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Source: JAMA

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Total 276 results found since Jan 2013.

Effect of Intensive vs Standard Treatment of Hyperglycemia on Functional Outcome in Stroke
This randomized clinical trial compares the effects of continuous intravenous vs subcutaneous sliding scale insulin for treatment of hyperglycemia during acute ischemic stroke on functional outcome in adult patients in the United States.
Source: JAMA - July 23, 2019 Category: General Medicine Source Type: research

Alteplase Inhibits Nerinetide, a Novel Stroke Drug
The investigational neuroprotectant nerinetide did not reduce disability in all patients with ischemic stroke who were treated with endovascular thrombectomy, a trial in The Lancet reported. However, patients who were not concurrently treated with alteplase had a large benefit from nerinetide.
Source: JAMA - April 28, 2020 Category: General Medicine Source Type: research

Association Between Thrombolytic Door-to-Needle Times and Ischemic Stroke Outcomes
This cohort study estimates associations between intravenous tissue plasminogen activator (tPA) door-to-needle times of less than 4.5 hours for acute ischemic stroke and 1-year mortality or readmission among Medicare beneficiaries aged 65 years or older.
Source: JAMA - June 2, 2020 Category: General Medicine Source Type: research

Long-term Outcomes After Thrombolytic Therapy for Acute Ischemic Stroke
The role of intravenous thrombolytic therapy in the management of acute ischemic stroke is well established, and faster administration of intravenous tissue plasminogen activator (tPA) has been associated with better short-term outcomes in clinical practice.
Source: JAMA - June 2, 2020 Category: General Medicine Source Type: research

Association Between New-Onset Atrial Fibrillation After Noncardiac Surgery and Subsequent Stroke and TIA
This retrospective study compared the rate of ischemic stroke or transient ischemic attack among Olmstead County, Minnesota, residents with vs without new-onset postoperative atrial fibrillation after undergoing noncardiac surgery.
Source: JAMA - September 1, 2020 Category: General Medicine Source Type: research

Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA
This Clinical Guidelines Synopsis summarizes the American Academy of Neurology ’s practice advisory update on management of patients with a patent foramen ovale who have a history of stroke or transient ischemic attack.
Source: JAMA - January 5, 2021 Category: General Medicine Source Type: research

Postoperative Atrial Fibrillation After Noncardiac Surgery and Stroke —Reply
In Reply Dr Hu and colleagues argue that the CHA2DS2-VASc score rather than the Charlson Comorbidity Index should have been used for adjustment in the outcome comparisons between the groups with and without postoperative AF in our study. Conceptually, we selected the Charlson Comorbidity Index because it captures multimorbidity more comprehensively, as opposed to the CHA2DS2-VASc score, which incorporates only a few select variables. The effect of multimorbidity would be most important in a postoperative and elderly population such as the population in our cohort. It should also be noted that the CHA2DS2-VASc score was dev...
Source: JAMA - January 12, 2021 Category: General Medicine Source Type: research

Postoperative Atrial Fibrillation After Noncardiac Surgery and Stroke
To the Editor Dr Siontis and colleagues reported that among patients undergoing noncardiac surgery, long-term risks of stroke or transient ischemic attack (TIA), subsequent atrial fibrillation (AF), and all-cause death were higher in patients with new-onset postoperative AF than in those without postoperative AF. The differences were maintained after adjustment for age and Charlson Comorbidity Index. However, factors selected for adjustment might bias their findings.
Source: JAMA - January 12, 2021 Category: General Medicine Source Type: research

Effect of Endovascular Treatment With vs Without IV Alteplase on Functional Independence After Acute Ischemic Stroke
This noninferiority trial compares the effects of endovascular treatment with vs without intravenous alteplase on 90-day functional independence among patients with acute ischemic stroke.
Source: JAMA - January 19, 2021 Category: General Medicine Source Type: research

Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis in Acute Ischemic Stroke
This noninferiority trial compares the effects of mechanical thrombectomy with vs without intravenous thrombolysis (0.6-mg/kg alteplase) on 90-day disability among patients with acute large vessel occlusive ischemic stroke.
Source: JAMA - January 19, 2021 Category: General Medicine Source Type: research

Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke
The 2 reperfusion therapies of proven benefit for acute ischemic stroke, mechanical endovascular thrombectomy (EVT) and pharmacologic intravenous thrombolysis (IVT), have complementary advantages. EVT, which involves mechanical debulking, works well for accessible sizeable thrombi that occlude large cerebral vessels and are resistant to rapid thrombolytic dissolution. IVT, which involves chemical dissolution, works well for smaller thrombi that occlude medium and small cerebral vessels inaccessible or poorly accessible to endovascular technology. An open, important question has been whether the modest efficacy of IVT for l...
Source: JAMA - January 19, 2021 Category: General Medicine Source Type: research

Incidence of Transient Ischemic Attack and Association With Long-term Risk of Stroke
This cohort study uses Framingham Heart Study (FHS) data to assess population-based incidence of transient ischemic attack (TIA), and the timing and long-term trends of stroke risk after TIA, among participants in the FHS Original, Offspring, and Third Generation cohorts from 1948 to 2017.
Source: JAMA - January 26, 2021 Category: General Medicine Source Type: research

Diagnosis and Management of Transient Ischemic Attack and Acute Ischemic Stroke
This narrative review provides an update on management of transient ischemic attack (TIA) and acute ischemic stroke, emphasizing advances in use of dual antiplatelet therapy and fibrinolysis vs mechanical thrombectomy for secondary and tertiary prevention.
Source: JAMA - March 16, 2021 Category: General Medicine Source Type: research

Functional Outcomes Among Patients With Acute Ischemic Stroke After Mechanical Thrombectomy With or Without Intravenous Thrombolysis
To the Editor In their randomized clinical trial, Dr Suzuki and colleagues reported that mechanical thrombectomy alone failed to demonstrate noninferiority compared with combined intravenous thrombolysis and mechanical thrombectomy with regard to favorable functional outcome at 90 days in patients with acute ischemic stroke. We have some concerns about this study.
Source: JAMA - May 18, 2021 Category: General Medicine Source Type: research

Preliminary Investigation of In situ Thrombus Within Patent Foramen Ovale in Patients With and Without Stroke
This study uses high-resolution optical coherence tomography to investigate whether patent foramen ovale could be the site of thrombus formation in patients with or without stroke.
Source: JAMA - May 25, 2021 Category: General Medicine Source Type: research