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20 years of Modifying Stroke Risk in Sickle Cell Disease (SCD) Patients: a Single Center Experience of Bone Marrow Transplant (BMT) in SCD (P6.256)
Conclusions:While BMT is curative for SCD, the impact on cerebral vasculopathy and ongoing stroke risk is unknown. Data from this sample suggests that BMT is associated with stabilization but not resolution of vasculopathy and dramatic reduction of stroke after the first year.Study Supported by:N/ADisclosure: Dr. Carpenter has nothing to disclose. Dr. Farias Moeller has nothing to disclose. Dr. Abraham has nothing to disclose. Dr. Khademian has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Carpenter, J., Moeller, R. F., Abraham, A., Khademian, Z. Tags: Non-Atherosclerotic Angiopathies and Cerebral Venous Thrombosis Source Type: research

Stroke versus non-stroke neurological complications after cardiac transplant (P4.299)
Conclusions:Neurological complications after CT in our population reach nearly a quarter of patients, similar to or even lower than in previous studies.4.3% of patients developed stroke, ischemic subtype.Pre- and perioperative variables do not differ between both groups, except from ischemic cardiomyopathy as the cause of heart failure being it more frequent in the stroke group.Disclosure: Dr. Vazquez has nothing to disclose. Dr. Thomson has nothing to disclose. Dr. Molina Melendres has nothing to disclose. Dr. Nadile has nothing to disclose. Dr. Gonzalez Toledo has nothing to disclose. Dr. Claverie has nothing to disclose...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Vazquez, G., Thomson, A., Melendres, J. M., Nadile, D., Toledo, M. E. G., Claverie, C. S., Thomson, A., Peradejordi, M., Couto, B., Favaloro, L. E., Favaloro, R., Bertolotti, A., Klein, F. Tags: In-Hospital Stroke Care Source Type: research

Preconditioned M2 microglia by oxygen-glucose deprivation promote functional recovery in ischemic rats (P1.264)
Conclusions:Intravascular administration of M2 microglia preconditioned by OGD might be a novel therapeutic strategy against ischemic stroke.Disclosure: Dr. Kanazawa has nothing to disclose. Dr. Miura has nothing to disclose. Dr. Toriyabe has nothing to disclose. Dr. Koyama has nothing to disclose. Dr. Hatakeyama has nothing to disclose. Dr. Ishikawa has nothing to disclose. Dr. Nakajima has nothing to disclose. Dr. Onodera has nothing to disclose. Dr. Nishizawa has nothing to disclose. Dr. Shimohata has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kanazawa, M., Miura, M., Toriyabe, M., Koyama, M., Hatakeyama, M., Ishikawa, M., Nakajima, T., Onodera, O., Nishizawa, M., Shimohata, T. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Brain Death Determination - a dataset analysis in Parana State Between 2013-2015 (P6.053)
Conclusions:We observed that there were marked delays between brain death suspicion and beginning the determination (~25 hrs), especially when CNS depressant drugs were used (+ 44 hrs), as well as and during BDD (~23 hrs), which can reduce the number of effective donors and viable organs available.Disclosure: Dr. Caeira has nothing to disclose. Dr. Germiniani has nothing to disclose. Dr. Rodrigues has nothing to disclose. Dr. Silvado has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Caeira, M., Germiniani, F., Rodrigues, J., Silvado, C. Tags: Neurocritical Care: Brain Death/Organ Donation Source Type: research

Ethical clinical translation of stem cell interventions for neurologic disease
The application of stem cell transplants in clinical practice has increased in frequency in recent years. Many of the stem cell transplants in neurologic diseases, including stroke, Parkinson disease, spinal cord injury, and demyelinating diseases, are unproven—they have not been tested in prospective, controlled clinical trials and have not become accepted therapies. Stem cell transplant procedures currently being carried out have therapeutic aims, but are frequently experimental and unregulated, and could potentially put patients at risk. In some cases, patients undergoing such operations are not included in a clin...
Source: Neurology - January 15, 2017 Category: Neurology Authors: Cote, D. J., Bredenoord, A. L., Smith, T. R., Ammirati, M., Brennum, J., Mendez, I., Ammar, A. S., Balak, N., Bolles, G., Esene, I. N., Mathiesen, T., Broekman, M. L. Tags: Parkinson's disease/Parkinsonism, All Ethics in Neurology/Legal issues, Malpractice, Error in medicine, Professional conduct and ethics CONTEMPORARY ISSUES Source Type: research

Teaching NeuroImages: Posterior reversible encephalopathy syndrome resulting in hydrocephalus
A woman with prior lung transplantation presented with headaches, seizure, and obtundation. Head MRI (figure) revealed obstructive hydrocephalus and hyperintensity on T2-weighted imaging in the bilateral thalami and brainstem. Management included antiepileptic medications, ventriculostomy placement, and cessation of tacrolimus for concern of atypical posterior reversible encephalopathy syndrome (PRES). Infectious and paraneoplastic etiologies were ruled out. An autoimmune process was unlikely due to immunosuppression. There was rapid clinical improvement with repeat MRI revealing resolution of hydrocephalus and T2 changes....
Source: Neurology - June 5, 2016 Category: Neurology Authors: Paolini, S., Jadhav, A. P. Tags: Hydrocephalus, Secondary headache disorders, Other cerebrovascular disease/ Stroke RESIDENT AND FELLOW SECTION Source Type: research

Glioproliferative Lesion of the Spinal Cord Derived from Intrathecal Administration of Stem Cells (P4.234)
CONCLUSIONS: Unregulated intrathecal SCT can cause devastating complications. This patient’s highly proliferative neoplasm developing from pluripotent stem cells supports the ideological shift to employ more differentiated cells in future SCT research.Disclosure: Dr. Saad has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Cagney has nothing to disclose. Dr. Chavakula has nothing to disclose. Dr. Guleria has nothing to disclose. Dr. Aizer has nothing to disclose. Dr. Ligon has nothing to disclose. Dr. Chi has nothing to disclose. Dr. Berkowitz has received royalty payments from Clinical Pathophysiology M...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Saad, M., Miller, M., Cagney, D., Chavakula, V., Guleria, I., Aizer, A., Ligon, K., Chi, J., Berkowitz, A. Tags: Neuro-oncology: Neurologic Complications of Cancer Source Type: research

Oculomotor Nerve Palsy after Herpes Zoster Opthalmicus: A Case Report and Review of Literature (P1.297)
Conclusions: HZO is manifestation of re-activation of herpes zoster with involvement of ophthalmic division of trigeminal nerve. CNIII palsy after HZO is rare, especially with associated pupillary defect. The long term prognosis is felt to be excellent with use of antiviral agents and steroids.Disclosure: Dr. Shaker has nothing to disclose. Dr. Rai has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Shaker, H., Rai, V. Tags: Herpes Virus Infections Source Type: research

Thiamine Deficiency While on Total Parenteral Nutrition Mimicking Acute Stroke: A Case Report (P3.217)
CONCLUSIONS: Thiamine deficiency mimicking stroke while on total parenteral nutrition has been rarely documented. Recognition of this syndrome is critical as prompt treatment may reverse symptoms.Disclosure: Dr. Parker has nothing to disclose. Dr. Marafie has nothing to disclose. Dr. Wolf has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Parker, A., Marafie, D., Wolf, V. Tags: Neurocritical Care: Clinical Science and Therapeutics Source Type: research

Thrombosis at the Site of Pulmonary Venous Anastomosis Following Lung Transplantation Presenting with Multiple, Bilateral, Supra- and Infra-Tentorial Ischemic Strokes in the Setting of a Known Patent Foramen Ovale (P4.355)
CONCLUSIONS: PFO-related stroke risk over time remains a controversial matter and so does its prevention by closure, as there is no current evidence-based data to justify this procedure except on anecdotal basis. LT patients may represent a subset population who could benefit from pre-operative PFO screening and closure, especially if they have a history of prior strokes.Disclosure: Dr. Yeung has nothing to disclose. Dr. Bakhos has nothing to disclose. Dr. Biller has received personal compensation in an editorial capacity for the Journal of Stroke and Cerebrovascular Diseases, Frontier in Neurology and Up-To-Date.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Yeung, S., Bakhos, M., Biller, J. Tags: Cerebrovascular Case Reports Source Type: research

Imaging of a Fatal Air Embolism from ERCP (P4.363)
CONCLUSIONS: Though most of the occurrences in relation to ERCP are portal venous air embolisms, which are absorbed spontaneously, serious and sometimes fatal complications have occurred including arterial air embolisms causing multiorgan damage including cerebral infarcts. Case history, pertinent imaging and pathological findings are discussed to bring awareness of this rare complication of ERCP and emphasize its early recognition. Disclosure: Dr. Jens has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Ibrahimi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Jens, W., Lee, A., Ibrahimi, M. Tags: Cerebrovascular Case Reports Source Type: research

Intra-Arterial Stem Cell Therapy for a Persistent Vegetative State Patient: A DTI Analysis of Recovery (P6.066)
Conclusion Assessing minor neurological improvements in this patient remains challenging but advances in neuroimaging as an evaluating tool helps to detect those changes. Future assessments and imaging will be performed to better clarify the findings mentioned above.Disclosure: Dr. Ramdas has nothing to disclose. Dr. Guada has nothing to disclose. Dr. Pafford has nothing to disclose. Dr. Haussen has nothing to disclose. Dr. Pattany has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Covidien/evV3 as a consultant and Steering Committee Member.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ramdas, K., Guada, L., Pafford, R., Haussen, D., Pattany, P., Yavagal, D. Tags: Cerebrovascular Disease: Miscellaneous Interventions Source Type: research

Susceptibility to MELAS Exacerbations in a POLG1 Mutation Carrier (P5.264)
We describe a case of a 46-year-old woman who presented with expressive aphasia, disorientation, and inappropriate laughter. She notably had a history of bilateral sensorineural hearing loss and two stroke-like episodes in her 30s characterized by left hemiparesis. Over the preceding six months, she experienced rapidly progressive vision loss, headaches, and an episode of non-convulsive status epilepticus. Incidentally, she had undergone renal transplantation nine months earlier for autosomal dominant polycystic kidney disease, and was on immunosuppressive therapy with two calcineurin inhibitors—cyclosporine and tacr...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Nadkarni, D., Restrepo, L. Tags: General Neurology: Genetics Source Type: research

Acute ischemic stroke due to Left Ventricular Noncompaction Syndrome from a novel mutation of the Lamin A/C gene (P2.254)
Conclusion: LVNC is a risk factor for cardioembolic ischemic stroke particularly in young patients that is not well known. Patients with suspected LVNC by echocardiography should undergo cardiac MRI for confirmation and genetic testing in particular for mutations in the LMNA gene. The prognosis of those with LVNC syndrome is poor; most worsen over time and need ultimately transplantation. Close follow-up is required.Disclosure: Dr. Vongveeranonchai has nothing to disclose. Dr. Mittal has nothing to disclose. Dr. Ramos Estebanez has nothing to disclose. Dr. DeGeorgia has received personal compensation for activities with OS...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Vongveeranonchai, N., Mittal, S., Ramos Estebanez, C., De Georgia, M. Tags: Cerebrovascular Disease and Interventional Neurology: Genetics and Stroke Source Type: research

Electrical Stimulation of Neural Stem Cells Improves Stroke Recovery (P1.005)
Conclusions: Our results show that electrically preconditioned NSCs enhance stroke recovery. Gene expression of the thrombospondins (a family of matricellular proteins thought to be involved with angiogenesis and inflammation) and VEGF (proteins critical to angiogenesis) were found to be modified by electrically stimulating NSCs, suggesting possible mechanisms for functional recovery.Disclosure: Dr. George has nothing to disclose. Dr. Bliss has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Hua has nothing to disclose. Dr. Sun has nothing to disclose. Dr. Steinberg has received personal compensation for activi...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Bliss, T., Mehta, S., Hua, T., Sun, G., Steinberg, G. Tags: Cerebrovascular Disease and Interventional Neurology Poster Discussion Session Source Type: research

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