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18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis
Conclusion: 18F-FAC PET can visualize brain-infiltrating leukocytes in a mouse MS model and can monitor the response of these cells to an immunomodulatory drug. Translating this strategy into humans will require exploring additional radiotracers.
Source: Journal of Nuclear Medicine - April 30, 2020 Category: Nuclear Medicine Authors: Chen, B. Y., Ghezzi, C., Villegas, B., Quon, A., Radu, C. G., Witte, O. N., Clark, P. M. Tags: Basic Source Type: research

Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation
Abstract Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are ubiquitously expressed. S1P-S1PR signaling has been well characterized in immune trafficking and activation in innate and adaptive immune systems. However, the full extent of its involvement in the pathogenesis of autoimmune diseases is not well understood. FTY720 (fingolimod), a non-selective S1PR modulator, significantly decreased annualized relapse rates in relapsing-remitting multiple sclerosis (MS). FTY720, which primarily targets S1P receptor 1 as a functional antagonist, arrests lymphocyte egress from secondary lymphoid tissues and reduce...
Source: Drugs - June 17, 2016 Category: Drugs & Pharmacology Source Type: research

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - October 25, 2015 Category: Molecular Biology Source Type: research