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Source: Journal of Neuroimmunology
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Total 34 results found since Jan 2013.
Palmatine, a natural alkaloid, attenuates memory deficits and neuroinflammation in mice submitted to permanent focal cerebral ischemia
Ischemic stroke is one of the major causes of human morbidity and mortality. The pathophysiology of ischemic stroke involves complex events, including oxidative stress and inflammation, that lead to neuronal loss and cognitive deficits. Palmatine (PLT) is a naturally occurring (Coptidis rhizome) isoquinoline alkaloid that belongs to the class of protoberberines and has a wide spectrum of pharmacological and biological effects. In the present study, we evaluated the impact of Palmatine on neuronal damage, memory deficits, and inflammatory response in mice submitted to permanent focal cerebral ischemia induced by middle cere...
Source: Journal of Neuroimmunology - June 17, 2023 Category: Allergy & Immunology Authors: Juliana Fernandes Pereira, Juliana Catharina de Sousa Neves, Analu Arag ão Fonteles, Jéssica Rabelo Bezerra, Rayssa Costa Pires, Ana Thais Araújo da Silva, Francisco Arnaldo Viana Lima, Kelly Rose Tavares Neves, Reinaldo Barreto Oriá, Glauce Socorro d Source Type: research
Ginkgo biloba extract (EGb-761) confers neuroprotection against ischemic stroke by augmenting autophagic/lysosomal signaling pathway
Ginkgo biloba extract (EGb-761) is well-recognized to have neuroprotective properties. Meanwhile, autophagy machinery is extensively involved in the pathophysiological processes of ischemic stroke. The EGb-761 is widely used in the clinical treatment of stroke patients. However, its neuroprotective mechanisms against ischemic stroke are still not fully understood. The present study was conducted to uncover whether the pharmacological effects of EGb-761 can be executed by modulation of the autophagic/lysosomal signaling axis.
Source: Journal of Neuroimmunology - May 4, 2023 Category: Allergy & Immunology Authors: Rui Zang, Fayang Ling, Zhiyuan Wu, Jun Sun, Licong Yang, Zuyin Lv, Nengbo Ji Source Type: research
Calcitriol modulate post-ischemic TLR signaling pathway in ischemic stroke patients
This study aimed to determine the modulat ory effects of calcitriol hormone on post-ischemic immunity response.
Source: Journal of Neuroimmunology - December 26, 2022 Category: Allergy & Immunology Authors: Saeedeh Tajalli-Nezhad, Salimeh Mohammadi, Mohammad Ali Atlasi, Mahdi Kheiran, Sepideh Etehadi Moghadam, Homayoun Naderian, Abolfazl Azami Tameh Source Type: research
Pilot study in human healthy volunteers on the mechanisms underlying remote ischemic conditioning (RIC) – Targeting circulating immune cells and immune-related proteins
Remote ischemic conditioning (RIC) is a novel promising therapy for treatment of neurological diseases, including ischemic stroke. RIC consists of short cycles of ischemia in a distant non-vital organ that may protect other organs against ischemia. Extensive experimental data and some few clinical trials support the neuroprotective role of RIC in ischemic stroke. Nevertheless, the circulating factors involved in this inter-organ communication and neuroprotection are not clarified. This pilot study in humans characterized the innate and adaptive circulating immune cell populations following RIC.
Source: Journal of Neuroimmunology - March 18, 2022 Category: Allergy & Immunology Authors: In ês Mollet, Catarina Martins, Miguel Ângelo-Dias, Ana S. Carvalho, Kerman Aloria, Rune Matthiesen, Miguel Viana Baptista, Luís Miguel Borrego, Helena L.A. Vieira Source Type: research
Increased serum interleukin-34 levels as a novel diagnostic and prognostic biomarker in patients with acute ischemic stroke
Recent data reveal that interleukin-34 (IL-34) can drive inflammatory response, thereby participating in the pathogenesis of inflammatory diseases. However, the potential effect of IL-34 in acute ischemic stroke (AIS) remains unknown. The purpose of this study was to explore whether the levels of serum IL-34 were correlated with clinical severity or prognosis in AIS patients.
Source: Journal of Neuroimmunology - June 29, 2021 Category: Allergy & Immunology Authors: Xiaoyu Huang, Fengzhan Li, Tingting Yang, Hao Li, Tan Liu, Yingying Wang, Minmin Xu, Lisha Yan, Yong Zhang, Yuzhong Wang, Linlin Fu, Deqin Geng Source Type: research
Diagnosing SARS-CoV-2 associated Guillain-Barre syndrome requires cerebro-spinal-fluid studies
We read with interest the article by Papri et al. about a 50yo male who was diagnosed with Guillain Barre syndrome (GBS) subtype acute inflammatory demyelinating polyneuropathy (AIDP) according to the National Institute of Neurological Disorders and Stroke (NINDS) criteria upon the clinical presentation and nerve conduction studies (NCSs) 6 weeks after onset of an infection with SARS-CoV-2 (Papri et al., 2021). The patient received immunoglobulines and recovered slowly but almost completely over a period of 6 months (Papri et al., 2021).
Source: Journal of Neuroimmunology - May 13, 2021 Category: Allergy & Immunology Authors: Josef Finsterer, Fulvio A. Scorza, Carla A. Scorza, Ana C. Fiorini Tags: Letter to the Editor Source Type: research
Elevated plasma levels of galectin-3 binding protein are associated with post-stroke delirium – A pilot study
To explore the role of systemic inflammation in post-stroke delirium, we investigated the level of two inflammatory mediators: high mobility group box 1 (HMGB1) and galectin-3 binding protein (Gal-3BP). Of 571 stroke patients, we compared plasma levels of HMGB1 and Gal-3BP in 79 delirious patients with 81 non-delirious patients matched for age and stroke severity. Delirious patients had higher Gal-3BP level (median: 1440 vs 1053 ng/mL, P
Source: Journal of Neuroimmunology - April 16, 2021 Category: Allergy & Immunology Authors: Elzbieta Klimiec-Moskal, Paulina Pasinska, Katarzyna Kowalska, Aleksandra Klimkowicz-Mrowiec, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzic Tags: Short Communication Source Type: research
Efficacy and safety of intratracheal IFN- γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections
Stroke-induced immunosuppression contributes to the development of stroke-associated pneumonia (SAP). Experiments in mice demonstrated that apoptosis of IFN- γ producing cells and reduced IFN-γ secretion resulted in impaired immune responses and the development of pneumonia after middle cerebral artery occlusion (MCAo). In the present study, we investigated the efficacy of intratracheal IFN-γ treatment to prevent SAP and demonstrated that modest benef its on pulmonary cytokine response in IFN-γ treated stroke mice did not prevent spontaneously developing infections and even slightly reduced bacterial clearance of aspirated pneumococci.
Source: Journal of Neuroimmunology - April 3, 2021 Category: Allergy & Immunology Authors: Sandra Jagdmann, Daniel Berchtold, Birgitt Gutbier, Martin Witzenrath, Andreas Meisel, Christian Meisel, Claudia Dames Source Type: research
Post-stroke inflammatory response is linked to volume loss in the contralateral hemisphere
In this study, we assessed the magnitude of cerebral volume loss in the unaffected contralateral hemisphere following stroke, and determined its relationship with inflammatory cascades.
Source: Journal of Neuroimmunology - April 20, 2020 Category: Allergy & Immunology Authors: Serhat V. Okar, Mehmet A. Topcuoglu, Muge Yemisci, Canan Cakir Aktas, Kader K. Oguz, Ethem M. Arsava Source Type: research
Data inclusion in the article: A meta-analysis on associations of IL-6 and IL-10 polymorphisms with susceptibility to ischemic stroke
Recently we took great interest to read a meta-analysis by Chen and his colleagues presenting the association of IL-6 and IL-10 polymorphisms with ischemic stroke (IS) susceptibility. The author found that IL-6 rs1800795 polymorphism was significantly associated with susceptibility to IS in Asians, but not in Caucasians(Chen and Yang, 2019). It's a very significant study. However, there are some questions about the data inclusion of this meta-analysis we would like to communicate with the authors.
Source: Journal of Neuroimmunology - December 18, 2019 Category: Allergy & Immunology Authors: Dongmei Huang Tags: Letter to the editor Source Type: research
A meta-analysis on associations of IL-6 and IL-10 polymorphisms with susceptibility to ischemic stroke
Some previous studies already explored associations of interleukin-6 (IL-6) and interleukin-10 (IL-10) polymorphisms with ischemic stroke (IS). However, the results were conflicting. In this meta-analysis, we aimed to better analyze the relationship between IL-6/IL-10 polymorphisms and IS in a larger pooled population.
Source: Journal of Neuroimmunology - July 8, 2019 Category: Allergy & Immunology Authors: Miao Chen, Yue Yang Source Type: research
Prognostic value of copeptin in patients with aneurysmal subarachnoid hemorrhage
This study investigated the prognostic value of copeptin in the patients with aneurysmal subarachnoid hemorrhage(aSAH).
Source: Journal of Neuroimmunology - March 7, 2019 Category: Allergy & Immunology Authors: Zhizhi Zuo, Xiang Ji Source Type: research
T cells in the post-ischemic brain: Troopers or paramedics?
The immune system is intricately involved in brain development and physiological neuronal function. The influence of the adaptive immune system on several brain diseases has been described in great detail. In ischemic stroke, numerous studies have particularly demonstrated a key role for T cells during the acute phase after the brain injury. Recently, a critical role for T cells has also become more evident for the chronic phase after stroke in modulating delayed neuronal (dys-) function and recovery.
Source: Journal of Neuroimmunology - November 13, 2018 Category: Allergy & Immunology Authors: Julia V. Cramer, Corinne Benakis, Arthur Liesz Tags: Review Article Source Type: research
Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target
Polymorphonuclear neutrophil granulocytes (PMN) orchestrate the removal of cell debris in ischemic stroke and intracerebral hemorrhage. In both pathologies, high neutrophil to lymphocyte ratios in peripheral blood are predictive of poor outcome in human stroke patients. Following earlier studies indicating that the cerebral microvasculature forms an efficient barrier that impedes neutrophil brain entry, intravital microscopy and immunohistochemistry in the meantime unequivocally revealed the accumulation of PMN in the ischemic and hemorrhagic brain parenchyma.
Source: Journal of Neuroimmunology - April 24, 2018 Category: Allergy & Immunology Authors: Dirk M. Hermann, Christoph Kleinschnitz, Matthias Gunzer Tags: Review Article Source Type: research
