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Twenty four hours hypothermia has temporary efficacy in reducing brain infarction and inflammation in aged rats
Stroke is a major cause of disability for which no neuroprotective measures are available. Age is the principal nonmodifiable risk factor for this disease. Previously, we reported that exposure to hydrogen sulfide (H2S) for 48 hours post-stroke lowers whole body temperature and confers neuroprotection in aged animals. Since the duration of hypothermia in most clinical trials is between 24 and 48 hrs, we questioned whether 24 hr exposure to gaseous hypothermia confers the same neuroprotective efficacy as 48 hr exposure.
Source: Neurobiology of Aging - November 19, 2015 Category: Neuroscience Authors: Raluca Elena Sandu, Ana-Maria Buga, Adrian Tudor Balseanu, Mihai Moldovan, Aurel Popa-Wagner Source Type: research
