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Source: Cellular and Molecular Life Sciences : CMLS
Drug: Tamoxifen
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Total 2 results found since Jan 2013.
The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia
This study is the first to show a role of SIK3 in Mi/MΦ phagocytosis in CNS diseases, and reveals that promoting Mi/MΦ anti-inflammatory heterogenization inhibits "excessive phagocytosis" of live cells and facilitates "normal phagocytosis" of apoptotic cells. Therefore, inhibition of SIK3 in Mi/MΦ may be a potential therapeutic target in stroke and other CNS diseases with accompanying white matter destruction. In the acute stage of tFCI, Mi/MΦ polarized into different phenotypes. The pro-inflammatory Mi/MΦ phenotype performed an excessive phagocytotic function. In contrast, the anti-inflammatory Mi/MΦ phenotype perfo...
Source: Cellular and Molecular Life Sciences : CMLS - July 21, 2022 Category: Cytology Authors: Ke Wang Chenran Wang Di Chen Yichen Huang Jiaying Li Pengju Wei Ziyu Shi Yue Zhang Yanqin Gao Source Type: research
