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Short-term effects of air pollution on a range of cardiovascular events in England and Wales: case-crossover analysis of the MINAP database, hospital admissions and mortality
Conclusions This study found no clear evidence for pollution effects on STEMIs and stroke, which ultimately represent thrombogenic processes, though it did for pulmonary embolism. The strongest associations with air pollution were observed with selected non-MI outcomes.
Source: Heart - June 21, 2014 Category: Cardiology Authors: Milojevic, A., Wilkinson, P., Armstrong, B., Bhaskaran, K., Smeeth, L., Hajat, S. Tags: Open access, Drugs: cardiovascular system, Acute coronary syndromes, Venous thromboembolism, Epidemiology Cardiac risk factors and prevention Source Type: research

Cardiovascular highlights from non-cardiology journals
Estrogen formulations have differing cardiovascular risk profile Ever since the publication of the Women's Health Initiative randomized trial that demonstrated clinical harm associated with use of conjugated equine estrogens, providers have been left in a challenging position in balancing the risk of these therapies against their benefit in treatment of menopausal symptoms. In the present study, the authors examined cardiac safety of oral conjugated equine estrogen vs. oral estradiol in a population-based case control study of post-menopausal women. Cases of venous thrombosis (n=68), myocardial infarction (n=67) or ischemi...
Source: Heart - May 19, 2014 Category: Cardiology Authors: Bradley, S. M. Tags: Journal scan Source Type: research

Atrial fibrillation and thromboembolism in patients with hypertrophic cardiomyopathy: systematic review
Conclusions AF is common in HCM and associated with high thromboembolic risk. LA dimension and age are independently associated with AF but the literature is insufficient to create robust clinical tools to predict AF or thromboembolism. Most data suggest that AF patients should be anticoagulated.
Source: Heart - February 19, 2014 Category: Cardiology Authors: Guttmann, O. P., Rahman, M. S., O'Mahony, C., Anastasakis, A., Elliott, P. M. Tags: Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Epidemiology Heart failure and cardiomyopathies Source Type: research

Alcohol intake and prognosis of atrial fibrillation
Conclusions High alcohol intake predicts thromboembolism or death, even after adjustment for established clinical risk factors, and may help identify high risk AF patients who could be targeted for stroke and cardiovascular prevention strategies.
Source: Heart - July 5, 2013 Category: Cardiology Authors: Overvad, T. F., Rasmussen, L. H., Skjoth, F., Overvad, K., Albertsen, I. E., Lane, D. A., Lip, G. Y. H., Larsen, T. B. Tags: Editor's choice, Drugs: cardiovascular system, Epidemiology Heart rhythm disorders Source Type: research

Rivaroxaban and other novel anticoagulants for stroke prevention in atrial fibrillation: time to embrace the future
Atrial fibrillation (AF) is now said to be at epidemic proportions.1 Although symptoms and heart failure are two of the main reasons that patients with AF suffer from reduced quality of life, thromboembolic complications, particularly stroke, remain the major determinant of significant morbidity and mortality.2 Importantly, the risk of thromboembolism (TE) is completely irrespective of symptoms, and hence the sad fact that people continue to present with catastrophic stroke in AF with no prior history of its detection.3 Appropriate anticoagulation is imperative to reduce the TE/stroke risk. Numerous large scale studies hav...
Source: Heart - February 18, 2013 Category: Cardiology Authors: Rajappan, K. Tags: Drugs: cardiovascular system, Epidemiology Editorials Source Type: research

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