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Specialty: Cardiology
Source: European Heart Journal
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Total 332 results found since Jan 2013.
Ticagrelor, but not clopidogrel active metabolite, displays antithrombotic properties in the left atrial endocardium
Conclusion</div>Ticagrelor, but not CAM, reduces expression and activity of TF and PAI-1 in LAA endocardial cells isolated from patients with AF, indicating possible local antithrombotic effects. Such pleiotropic properties of ticagrelor may contribute to a reduction in thromboembolic complications in patients with AF.</span>
Source: European Heart Journal - January 8, 2017 Category: Cardiology Source Type: research
A novel risk prediction score in atrial fibrillation for a net clinical outcome from the ENGAGE AF-TIMI 48 randomized clinical trial
Conclusion</div>In VKA naive patients with AF, the TIMI-AF score can assist in the prediction of a poor composite outcome and guide selection of anticoagulant therapy by identifying a differential clinical benefit with a NOAC or VKA.</span>
Source: European Heart Journal - January 7, 2017 Category: Cardiology Source Type: research
Brockenbrough-Braunwald-Morrow sign
<span class="paragraphSection">A 56-year-old man presented with mild exertional dyspnea for one year. Cardiac auscultation noted a grade 3 ejection murmur at lower left sternal border which became louder and shorter (early systolic) after a premature contraction (<span style="font-style:italic;">Panel A</span>, arrow). 2D echocardiogram revealed a marked asymmetric septal hypertrophy (<span style="font-style:italic;">Panel B</span>), and a systolic anterior motion (SAM) of mitral valve and midsystolic closure (MSC) of aortic valve were detected in the postextrasystolic beat (<span style="fo...
Source: European Heart Journal - October 24, 2016 Category: Cardiology Source Type: research
Radial versus femoral access in patients with acute coronary syndromes with or without ST-segment elevation
Conclusion</div>Radial as compared with femoral access provided consistent benefit across the whole spectrum of patients with ACS, without evidence that type of presenting syndrome affected the results of the random access allocation.</span>
Source: European Heart Journal - February 28, 2017 Category: Cardiology Source Type: research
Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors
Conclusion</div>Prognostic models for cardiovascular events and bleeding using population-based EHRs may help to personalise decisions for prolonged DAPT 1-year following acute MI.</span>
Source: European Heart Journal - February 27, 2017 Category: Cardiology Source Type: research
Subclinical atrial fibrillation in need of more assertive evidence
<span class="paragraphSection"><strong>This editorial refers to ‘Duration of device-detected subclinical atrial fibrillation and occurrence of stroke in ASSERT’†<sup> †</sup>, by I.C. Van Gelder<span style="font-style:italic;">et al.</span>, on page<strong><a href="article.aspx?volume=&page=">1339<span></span></a></strong>.</strong></span>
Source: European Heart Journal - March 31, 2017 Category: Cardiology Source Type: research
Long-term symptom improvement and patient satisfaction following catheter ablation of supraventricular tachycardia: insights from the German ablation registry
Conclusion</div>Ablation therapy for SVT is a safe procedure bringing symptomatic improvement and satisfaction to three quarters of patients after 1 year. Even in patients with arrhythmia recurrence, a high satisfaction level and adherence to the ablating institution could be documented. Strikingly high mortality and stroke rates in follow-up were observed in AFL patients, who apparently need consistent long-term anticoagulation and more medical attention.</span>
Source: European Heart Journal - March 17, 2017 Category: Cardiology Source Type: research
Female gender as a risk factor for stroke associated with atrial fibrillation
This editorial refers to ‘Revisiting sex differences in outcomes in non-valvular atrial fibrillation: a population-based cohort study’†, by C. Renouxet al., on page1473.
Source: European Heart Journal - March 27, 2017 Category: Cardiology Source Type: research
Modern prevention: genetic testing, vascular imaging, machine learning, and drug safety
Traditionally, prevention has been divided into primary and secondary prevention. While the former focused on individuals considered healthy, the latter was designed to avoid future events in those who already had coronary artery disease, myocardial infarction, or stroke.1 However, this distinction is no longer useful, as many asymptomatic individuals do have atherosclerotic lesions such as plaques and calcifications upon modern imaging, and not all subjects with suspected symptoms have atherosclerotic vascular disease.2 –4 This Focus Issue on Prevention addresses these important issues. In a firstCurrent Opinion entitle...
Source: European Heart Journal - June 13, 2017 Category: Cardiology Source Type: research
NSAIDs and cardiac arrest Non-steroidal anti-inflammatory drug use is associated with increased risk of Out-of-hospital Cardiac Arrest: A nationwide Case-Time-Control study
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs worldwide. However, during the last 10 years, accumulating evidence of an increased cardiovascular risk associated with use of NSAIDs has emerged, and NSAIDs have been linked to several cardiovascular adverse events, such as myocardial infarction, heart failure, and stroke. Cardiac arrest is the ultimate and most dreaded adverse drug event… We aimed to assess the association between NSAID use and the risk of out-of-hospital cardiac arrest.
Source: European Heart Journal - June 13, 2017 Category: Cardiology Source Type: research
Comparison of coronary artery calcification, carotid intima-media thickness and ankle-brachial index for predicting 10-year incident cardiovascular events in the general population
ConclusionCoronary artery calcification provides the best discrimination of risk compared with CIMT and ABI, particularly in the intermediate risk group, whereas CIMT may be an alternative measure for reassurance in the low risk group.
Source: European Heart Journal - March 30, 2017 Category: Cardiology Source Type: research
Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the Standard care vs. Celecoxib Outcome Trial (SCOT)
This study excluded an increased risk of the primary endpoint of more than two events per 1000 patient-years associated with switching to prescribed celecoxib.Clinical Trial Registrationhttps://clinicaltrials.gov/show/NCT00447759; Unique identifier: NCT00447759.
Source: European Heart Journal - October 4, 2016 Category: Cardiology Source Type: research
Impact of the SYNTAX scores I and II in patients with diabetes and multivessel coronary disease: a pooled analysis of patient level data from the SYNTAX, PRECOMBAT, and BEST trials
ConclusionsDifferences in 5 years outcomes following PCI and CABG for patients with MVD and diabetes were influenced by anatomic complexity as measured by the SYNTAX score. The SYNTAX score II mortality prediction model showed similar performance regardless of the diabetes status.
Source: European Heart Journal - April 18, 2017 Category: Cardiology Source Type: research
Prediction of adverse events after catheter-based procedures in adolescents and adults with congenital heart disease in the IMPACT registry
ConclusionThe factors predicting adverse events after cardiac catheterization in adolescents and adults with CHD are different than in the general population. Validation of this model in other national or multi-institutional datasets is the next step.
Source: European Heart Journal - April 18, 2017 Category: Cardiology Source Type: research
Insomnia and myocardial infarction
Insomnia associated with increased risk of infarction and stroke according to study
Source: European Heart Journal - July 14, 2017 Category: Cardiology Source Type: research
