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Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers.
Abstract Hemorrhagic transformation (HT) is a common and serious complication following ischemic stroke, especially after tissue plasminogen activator (t-PA) thrombolysis, which is associated with increased mortality and disability. Due to the unknown mechanisms and targets of HT, there are no effective therapeutic drugs to decrease the incidence of HT. In recent years, many studies have found that neuroinflammation is closely related to the occurrence and development of HT after t-PA thrombolysis, including glial cell activation in the brain, peripheral inflammatory cell infiltration and the release of inflammato...
Source: International Immunopharmacology - December 6, 2020 Category: Allergy & Immunology Authors: Ma G, Pan Z, Kong L, Du G Tags: Int Immunopharmacol Source Type: research

Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke
Conclusion: We demonstrated that minocycline can ameliorate ischemia-induced brain damage via inhibiting NLRP3 inflammasome activation.Neuroimmunomodulation
Source: Neuroimmunomodulation - November 15, 2016 Category: Allergy & Immunology Source Type: research