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Source: Journal of Neuroimmunology
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Total 34 results found since Jan 2013.
Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome
Our study investigated the frequency of interleukin-6 (IL-6) promoter polymorphism rs1800795 (−174 G>C), possible association of this polymorphism with IL-6 levels and the outcome after stroke in 95 patients with acute ischemic stroke and 268 healthy subjects. It shows a significant reduction in the frequency of G alleles in stroke patients compared to healthy controls. Carriage of G allele is not associated with stroke subtypes, the initial severity or the outcome after stroke. The −174 polymorphisms were not associated with variation in IL-6 levels post-stroke.
Source: Journal of Neuroimmunology - February 4, 2016 Category: Allergy & Immunology Authors: J. Yan, Greer JM, McCombe PA Source Type: research
Spectratype analysis of clonal T cell expansion in murine experimental stroke
Abstract: T lymphocytes are major contributors to post-ischemic neuroinflammation following ischemic stroke. However, the mode of postischemic T cell activation remains a controversial issue. Therefore, this study aimed to directly investigate antigen-dependent clonal T cell expansion after experimental brain ischemia using spectratype/immunoscope analysis. We detected clonal T cell expansion in ischemic brains and to a lesser extent in secondary lymphatic organs and characterized its time course. This is the first study presenting direct evidence of clonal T cell expansion after stroke — however, with delayed kinetics t...
Source: Journal of Neuroimmunology - February 26, 2013 Category: Allergy & Immunology Authors: Arthur Liesz, Simone Karcher, Roland Veltkamp Tags: Research Papers Source Type: research
Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke
This study provides new information about the sex specific mechanisms of the peripheral immune response in neurodegeneration after stroke and demonstrates the need for representation of both sexes in basic and clinical stroke research.
Source: Journal of Neuroimmunology - November 25, 2014 Category: Allergy & Immunology Authors: Abby L. Dotson, Jianming Wang, Julie Saugstad, Stephanie J. Murphy, Halina Offner Source Type: research
Circulating Brain Derived Neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: Effect on outcome
The aim of this study was to measure the levels of circulating BDNF and the frequency of BDNF-producing T cells after acute ischaemic stroke. Serum BDNF levels were measured by ELISA. Flow cytometry was used to enumerate peripheral blood leukocytes that were labelled with antibodies against markers of T cells, T regulatory cells (Tregs), and intracellular BDNF. There was a slight increase in serum BDNF levels after stroke. There was no overall difference between stroke patients and controls in the frequency of CD4+ and CD8+ BDNF+ cells, although a subgroup of stroke patients showed high frequencies of these cells.
Source: Journal of Neuroimmunology - July 4, 2015 Category: Allergy & Immunology Authors: Adeline Chan, Jun Yan, Peter Csurhes, Judith Greer, Pamela McCombe Source Type: research
Fatty acid binding protein 4 is associated with stroke risk and severity in patients with acute ischemic stroke
The role of fatty acid-binding proteins (FABPs) in atherosclerosis has been investigated. The aim of this study was to verify the hypothesis that higher levels of serum FABP4 could be a biomarker for stroke and associated with stroke severity in Chinese patients with ischemic stroke.
Source: Journal of Neuroimmunology - July 18, 2017 Category: Allergy & Immunology Authors: Li Chang, Jianlong Zhang, Li Liu, Zhen Huang, Yingbo Han, Yanyan Zhu Source Type: research
Elevated plasma macrophage migration inhibitor factor as a risk factor for the development of post-stroke depression in ischemic stroke
Macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory responses, has been reported to link to the pathophysiology of cardiovascular disease and depression. The aim of this study was to test the possible association between plasma MIF and the development of post-stroke depression (PSD) in Chinese patients with acute ischemic stroke (AIS).
Source: Journal of Neuroimmunology - April 10, 2018 Category: Allergy & Immunology Authors: Tingting Xu, Shuang Pu, Ying Ni, Mingqing Gao, Xuemei Li, Xianwei Zeng Source Type: research
Efficacy and safety of intratracheal IFN- γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections
Stroke-induced immunosuppression contributes to the development of stroke-associated pneumonia (SAP). Experiments in mice demonstrated that apoptosis of IFN- γ producing cells and reduced IFN-γ secretion resulted in impaired immune responses and the development of pneumonia after middle cerebral artery occlusion (MCAo). In the present study, we investigated the efficacy of intratracheal IFN-γ treatment to prevent SAP and demonstrated that modest benef its on pulmonary cytokine response in IFN-γ treated stroke mice did not prevent spontaneously developing infections and even slightly reduced bacterial clearance of aspirated pneumococci.
Source: Journal of Neuroimmunology - April 3, 2021 Category: Allergy & Immunology Authors: Sandra Jagdmann, Daniel Berchtold, Birgitt Gutbier, Martin Witzenrath, Andreas Meisel, Christian Meisel, Claudia Dames Source Type: research
Elevated plasma levels of galectin-3 binding protein are associated with post-stroke delirium – A pilot study
To explore the role of systemic inflammation in post-stroke delirium, we investigated the level of two inflammatory mediators: high mobility group box 1 (HMGB1) and galectin-3 binding protein (Gal-3BP). Of 571 stroke patients, we compared plasma levels of HMGB1 and Gal-3BP in 79 delirious patients with 81 non-delirious patients matched for age and stroke severity. Delirious patients had higher Gal-3BP level (median: 1440 vs 1053 ng/mL, P
Source: Journal of Neuroimmunology - April 16, 2021 Category: Allergy & Immunology Authors: Elzbieta Klimiec-Moskal, Paulina Pasinska, Katarzyna Kowalska, Aleksandra Klimkowicz-Mrowiec, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzic Tags: Short Communication Source Type: research
Ginkgo biloba extract (EGb-761) confers neuroprotection against ischemic stroke by augmenting autophagic/lysosomal signaling pathway
Ginkgo biloba extract (EGb-761) is well-recognized to have neuroprotective properties. Meanwhile, autophagy machinery is extensively involved in the pathophysiological processes of ischemic stroke. The EGb-761 is widely used in the clinical treatment of stroke patients. However, its neuroprotective mechanisms against ischemic stroke are still not fully understood. The present study was conducted to uncover whether the pharmacological effects of EGb-761 can be executed by modulation of the autophagic/lysosomal signaling axis.
Source: Journal of Neuroimmunology - May 4, 2023 Category: Allergy & Immunology Authors: Rui Zang, Fayang Ling, Zhiyuan Wu, Jun Sun, Licong Yang, Zuyin Lv, Nengbo Ji Source Type: research
Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: A systematic review and meta-analysis
Abstract: We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592–5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814–3.033), p
Source: Journal of Neuroimmunology - August 4, 2014 Category: Allergy & Immunology Authors: Alejandro Bustamante, Tomás Sobrino, Dolors Giralt, Teresa García-Berrocoso, Victor Llombart, Iratxe Ugarriza, Marc Espadaler, Noelia Rodríguez, Cathie Sudlow, Mar Castellanos, Craig J. Smith, Manuel Rodríguez-Yánez, Ulrike Waje-Andreassen, David Tan Tags: Clinical Neuroimmunology Source Type: research
Promiscuity of Autoimmune Responses to MBP after Stroke
In this study we examined Th1 and Th17 immune responses to rat myelin basic protein (MBP), bovine MBP, human MBP, MBP 68-86, MBP 63-81 and ovalbumin in Lewis rats to determine which MBP antigen is recognized following ischemic brain injury. Responses were compared to animals immunized to rat MBP. Data show that immune responses following immunization with rat MBP are promiscuous with cross reaction to MBP from other species. After stroke, few animals develop Th1 or Th17 responses to MBP, but when those responses occur, especially Th1 responses to rat MBP in brain, they are predictive of worse stroke outcome.
Source: Journal of Neuroimmunology - May 28, 2015 Category: Allergy & Immunology Authors: Dannielle Zierath, Allison Kunze, Leia Fecteau, Kyra Becker Source Type: research
Plasma endotoxin activity rises during ischemic stroke and is associated with worse short-term outcome
Activation of Toll-like receptor 4 (TLR4) contributes to brain injury and poor outcome after cerebral ischemia. The expression of this receptor on monocytes is increased in patients with acute ischemic stroke. Endotoxin is an endogenous ligand for TLR4. The aim of our study was to determine if plasma endotoxin activity is increased in stroke patients and correlates with functional outcome.
Source: Journal of Neuroimmunology - May 8, 2016 Category: Allergy & Immunology Authors: Elzbieta Klimiec, Joanna Pera, Joanna Chrzanowska-Wasko, Aleksandra Golenia, Agnieszka Slowik, Tomasz Dziedzic Source Type: research
Association of lower serum Brain-derived neurotrophic factor levels with larger infarct volumes in acute ischemic stroke
Brain-derived neurotrophic factor (BDNF) plays a potential role in stroke recovery, as it promotes plasticity. The aim of this study is to investigate the association between infarct volume using DWI and BDNF at admission in patients with acute ischemic stroke (AIS).
Source: Journal of Neuroimmunology - April 4, 2017 Category: Allergy & Immunology Authors: Hui-Jie Qiao, Zhen-Zhi Li, Li-Ming Wang, Wei Sun, Jin-Chao Yu, Bin Wang Source Type: research
FasL incapacitation alleviates CD4+ T cells-induced brain injury through remodeling of microglia polarization in mouse ischemic stroke
In this study, we demonstrated that CD4+ T cells could induce M1 microglia polarization through NF- κB signaling pathway, whereas FasL mutant CD4+ T cells significantly reversed this effect. Besides, Th17/Treg cells balance was skewed into Treg cells after FasL mutation.
Source: Journal of Neuroimmunology - February 2, 2018 Category: Allergy & Immunology Authors: Haoran Zhao, Lihua Wan, Yan Chen, He Zhang, Yun Xu, Shuwei Qiu Source Type: research
