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Source: Atherosclerosis
Drug: Insulin
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Total 48 results found since Jan 2013.
Novel biomarkers and emerging tools to identify causal molecular pathways in hypertension and associated cardiovascular diseases
Kardiol Pol. 2023 Feb 5. doi: 10.33963/KP.a2023.0037. Online ahead of print.ABSTRACTHypertension (HT) is a modifiable risk factor for life-threatening cardiovascular diseases (CVDs) including coronary artery disease, heart failure or stroke. Despite significant progress in understanding of the pathophysiological mechanisms of the disease, the molecular pathways targeted by HT treatment still remain largely unchanged. This warrants the necessity for searching novel biomarkers, which are causally related to persistent high blood pressure (BP) and may be pharmacologically targeted. Data from large-scale biobanks, containing h...
Source: Atherosclerosis - February 5, 2023 Category: Cardiology Authors: Ewelina J ózefczuk Tomasz J Guzik Mateusz Siedlinski Source Type: research
Association of hyperuricemia with cardiovascular diseases: current evidence
Hosp Pract (1995). 2023 Feb 2. doi: 10.1080/21548331.2023.2173413. Online ahead of print.ABSTRACTThe aim of the present study is to present a historical and unified perspective on the association of serum uric acid (SUA) in the cause cardiovascular diseases (CVDs). The association of hyperuricemia (HUC) with CVD begun to be appreciated in the middle 1950s and early 1990s when clinical evidence was shown on the association of HUC with CVD. However, this association was disputed by several investigators including the Framingham group and by professional societies, like the American Heart Association and the American Society ...
Source: Atherosclerosis - February 2, 2023 Category: Cardiology Authors: Steven G Chrysant Source Type: research
Triglyceride-glucose index and the incidence of stroke: A meta-analysis of cohort studies
CONCLUSION: A higher TyG index may be independently associated with a higher risk of stroke in individuals without stroke at baseline. The aforementioned findings need to be verified by a large-scale prospective cohort study to further clarify the underlying pathophysiological mechanism between the TyG index and stroke.PMID:36686534 | PMC:PMC9845890 | DOI:10.3389/fneur.2022.1033385
Source: Atherosclerosis - January 23, 2023 Category: Cardiology Authors: Canlin Liao Haixiong Xu Tao Jin Ke Xu Zhennan Xu Lingzhen Zhu Mingfa Liu Source Type: research
The role of miRNAs in insulin resistance and diabetic macrovascular complications - A review
Int J Biol Macromol. 2023 Jan 6:123189. doi: 10.1016/j.ijbiomac.2023.123189. Online ahead of print.ABSTRACTDiabetes is the most prevalent metabolic disturbance disease and has been regarded globally as one of the principal causes of mortality. Diabetes is accompanied by several macrovascular complications, including stroke, coronary artery disease (CAD), and cardiomyopathy as a consequence of atherosclerosis. The onset of type 2 diabetes is closely related to insulin resistance (IR). miRNAs have been linked to various metabolic processes, including glucose homeostasis, regulation of lipid metabolism, gluconeogenesis, adipo...
Source: Atherosclerosis - January 9, 2023 Category: Cardiology Authors: Sherif S Abdel Mageed Ahmed S Doghish Ahmed Ismail Ahmed A El-Husseiny Sylvia F Fawzi Abdulla M A Mahmoud Hesham A El-Mahdy Source Type: research
Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
Front Endocrinol (Lausanne). 2022 Dec 15;13:1092431. doi: 10.3389/fendo.2022.1092431. eCollection 2022.ABSTRACTThe pathological condition of insulin resistance prevents the neuroprotective effects of insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk factor for ischemic stroke, accelerates the formation of thrombosis and promotes the development of atherosclerosis, both of which are major mechanisms of ischemic stroke. Additionally, insulin resistance negatively affects the prognosis of patients with ischemic stroke regardless of whether the patient has diabetes, but the mechanisms ...
Source: Atherosclerosis - January 2, 2023 Category: Cardiology Authors: Peng-Fei Ding Hua-Sheng Zhang Jie Wang Yong-Yue Gao Jian-Nan Mao Chun-Hua Hang Wei Li Source Type: research
Triglyceride-glucose index as a prognostic marker after ischemic stroke or transient ischemic attack: a prospective observational study
CONCLUSIONS: TyG index is associated with cervicocerebral atherosclerosis and the MACE risk after a stroke, suggesting the potential value of TyG index to optimize the risk stratification of stroke patients. Trial registration URL: https://upload.umin.ac.jp . Unique identifier: UMIN000031913.PMID:36451149 | DOI:10.1186/s12933-022-01695-2
Source: Atherosclerosis - November 30, 2022 Category: Cardiology Authors: Takao Hoshino Takafumi Mizuno Kentaro Ishizuka Shuntaro Takahashi Satoko Arai Sono Toi Kazuo Kitagawa Source Type: research
How dysregulation of the immune system promotes diabetes mellitus and cardiovascular risk complications
Front Cardiovasc Med. 2022 Sep 29;9:991716. doi: 10.3389/fcvm.2022.991716. eCollection 2022.ABSTRACTDiabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin resistance or failure to produce insulin. Patients with DM develop microvascular complications that include chronic kidney disease and retinopathy, and macrovascular complications that mainly consist in an accelerated and more severe atherosclerosis compared to the general population, increasing the risk of cardiovascular (CV) events, such as stroke or myocardial infarction by 2- to 4-fold. DM is commonly associate...
Source: Atherosclerosis - October 17, 2022 Category: Cardiology Authors: Diane Girard Claire Vandiedonck Source Type: research
Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning
CONCLUSION: M1 macrophages is an important cause of unstable plaque formation, and CD68, PAM, and IGFBP6 could be used as diagnostic markers to identify unstable plaques effectively.PMID:36211422 | PMC:PMC9537477 | DOI:10.3389/fimmu.2022.956078
Source: Atherosclerosis - October 10, 2022 Category: Cardiology Authors: Jing Wang Zijian Kang Yandong Liu Zifu Li Yang Liu Jianmin Liu Source Type: research
Well-posedness of a mathematical model of diabetic atherosclerosis with advanced glycation end-products
Appl Anal. 2022;101(11):3989-4013. doi: 10.1080/00036811.2022.2060210. Epub 2022 Apr 6.ABSTRACTAtherosclerosis is a leading cause of death worldwide; it emerges as a result of multiple dynamical cell processes including hemodynamics, endothelial damage, innate immunity and sterol biochemistry. Making matters worse, nearly 463 million people have diabetes, which increases atherosclerosis-related inflammation, diabetic patients are twice as likely to have a heart attack or stroke. The pathophysiology of diabetic vascular disease is generally understood. Dyslipidemia with increased levels of atherogenic LDL, hyperglycemia, ox...
Source: Atherosclerosis - October 3, 2022 Category: Cardiology Authors: Xuming Xie Source Type: research
Crosstalk between neurological, cardiovascular, and lifestyle disorders: insulin and lipoproteins in the lead role
Pharmacol Rep. 2022 Sep 23. doi: 10.1007/s43440-022-00417-5. Online ahead of print.ABSTRACTInsulin resistance and impaired lipoprotein metabolism contribute to a plethora of metabolic and cardiovascular disorders. These alterations have been extensively linked with poor lifestyle choices, such as consumption of a high-fat diet, smoking, stress, and a redundant lifestyle. Moreover, these are also known to increase the co-morbidity of diseases like Type 2 diabetes mellitus and atherosclerosis. Under normal physiological conditions, insulin and lipoproteins exert a neuroprotective role in the central nervous system. However, ...
Source: Atherosclerosis - September 23, 2022 Category: Cardiology Authors: Richa Tyagi Bhupesh Vaidya Shyam Sunder Sharma Source Type: research
Association of the triglyceride-glucose index and vascular target organ damage in a Beijing community-based population
CONCLUSIONS: The TyG index was positively associated with artery stiffness and nephric microvascular damage in a Beijing community-based population in China. This result provides evidence that the TyG index may serve as a simple and effective indicator to reflect vascular TOD.PMID:35966556 | PMC:PMC9366355 | DOI:10.3389/fcvm.2022.948402
Source: Atherosclerosis - August 15, 2022 Category: Cardiology Authors: Wenjun Ji Lan Gao Pengfei Sun Jia Jia Jianping Li Xingang Wang Fangfang Fan Yan Zhang Source Type: research
Fibronectin containing alternatively spliced extra domain A interacts at the central and c-terminal domain of Toll-like receptor-4
In conclusion, FN-EDA interacts and forms a stable complex through its "SPEDGIRELF" sequence at the central and C-terminal domain region of TLR4. The revelation of FN-EDA and TLR4 interacting sites may help design novel therapeutics for drug discovery research.PMID:35690624 | DOI:10.1038/s41598-022-13622-2
Source: Atherosclerosis - June 11, 2022 Category: Cardiology Authors: Shubhangi Gupta Azeem Ali Saurabh Pandey Imran A Khan Prem Prakash Source Type: research
