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Modafinil May Alleviate Poststroke Fatigue: A Randomized, Placebo-Controlled, Double-Blinded Trial Clinical Sciences
Conclusions— There were no significant differences between the 2 groups with regard to the primary end point. There were secondary significant outcomes that should be explored in future trials. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01800097.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Poulsen, M. B., Damgaard, B., Zerahn, B., Overgaard, K., Rasmussen, R. S. Tags: Behavioral/Psychosocial Treatment Clinical Sciences Source Type: research

Pharmacological interventions for depression in people with traumatic brain injury: systematic review
Conclusion Some pharmacological interventions appear to improve depressive symptoms, anxiety symptoms and quality of life in people with depression and traumatic brain injury. However, the evidence is limited. There is a paucity of evidence for the effectiveness of other pharmacological interventions used in depression in this particular patient group.
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 9, 2014 Category: Neurosurgery Authors: Vattakatuchery, J., Lathif, N., Joy, J., Cavanna, A., Rickards, H. Tags: Neurological injury, Stroke, Trauma CNS / PNS, Mood disorders (including depression), Trauma, Injury POSTER ABSTRACTS Source Type: research

The use of stimulant medications for non-core aspects of ADHD and in other disorders.
Abstract Psychostimulants play a central role in the management of ADHD. Here we review the evidence pertaining to the use of methylphenidate, dexamphetamine and related amphetamine salts, the prodrug lisdexamfetamine and modafinil for the management of comorbid ADHD and non-ADHD indications. There is a growing consensus that stimulant medications are helpful at improving the emotional dysregulation and lability, and oppositional and conduct symptoms that are often associated with ADHD. There is some evidence that psychostimulants may improve outcomes in those with treatment resistant depression, reduce negative s...
Source: Neuropharmacology - June 18, 2014 Category: Drugs & Pharmacology Authors: Sinita E, Coghill D Tags: Neuropharmacology Source Type: research

Table of Contents
Abstract Long QT syndrome more likely in patients with HIV, hepatitis C Long‐term treatments for obesity yield results with lifestyle changes Interaction of valproic acid with two drugs Topiramate study signals possible treatment for cocaine dependence Adjunctive modafinil improves depression, lessens fatigue D‐cycloserine, exposure therapy promising for treating PTSD Gabapentin results bode well for alcohol treatment by MDs Vortioxetine shows efficacy in treating major depression Better trials needed for SSRIs in stroke recovery Drug Safety Communication
Source: The Brown University Psychopharmacology Update - February 12, 2014 Category: Psychiatry Source Type: research

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