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Acrolein is involved in ischemic stroke-induced neurotoxicity through spermidine/spermine-N1-acetyltransferase activation.
CONCLUSION: Overall, our current results demonstrate that acrolein is a culprit of neuronal damage through GSH depletion in stroke patients. The mechanism underlying the role of acrolein in stroke-related neuronal damage occurs through SSAT-induced polyamine oxidation by NF-kB pathway activation. These results provide a novel mechanism of neurotoxicity in stroke patients, aid in the development of neutralizing or preventive measures, and further our understanding of neural protection. PMID: 31629858 [PubMed - as supplied by publisher]
Source: Experimental Neurology - October 16, 2019 Category: Neurology Authors: Liu JH, Wang TW, Lin YY, Ho WC, Tsai HC, Chen SP, Lin AM, Liu TY, Wang HT Tags: Exp Neurol Source Type: research

N ‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with PGE2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - October 7, 2018 Category: Neurology Authors: Saravanan S. Karuppagounder, Lauren Alin, Yingxin Chen, David Brand, Megan W. Bourassa, Kristen Dietrich, Cassandra M. Wilkinson, Colby A. Nadeau, Amit Kumar, Steve Perry, John T. Pinto, Victor Darley ‐Usmar, Stephanie Sanchez, Ginger L. Mi Tags: Research Article Source Type: research

Protective Effects of Brain Infarction by N-Acetylcysteine Derivatives Basic Sciences
Conclusions—The results indicate that detoxification of acrolein by NAC derivatives is caused through glutathione conjugation with acrolein catalyzed by glutathione S-transferases, which can be stabilized by NAC derivatives. This is a new concept of acrolein detoxification by NAC derivatives.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Takeshi Uemura, Kenta Watanabe, Kenta Ko, Kyohei Higashi, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama, Koichi Takao, Yoshiaki Sugita, Akihiko Sakamoto, Yusuke Terui, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi Tags: Animal Models of Human Disease, Ischemia, Oxidant Stress, Ischemic Stroke Original Contributions Source Type: research

N ‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with PGE2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
Annals of Neurology,Volume 0, Issue ja, -Not available-.
Source: Annals of Neurology - October 8, 2018 Category: Neurology Authors: Saravanan S. Karuppagounder, Lauren Alin, Yingxin Chen, David Brand, Megan W. Bourassa, Kristen Dietrich, Cassandra M. Wilkinson, Colby A. Nadeau, Amit Kumar, Steve Perry, John T. Pinto, Victor Darley ‐Usmar, Stephanie Sanchez, Ginger L. Mi Source Type: research