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Why Being An Optimist Is Good For Your Heart
(CNN) — Looking on the bright side could save your life. People who look at life from a positive perspective have a much stronger shot at avoiding death from any type of cardiovascular risk than pessimistic people, according to a new meta-analysis of nearly 300,000 people published Friday in the medical journal JAMA. “We observed that an optimist had about a 35% lower risk of major heart complications, such as a cardiac death, stroke or a heart attack, compared to the pessimists in each of these studies,” said cardiologist Dr. Alan Rozanski, a professor of medicine at the Icahn School of Medicine at Mount...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 27, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Offbeat CNN Source Type: news

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research