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Acute compartment syndrome in a patient with sickle cell disease.
We present a young man with HbSC disease who developed acute compartment syndrome. This is only the second report of this syndrome in a patient with HbSC disease. This is a very rare complication in HbSC disease, but it can have serious implications. PMID: 32777927 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - August 10, 2020 Category: Surgery Authors: Cochrane E, Young S, Shariff Z Tags: Ann R Coll Surg Engl Source Type: research

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

The effects of centralisation of vascular surgical services in the Bath, Bristol and Weston area on the carotid endarterectomy pathway.
Conclusion Centralisation has not significantly impacted the overall efficiency of the carotid endarterectomy pathway. This study highlights areas where improvement across the vascular network is required. This includes addressing the 35% patients that are not currently meeting the 14-day target and standardising the provision of care to outlying communities. Further follow-up is required to assess the longer term effects of centralisation. PMID: 28682128 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - July 6, 2017 Category: Surgery Authors: Partridge E, Brooks M, Curd C, Davis V, Oates C, McGeeney D Tags: Ann R Coll Surg Engl Source Type: research