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Prediction of short-term atrial fibrillation risk using primary care electronic health records
Conclusions FIND-AF, a machine learning algorithm applicable at scale in routinely collected primary care data, identifies people at higher risk of short-term AF.
Source: Heart - June 26, 2023 Category: Cardiology Authors: Nadarajah, R., Wu, J., Hogg, D., Raveendra, K., Nakao, Y. M., Nakao, K., Arbel, R., Haim, M., Zahger, D., Parry, J., Bates, C., Cowan, C., Gale, C. P. Tags: Open access, Editor's choice Arrhythmias and sudden death Source Type: research

Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer
Conclusions Cancer history is linked to increased risk of incident CVDs and adverse cardiac remodelling independent of shared vascular risk factors.
Source: Heart - June 14, 2023 Category: Cardiology Authors: Raisi-Estabragh, Z., Cooper, J., McCracken, C., Crosbie, E. J., Walter, F. M., Manisty, C. H., Robson, J., Mamas, M. A., Harvey, N. C., Neubauer, S., Petersen, S. E. Tags: Open access, Editor's choice, Press releases Cardiac risk factors and prevention Source Type: research

Heartbeat: hospitalisation for COVID-19 is associated with an increased risk of subsequent adverse cardiovascular events
In order to assess whether previous COVID-19 infection might be associated with a higher risk of subsequent adverse cardiovascular disease (CVD) events, Raisi-Estabragh and colleagues1 analysed incident CVD events in 17 871 UK Biobank cases with prospective follow-up from March 2020 to March 2021. Hospitalisation for COVID-19 was associated with an increased risk of several adverse CVD events, including myocardial infarction, stroke, heart failure, atrial fibrillation, venous thromboembolism and mortality (figure 1). Risk was highest in the first 30 days after infection, but remained higher than matched controls over an av...
Source: Heart - December 22, 2022 Category: Cardiology Authors: Otto, C. M. Tags: COVID-19 Highlights from this issue Source Type: research

Not to be sneezed at: cardiovascular disease after COVID-19 infection
COVID-19 has changed our way of life since it was first identified in December of 2019. While our understanding of the manifestations and outcomes of the immediate acute illness has improved, we are still learning about the medium to long-term impact of this diagnosis on patients’ health. For some time, it has been suggested that COVID-19 may be associated with incident cardiovascular events such as venous thromboembolism, stroke and myocardial infarction.1 However, the absolute risk of these events and whether an excess risk is present are challenging to determine without a contemporary reference population. This is...
Source: Heart - December 22, 2022 Category: Cardiology Authors: Bularga, A., Newby, D. E., Chapman, A. R. Tags: Press releases, COVID-19 Editorials Source Type: research

Cardiovascular disease and mortality sequelae of COVID-19 in the UK Biobank
Conclusions Individuals hospitalised with COVID-19 have increased risk of incident cardiovascular events across a range of disease and mortality outcomes. The risk of most events is highest in the early postinfection period. Individuals not requiring hospitalisation have increased risk of VTE, but not of other cardiovascular-specific outcomes.
Source: Heart - December 22, 2022 Category: Cardiology Authors: Raisi-Estabragh, Z., Cooper, J., Salih, A., Raman, B., Lee, A. M., Neubauer, S., Harvey, N. C., Petersen, S. E. Tags: Open access, Editor's choice, Press releases, COVID-19 Cardiac risk factors and prevention Source Type: research

Atrial fibrillation following transcatheter atrial septal defect closure: a systematic review and meta-analysis
Conclusions The incidence of new-onset AFi/AFl is relatively low following transcatheter closure of secundum ASDs. The rate of de novo AFi/AFl, however, was significantly higher in elderly patients. Shorter follow-up time was associated with a higher reported incidence of AFi/AFl.
Source: Heart - July 13, 2022 Category: Cardiology Authors: Himelfarb, J. D., Shulman, H., Olesovsky, C. J., Rumman, R. K., Oliva, L., Friedland, J., Farrell, A., Huszti, E., Horlick, E., Abrahamyan, L. Tags: Congenital heart disease Source Type: research

Management and outcomes of patients with left atrial appendage thrombus prior to percutaneous closure
Conclusion In the presence of LAA thrombus, IAT was the initial management strategy in half of our cohort, with initial thrombus resolution in 60% of these, but with a relatively high bleeding rate (~10%). Direct LAAC was feasible, with high procedural success and absence of periprocedural embolic complications. However, a high rate of device-related thrombosis was detected during follow-up.
Source: Heart - June 24, 2022 Category: Cardiology Authors: Marroquin, L., Tirado-Conte, G., Pracon, R., Streb, W., Gutierrez, H., Boccuzzi, G., Arzamendi-Aizpurua, D., Cruz-Gonzalez, I., Ruiz-Nodar, J. M., Kim, J.-S., Freixa, X., Lopez-Minguez, J. R., De Backer, O., Ruiz-Salmeron, R., Dominguez, A., McInerney, A. Tags: Open access Arrhythmias and sudden death Source Type: research

Prediction of incident atrial fibrillation in community-based electronic health records: a systematic review with meta-analysis
Conclusions Models externally validated for prediction of incident AF in community-based EHR demonstrate moderate predictive ability and high risk of bias. Novel methods may provide stronger discriminative performance. Systematic review registration PROSPERO CRD42021245093.
Source: Heart - June 10, 2022 Category: Cardiology Authors: Nadarajah, R., Alsaeed, E., Hurdus, B., Aktaa, S., Hogg, D., Bates, M. G. D., Cowan, C., Wu, J., Gale, C. P. Tags: Open access Arrhythmias and sudden death Source Type: research

Single direct oral anticoagulant therapy in stable patients with atrial fibrillation beyond 1 year after coronary stent implantation
Conclusions DOAC monotherapy showed similar efficacy in preventing ischaemic events and was associated with lower major bleeding events compared with combination therapy in patients with AF beyond 1 year after coronary stent implantation.
Source: Heart - January 28, 2022 Category: Cardiology Authors: Choi, Y., Lee, Y., Kim, S.-H., Kim, S., Kim, J. Y., Kim, T.-S., Hwang, Y., Kim, J.-H., Jang, S.-W., Lee, M. Y., Oh, Y.-S. Tags: Coronary artery disease Source Type: research

Risk of left atrial appendage thrombus and stroke in patients with atrial fibrillation and mitral regurgitation
Conclusions Among patients with NVAF, the presence or severity of MR was not associated with a decreased risk of LAAT or stroke.
Source: Heart - December 10, 2021 Category: Cardiology Authors: Melduni, R., Nkomo, V. T., Wysokinski, W., Gersh, B. J., Deshmukh, A., Padang, R., Greene, E. L., Oh, J. K., Lee, H.-C. Tags: Arrhythmias and sudden death Source Type: research

Pre-procedural dual antiplatelet therapy in patients undergoing transcatheter aortic valve implantation increases risk of bleeding
Conclusions The current study demonstrated that DAPT before TF-TAVI increased the risk of bleeding compared with single or no antiplatelet therapy. Lower intensity antiplatelet therapy was not associated with thrombotic events. In modern practice, it might be reasonable to perform TAVI using single or no pre-procedural antiplatelet therapy with an expectation of no increase of adverse events. Trial registration number UMIN-ID; 000020423; Results.
Source: Heart - February 15, 2017 Category: Cardiology Authors: Hioki, H., Watanabe, Y., Kozuma, K., Nara, Y., Kawashima, H., Kataoka, A., Yamamoto, M., Takagi, K., Araki, M., Tada, N., Shirai, S., Yamanaka, F., Hayashida, K., And on behalf of OCEAN-TAVI investigators Tags: Valvular heart disease Source Type: research

Heartbeat: Left atrial appendage occlusion for stroke prevention
Stroke prevention is the primary goal of therapy in patients with atrial fibrillation (AF).1 Heart has published numerous papers on early AF detection,2 approaches for restoring normal sinus rhythm, risk scores for determining which AF patients benefit most from anti-thrombotic therapy, and transcatheter occlusion of the left atrial appendage (LAA) to prevent thrombus formation.3–6 Early studies of LAA occlusion compared this procedure to vitamin K antagonist (VKA) therapy for stroke prevention. Now, direct oral anticoagulants (DOACs) have replaced VKA therapy in many AF patients due to an improved risk/benefit profi...
Source: Heart - January 4, 2017 Category: Cardiology Authors: Otto, C. M. Tags: Heartbeat Source Type: research

Left atrial appendage occlusion in high-risk patients with non-valvular atrial fibrillation
Conclusions Our data suggest LAA occlusion in high-risk patients with NVAF not suitable for OACs is feasible and associated with low complication rates as well as low rates of stroke and major bleeding at long-term follow-up.
Source: Heart - November 24, 2016 Category: Cardiology Authors: Berti, S., Pastormerlo, L. E., Rezzaghi, M., Trianni, G., Paradossi, U., Cerone, E., Ravani, M., De Caterina, A. R., Rizza, A., Palmieri, C. Tags: Drugs: cardiovascular system, Echocardiography, Clinical diagnostic tests Cardiac risk factors and prevention Source Type: research

Antithrombotic drug use: scientific breakthroughs, biological limits and physician behaviour
During the past 25 years, there has been a dramatic surge in the use of antithrombotic drugs as documented in the Heart paper by Adelborg et al.1 The authors derived their findings from the Danish drug utilisation database, which is unique in its comprehensiveness and ability to capture over-the-counter aspirin. The increased prescription of antithrombotic drugs is fuelled by a better understanding of disease and risk, population growth, ageing societies, improved methods of detection, and rising global rates of obesity, a recognised risk factor for atrial fibrillation (AF), venous thromboembolic (VTE) disease, and ca...
Source: Heart - November 10, 2016 Category: Cardiology Authors: Hylek, E. M. Tags: Drugs: cardiovascular system, Venous thromboembolism, Epidemiology Editorials Source Type: research

Stroke and death in elderly patients with atrial fibrillation in Japan compared with the United Kingdom
Conclusions Elderly (age ≥75 years) patients with AF in both Japan and the UK are at similarly high risk of stroke and death, with OAC still underused in both populations. Ethnicity was not independently associated with the risk of stroke, regardless of OAC use or non-use.
Source: Heart - November 10, 2016 Category: Cardiology Authors: Senoo, K., An, Y., Ogawa, H., Lane, D. A., Wolff, A., Shantsila, E., Akao, M., Lip, G. Y. H. Tags: Drugs: cardiovascular system, Heart failure, Hypertension, Epidemiology, Diabetes, Metabolic disorders Health care delivery, economics and global health care Source Type: research

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