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Botulinum Toxin Modulates Posterior Parietal Cortex Activation in Post-stroke Spasticity of the Upper Limb
Post-stroke spasticity (PSS) is effectively treated with intramuscular botulinum toxin type A (BoNT-A), although the clinical improvement is likely mediated by changes at the central nervous system level. Using functional magnetic resonance imaging (fMRI) of the brain, this study aims to confirm and locate BoNT-A-related changes during motor imagery with the impaired hand in severe PSS. Temporary alterations in primary and secondary sensorimotor representation of the impaired upper limb were expected. Thirty chronic stroke patients with upper limb PSS undergoing comprehensive treatment including physiotherapy and indicat...
Source: Frontiers in Neurology - May 8, 2019 Category: Neurology Source Type: research

Detection of Botulinum Toxin Muscle Effect in Humans Using Magnetic Resonance Imaging: A Qualitative Case Series
Conclusions This descriptive case series is among the first attempts to quantify BTME within human muscle. Our findings are preliminary and are limited by a few inconsistencies. However, we conclude that use of magnetic resonance imaging to detect the volume of BTME is feasible and may assist researchers in modeling the spread and diffusion of BT within human muscle. Level of Evidence To be determined.
Source: PMandR - May 31, 2017 Category: Rehabilitation Source Type: research

Combined effects of robot-assisted gait training and botulinum toxin type A effect on spastic equinus foot in patients with chronic stroke: a pilot, single blind, randomized controlled trial.
CONCLUSIONS: Our preliminary findings support the hypothesis that robot-assisted gait training does not enhance the effect of botulinum toxin type A on spastic equinus foot in patients with chronic stroke. CLINICAL REHABILITATION IMPACT: Our observations should be taken into account in daily clinical rehabilitation practice in order to develop effective treatment protocols based on the enhancement of antispastic drugs effect. PMID: 27098300 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - April 20, 2016 Category: Rehabilitation Authors: Picelli A, Bacciga M, Melotti C, LA Marchina E, Verzini E, Ferrari F, Pontillo A, Corradi J, Tamburin S, Saltuari L, Corradini C, Waldner A, Smania N Tags: Eur J Phys Rehabil Med Source Type: research