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GLT-1 transporter: An effective pharmacological target for various neurological disorders
Publication date: Available online 13 October 2014 Source:Pharmacology Biochemistry and Behavior Author(s): Neha Soni , B.V.K. Reddy , Puneet Kumar l-Glutamate is the predominant excitatory neurotransmitter in the central nervous system (CNS) and is directly and indirectly involved in a variety of brain functions. Glutamate is released in the synaptic cleft at a particular concentration that further activates the various glutaminergic receptors. This concentration of glutamate in the synapse is maintained by either glutamine synthetase or excitatory amino acid proteins which reuptake the excessive glutamate from the syna...
Source: Pharmacology Biochemistry and Behavior - November 6, 2014 Category: Biochemistry Source Type: research