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Incremental Prognostic Significance of the Elevated Levels of Pentraxin 3 in Patients With Heart Failure With Normal Left Ventricular Ejection Fraction Heart Failure
Conclusions High plasma PTX3 levels, but not other inflammatory markers, are correlated with future cardiovascular events in patients with HFNEF. PTX3 may be a useful biomarker for assessment of risk stratification in HFNEF. Clinical Trial Registration URL: http://www.umin.ac.jp; Unique identifier: UMIN000002170.
Source: JAHA:Journal of the American Heart Association - July 10, 2014 Category: Cardiology Authors: Matsubara, J., Sugiyama, S., Nozaki, T., Akiyama, E., Matsuzawa, Y., Kurokawa, H., Maeda, H., Fujisue, K., Sugamura, K., Yamamoto, E., Matsui, K., Jinnouchi, H., Ogawa, H. Tags: Heart Failure Source Type: research

Clinical Prediction Model Suitable for Assessing Hospital Quality for Patients Undergoing Carotid Endarterectomy Stroke
Conclusions The NCDR CEA score, comprising 7 clinical variables, predicts in-hospital stroke or death after CEA. This model can be used to estimate hospital risk-adjusted outcomes for CEA and to assist with the assessment of hospital quality.
Source: JAHA:Journal of the American Heart Association - June 17, 2014 Category: Cardiology Authors: Wimmer, N. J., Spertus, J. A., Kennedy, K. F., Anderson, H. V., Curtis, J. P., Weintraub, W. S., Singh, M., Rumsfeld, J. S., Masoudi, F. A., Yeh, R. W. Tags: Stroke Source Type: research

Atrial Fibrillation, Stroke, and Anticoagulation in Medicare Beneficiaries: Trends by Age, Sex, and Race, 1992-2010 Stroke
Conclusions Ischemic stroke rates among Medicare AF patients decreased significantly in all demographic subpopulations from 1992–2010, coincident with increasing warfarin use. Ischemic stroke rates remained higher and warfarin use rates remained lower for women and blacks with AF, groups whose baseline CHADS scores were higher.
Source: JAHA:Journal of the American Heart Association - June 3, 2014 Category: Cardiology Authors: Shroff, G. R., Solid, C. A., Herzog, C. A. Tags: Stroke Source Type: research

Long-term Cardiovascular Risks Associated With an Elevated Heart Rate: The Framingham Heart Study Epidemiology
Conclusions Individuals with a higher heart rate are at elevated long-term risk for cardiovascular events, in particular, heart failure, and all-cause death. On the other hand, a higher heart rate is associated with a lower risk of future permanent pacemaker implantation.
Source: JAHA:Journal of the American Heart Association - May 8, 2014 Category: Cardiology Authors: Ho, J. E., Larson, M. G., Ghorbani, A., Cheng, S., Coglianese, E. E., Vasan, R. S., Wang, T. J. Tags: Epidemiology Source Type: research

Adherence to Guideline-Recommended Therapy Is Associated With Decreased Major Adverse Cardiovascular Events and Major Adverse Limb Events Among Patients With Peripheral Arterial Disease Heart Failure
Conclusions In patients with claudication or CLI, combination treatment with four guideline-recommended therapies is associated with significant reductions in MACE, MALE, and mortality.
Source: JAHA:Journal of the American Heart Association - April 10, 2014 Category: Cardiology Authors: Armstrong, E. J., Chen, D. C., Westin, G. G., Singh, S., McCoach, C. E., Bang, H., Yeo, K.-K., Anderson, D., Amsterdam, E. A., Laird, J. R. Tags: Heart Failure Source Type: research

A Randomized Pilot Study of Aortic Waveform Guided Therapy in Chronic Heart Failure Heart Failure
Conclusions Maximization of goal-directed medical therapy in heart failure patients may enhance afterload reduction and lead to reverse remodeling, while additional medicine titration based upon aortic pressure data improves exercise capacity in patients with heart failure.
Source: JAHA:Journal of the American Heart Association - March 20, 2014 Category: Cardiology Authors: Borlaug, B. A., Olson, T. P., Abdelmoneim Mohamed, S., Melenovsky, V., Sorrell, V. L., Noonan, K., Lin, G., Redfield, M. M. Tags: Heart Failure Source Type: research

Long-term Cardiovascular Outcomes in Patients With Chronic Kidney Disease Undergoing Coronary Artery Bypass Graft Surgery for Acute Coronary Syndromes Cardiovascular Surgery
Conclusions Severe, but not moderate, renal dysfunction was independently associated with an increased risk of long-term cardiovascular events and death in patients undergoing CABG for acute coronary syndromes.
Source: JAHA:Journal of the American Heart Association - March 4, 2014 Category: Cardiology Authors: Holzmann, M., Jernberg, T., Szummer, K., Sartipy, U. Tags: Cardiovascular Surgery Source Type: research

Cardiovascular and Mortality Risk of Apparent Resistant Hypertension in Women With Suspected Myocardial Ischemia: A Report From the NHLBI-Sponsored WISE Study Hypertension
Conclusions In this cohort of women with evidence of ischemia, aTRH was associated with a profoundly increased long-term risk of major adverse events, including death, that emerged early during follow-up.
Source: JAHA:Journal of the American Heart Association - February 28, 2014 Category: Cardiology Authors: Smith, S. M., Huo, T., Delia Johnson, B., Bittner, V., Kelsey, S. F., Vido Thompson, D., Noel Bairey Merz, C., Pepine, C. J., Cooper-DeHoff, R. M. Tags: Hypertension Source Type: research

Peripheral Endothelial Function and Cardiovascular Events in High-Risk Patients Vascular Medicine
Conclusions Advanced endothelial dysfunction significantly correlated with near future cardiovascular events in high-risk patients. This physiological vascular measurement improved risk discrimination when added to the FRS, BNP, and SYNTAXsc. Clinical Trial Registration URL: clinicaltrials.gov (http://www.clinicaltrials.gov). Unique identifier: NCT00737945.
Source: JAHA:Journal of the American Heart Association - November 25, 2013 Category: Cardiology Authors: Matsuzawa, Y., Sugiyama, S., Sumida, H., Sugamura, K., Nozaki, T., Ohba, K., Matsubara, J., Kurokawa, H., Fujisue, K., Konishi, M., Akiyama, E., Suzuki, H., Nagayoshi, Y., Yamamuro, M., Sakamoto, K., Iwashita, S., Jinnouchi, H., Taguri, M., Morita, S., Ma Tags: Vascular Medicine Source Type: research

Early Adoption of Dabigatran and Its Dosing in US Patients With Atrial Fibrillation: Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation Health Services and Outcomes Research
Conclusions Patients receiving dabigatran were younger and at a lower risk of stroke and bleeding. Patients appeared to drive switching from warfarin, whereas clinical characteristics influenced de novo start of dabigatran. These data suggest cautious early uptake of dabigatran, and more careful attention to dosing adjustments is warranted. Clinical Trial Registration URL: Clinicaltrials.gov. Unique identifier: NCT01165710.
Source: JAHA:Journal of the American Heart Association - November 25, 2013 Category: Cardiology Authors: Steinberg, B. A., Holmes, D. N., Piccini, J. P., Ansell, J., Chang, P., Fonarow, G. C., Gersh, B., Mahaffey, K. W., Kowey, P. R., Ezekowitz, M. D., Singer, D. E., Thomas, L., Peterson, E. D., Hylek, E. M., The Outcomes Registry for Better Informed Treatme Tags: Health Services and Outcomes Research Source Type: research

Hostility, Health Behaviors, and Risk of Recurrent Events in Patients With Stable Coronary Heart Disease: Findings From the Heart and Soul Study Epidemiology
Conclusions Hostility was a significant predictor of secondary events in this sample of outpatients with baseline stable CHD. Much of this association was moderated by poor health behaviors, specifically physical inactivity and smoking.
Source: JAHA:Journal of the American Heart Association - September 30, 2013 Category: Cardiology Authors: Wong, J. M., Na, B., Regan, M. C., Whooley, M. A. Tags: Epidemiology Source Type: research

Atrial Fibrillation Patterns and Risks of Subsequent Stroke, Heart Failure, or Death in the Community Arrhythmia and Electrophysiology
Conclusions In our community-based AF sample, only 10% had AF without early-term (2-year) recurrence. Compared with individuals without 2-year AF recurrences, the 10-year prognosis was worse for individuals with either sustained or recurrent AF. Our proposed AF classification algorithm may be applicable in longitudinal datas ets.
Source: JAHA:Journal of the American Heart Association - September 3, 2013 Category: Cardiology Authors: Lubitz, S. A., Moser, C., Sullivan, L., Rienstra, M., Fontes, J. D., Villalon, M. L., Pai, M., McManus, D. D., Schnabel, R. B., Magnani, J. W., Yin, X., Levy, D., Pencina, M. J., Larson, M. G., Ellinor, P. T., Benjamin, E. J. Tags: Arrhythmia and Electrophysiology Source Type: research

Simple Integer Risk Score to Determine Prognosis of Patients With Hypertension and Chronic Stable Coronary Artery Disease Coronary Heart Disease
Conclusion Readily available clinical variables can rapidly stratify patients with hypertension and chronic stable CAD into useful risk categories.
Source: JAHA:Journal of the American Heart Association - August 15, 2013 Category: Cardiology Authors: Bavry, A. A., Kumbhani, D. J., Gong, Y., Handberg, E. M., Cooper-DeHoff, R. M., Pepine, C. J. Tags: Coronary Heart Disease Source Type: research

A New Risk Scheme to Predict Ischemic Stroke and Other Thromboembolism in Atrial Fibrillation: The ATRIA Study Stroke Risk Score Arrhythmia and Electrophysiology
Conclusions The ATRIA stroke risk score performed better than existing risk scores, was validated successfully, and showed improvement in predicting severe events, which is of greatest concern. The ATRIA score should improve the antithrombotic decision for patients with AF and should provide a secure foundation for the addition of biomarkers in future prognostic models.
Source: JAHA:Journal of the American Heart Association - June 19, 2013 Category: Cardiology Authors: Singer, D. E., Chang, Y., Borowsky, L. H., Fang, M. C., Pomernacki, N. K., Udaltsova, N., Reynolds, K., Go, A. S. Tags: Arrhythmia and Electrophysiology Source Type: research

Sex-Specific Differences in the Predictive Value of Cholesterol Homeostasis Markers and 10-Year Cardiovascular Disease Event Rate in Framingham Offspring Study Participants Coronary Heart Disease
Conclusions These data suggest significant sex differences in the 10-year prognostic value of cholesterol synthesis markers and HCHD, specifically coronary death and incidence of myocardial infarction. Clinical Trial Registration URL:http://ClinicalTrials.gov. Unique identifier: NCT00074464.
Source: JAHA:Journal of the American Heart Association - February 19, 2013 Category: Cardiology Authors: Matthan, N. R., Zhu, L., Pencina, M., D'Agostino, R. B., Schaefer, E. J., Lichtenstein, A. H. Tags: Coronary Heart Disease Source Type: research

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