yi Guo Yong-Ming Zhu De-Fei Gao Bo Lin Yuan Liu Yuan Xu Ali Said Taous Khan Li-Jun Liu Jian-Jun Zhu Yong Ni Hui-Ling Zhang Source Type: research
Angiogenesis after ischemic stroke
Acta Pharmacol Sin. 2023 Feb 24. doi: 10.1038/s41401-023-01061-2. Online ahead of print.ABSTRACTOwing to its high disability and mortality rates, stroke has been the second leading cause of death worldwide. Since the pathological mechanisms of stroke are not fully understood, there are few clinical treatment strategies available with an exception of tissue plasminogen activator (tPA), the only FDA-approved drug for the treatment of ischemic stroke. Angiogenesis is an important protective mechanism that promotes neural regeneration and functional recovery during the pathophysiological process of stroke. Thus, inducing angio...
Source: Acta Pharmacologica Sinica - February 24, 2023 Category: Drugs & Pharmacology Authors: Jie Fang Zhi Wang Chao-Yu Miao Source Type: research
