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Endovascular Treatment After Stroke Due to Large Vessel Occlusion for Patients Presenting Very Late
This case-control study examines the prevalence of salvageable tissues 16 hours or more from the time the patient was last known well after ischemic stroke due to emergent large vessel occlusion and investigates the effectiveness of endovascular treatment in delayed large vessel occlusion.
Source: JAMA Neurology - August 10, 2020 Category: Neurology Source Type: research

Antihypertensive Medication Use Among Individuals With a History of Stroke and Hypertension, 2005 to 2016
This cross-sectional study investigates the adequacy of blood pressure control among stroke survivors and antihypertensive treatment trends using National Health and Nutrition Examination Survey data.
Source: JAMA Neurology - July 27, 2020 Category: Neurology Source Type: research

Characteristics of Recurrent Ischemic Stroke After ESUS
This secondary analysis of a randomized clinical trial assesses the subtype of recurrent ischemic stroke after embolic stroke of underdetermined source, the interaction with treatment assignment, and the consistency of cerebral location of the qualifying and recurrent strokes in the study population of the NAVIGATE-ESUS trial.
Source: JAMA Neurology - July 6, 2020 Category: Neurology Source Type: research

Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza
This cohort study compares the rate of ischemic stroke among patients with COVID-19 vs patients with influenza in 2 hospitals in New York City, New York.
Source: JAMA Neurology - July 2, 2020 Category: Neurology Source Type: research

Migraines During Pregnancy and the Risk of Maternal Stroke
This cohort study examines the extent to which hypertensive disorders mediate the association between migraines and maternal stroke.
Source: JAMA Neurology - June 1, 2020 Category: Neurology Source Type: research

Prognosis of Asymptomatic Intracranial Stenosis in Patients With Transient Ischemic Attack and Minor Stroke
This cohort study examines the age-specific prevalence and prognosis of asymptomatic intracranial stenosis in British patients with transient ischemic attack and minor stroke.
Source: JAMA Neurology - May 26, 2020 Category: Neurology Source Type: research

Care Delivery and Outcomes for Acute Stroke and Transient Ischemic Attacks in Rural and Urban Medicare Patients
This cohort study describes trends among rural and urban patients with acute ischemic stroke or transient ischemic attack in the type of health care centers to which patients were admitted, what care was provided, and patient outcomes.
Source: JAMA Neurology - May 4, 2020 Category: Neurology Source Type: research

Importance of the Intention-to-Treat Principle
To the Editor The recent study by Goyal et al represents the third largest cohort study on patients with large vessel occlusions (LVOs) who present with mild deficits (National Institutes of Health Stroke Scale score, 0-5) and, to our knowledge, the largest meta-analysis regarding this topic. This highlights the growing interest on how to optimally treat such patients.
Source: JAMA Neurology - May 4, 2020 Category: Neurology Source Type: research

Magnetic Resonance Imaging for Acute Minor Neurological Symptoms
To the Editor An observational study of magnetic resonance imaging (MRI) in acute minor neurological symptoms revealed imaging evidence for acute infarction in 13.5% and revision of clinical diagnosis in 30%. This “implies a considerable percentage of patients’ negative MRI findings resulted in a different diagnosis, likely that a presumed stroke did not exist.” This conclusion is misleading in 2 respects.
Source: JAMA Neurology - April 20, 2020 Category: Neurology Source Type: research

Implementation of a Prehospital Stroke Triage System Using Symptom Severity and Teleconsultation
This cohort study examines a system for prehospital triage for Swedish patients with suspected acute stroke.
Source: JAMA Neurology - April 6, 2020 Category: Neurology Source Type: research

Endovascular Treatment for Acute Basilar Artery Occlusion via a Nationwide Prospective Registry
This nonrandomized cohort study evaluates the association between endovascular treatment and the clinical outcomes of patients with stroke and acute basilar artery occlusion, compared with patients who received standard medical treatment only.
Source: JAMA Neurology - February 20, 2020 Category: Neurology Source Type: research

Distributional Validity and Prognostic Power of the NIHSS in US Administrative Claims Data
This cross-sectional study analyzes the distributional, convergent, and predictive validity of National Institutes of Health Stroke Scale (NIHSS) values in the National Inpatient Sample.
Source: JAMA Neurology - February 17, 2020 Category: Neurology Source Type: research

Blood Pressure Thresholds in Endovascular Therapy for Acute Ischemic Stroke
This cohort study investigates whether procedural blood pressure parameters, including specific blood pressure thresholds, are associated with neurological outcomes after endovascular therapy.
Source: JAMA Neurology - January 27, 2020 Category: Neurology Source Type: research

Intra-arterial Urokinase After Incomplete Mechanical Thrombectomy
Complete and rapid revascularization can dramatically reduce disability after large-vessel occlusion (LVO) acute ischemic stroke (AIS). With modern mechanical thrombectomy (MT), we now have a safe and effective method to recanalize occluded cerebral vessels, and in this issue of JAMA Neurology, Kaesmacher et al move the field 1 step closer to achieving the goal of complete revascularization. Cohort studies have demonstrated that even among patients who achieve substantial reperfusion, defined as a Thrombolysis in Cerebral Infarction grade of 2b or greater, those who achieve the highest grades of reperfusion have quantifiab...
Source: JAMA Neurology - December 9, 2019 Category: Neurology Source Type: research

The Hazard of Negative (Not Neutral) Trials on Treatment of Acute Stroke
This narrative review summarizes randomized clinical trials with negative (vs neutral) outcomes to study why previous acute stroke interventions appeared to cause harm.
Source: JAMA Neurology - December 2, 2019 Category: Neurology Source Type: research

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