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1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Knowledge and perceptions about perioperative stroke: a cross-sectional survey of patients scheduled for non-neurologic and non-cardiac surgery.
CONCLUSIONS: Patients at higher risk of stroke frequently underestimate their risk of perioperative stroke. The majority of patients had not discussed perioperative stroke prior to anesthetic consultation. PMID: 31531829 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - September 16, 2019 Category: Anesthesiology Authors: Roughead T, Chui J, Gelb AW, Meng L, Sewell D, Flexman AM Tags: Can J Anaesth Source Type: research

Knowledge and perceptions about perioperative stroke: a cross-sectional survey of patients scheduled for non-neurologic and non-cardiac surgery
ConclusionsPatients at higher risk of stroke frequently underestimate their risk of perioperative stroke. The majority of patients had not discussed perioperative stroke prior to anesthetic consultation.
Source: Canadian Journal of Anesthesia - December 17, 2019 Category: Anesthesiology Source Type: research

Anesthetic consideations for endovascular treatment of acute ischemic stroke
ConclusionsTimely intervention for patients with acute ischemic stroke is of utmost importance. Endovascular thrombectomy is a minimally invasive procedure that has evolved over recent decades and improves outcomes for selected patients with ischemic stroke. Anesthesiologists should have a good understanding of potential complications and anesthetic options. Recent randomized trials have shown that both general anesthesia and sedation are associated with good outcomes; the anesthetic approach should be individualized and may vary by institution. Careful monitoring and maintenance of hemodynamic goals are critical, as is ef...
Source: Canadian Journal of Anesthesia - April 22, 2022 Category: Anesthesiology Source Type: research

General anesthesia or conscious sedation for thrombectomy in stroke patients: an updated systematic review and meta-analysis
ConclusionsIn this updated systematic review and meta-analysis, the choice of anesthetic strategy for endovascular treatment of stroke patients did not significantly impact functional outcome as measured with the mRS at three months. Patients managed with general anesthesia may have more frequent successful reperfusion.Trial registrationPROSPERO (CRD42022319368); registered 19 April 2022.
Source: Canadian Journal of Anesthesia - June 2, 2023 Category: Anesthesiology Source Type: research

Anesthesiologists' perception of perioperative stroke risk during non-neurologic and non-cardiac surgery.
PMID: 29150780 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - November 17, 2017 Category: Anesthesiology Authors: Sewell D, Gelb AW, Meng L, Chui J, Flexman AM Tags: Can J Anaesth Source Type: research

Associations of Anemia With Outcomes in Patients With Spontaneous Intracerebral Hemorrhage: A Meta-Analysis
Conclusions: Anemia on admission was associated with higher mortality and an increased risk of poor outcome in patients with ICH. However, the results were limited by the high heterogeneity of included studies. Prospective, multi-center or population-based, large sample cohort studies are needed in the future. Introduction Intracerebral hemorrhage (ICH) is the second most common cause of stroke and a highly lethal disease (1), which still lacks effective therapeutic interventions (2, 3). Although age, baseline ICH volume and neurological status on admission are well-known predictors of outcome of ICH (4), none of t...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research

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