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Validation of olfactory deficit as a biomarker of Alzheimer disease
Conclusions: Olfactory identification deficit is a useful screening tool for AD-related amnestic disorder, with sensitivity and specificity comparable to other established biomarkers, with benefits such as ease of administration and low cost. Olfactory identification deficit can be utilized to stratify risk of conversion from aMCI to AD and enrich clinical trials of disease-modifying therapy. Classification of evidence: This study provides Class III evidence that smell identification (10-item UPSIT subset) accurately identifies patients with amnestic disorders.
Source: Neurology Clinical Practice - February 12, 2017 Category: Neurology Authors: Woodward, M. R., Amrutkar, C. V., Shah, H. C., Benedict, R. H. B., Rajakrishnan, S., Doody, R. S., Yan, L., Szigeti, K., On behalf of the Texas Alzheimer Research and Care Consortium Tags: Alzheimer's disease, Class III, MCI (mild cognitive impairment) Research Source Type: research

Neuropsychologic assessment in collaborative Parkinson’s disease research: A proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson’s Disease Research at the University of Pennsylvania and the University of Washington
Abstract: Cognitive impairment (CI) and behavioral disturbances can be the earliest symptoms of Parkinson's disease (PD), ultimately afflict the vast majority of PD patients, and increase caregiver burden. Our two Morris K. Udall Centers of Excellence for Parkinson's Disease Research were supported by the National Institute of Neurological Disorders and Stroke (NINDS) in an effort to recommend a comprehensive yet practical approach to cognitive and behavioral assessment to further collaborative research. We recommend a stepwise approach with two levels of standardized evaluation to establish a common battery, as well as an...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2012 Category: Geriatrics Authors: G. Stennis Watson, Brenna A. Cholerton, Rachel G. Gross, Daniel Weintraub, Cyrus P. Zabetian, John Q. Trojanowski, Thomas J. Montine, Andrew Siderowf, James B. Leverenz Tags: Perspectives Source Type: research