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Cardiotoxicity of Sequential Aromatase Inhibitors Use in Women with Breast Cancer.
Abstract The association between aromatase inhibitors and cardiovascular outcomes is controversial. While some observational studies have assessed their cardiovascular safety as up-front treatments, their cardiotoxic effects as sequential treatments with tamoxifen remains unknown. Thus, we conducted a population-based cohort study using the United Kingdom Clinical Practice Research Datalink linked to the Hospital Episode Statistics and Office for National Statistics databases. A prevalent new-user design was used to propensity score match, in a 1:2 ratio, patients switching from tamoxifen to aromatase inhibitors t...
Source: Am J Epidemiol - April 26, 2020 Category: Epidemiology Authors: Khosrow-Khavar F, Bouganim N, Filion KB, Suissa S, Azoulay L Tags: Am J Epidemiol Source Type: research