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Source: Acta Pharmacologica Sinica
Drug: Carbidopa/Levodopa
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Total 1 results found since Jan 2013.
Exogenous glutathione exerts a therapeutic effect in ischemic stroke rats by interacting with intrastriatal dopamine
Acta Pharmacol Sin. 2021 May 25. doi: 10.1038/s41401-021-00650-3. Online ahead of print.ABSTRACTWe previously showed that oral administration of exogenous glutathione (GSH) exerted a direct and/or indirect therapeutic effect on ischemic stroke rats, but the underlying mechanisms remain elusive. In the current study, we conducted a quantitative proteomic analysis to explore the pathways mediating the therapeutic effect of GSH in cerebral ischemia/reperfusion (I/R) model rats. Rats were subjected to middle cerebral artery occlusion (MCAO) for 2 h followed by reperfusion. The rats were treated with GSH (250 mg/kg, ig) or levo...
Source: Acta Pharmacologica Sinica - May 26, 2021 Category: Drugs & Pharmacology Authors: He Wang Yi-Sha Du Wen-Shuo Xu Chang-Jian Li Hong Sun Kang-Rui Hu Yuan-Zhuo Hu Teng-Jie Yu Hui-Min Guo Lin Xie Guang-Ji Wang Yan Liang Source Type: research
