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Source: Stroke
Condition: Disability
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Total 122 results found since Jan 2013.
Neurologic Outcome Predictors in Pediatric Intracerebral Hemorrhage Brief Report
Background and Purpose—Intracerebral hemorrhage is a considerable source of morbidity and mortality. This 3-center study describes outcomes of pediatric intracerebral hemorrhage and identifies 2-year neurological outcome predictors.Methods—Children 29 days to 18 years of age presenting with intracerebral hemorrhage from March 2007 to May 2015 were enrolled prospectively. Exclusion criteria included trauma; intracranial tumor; hemorrhagic transformation of arterial ischemic stroke or cerebral sinovenous thrombosis; isolated subdural, epidural, or subarachnoid hemorrhage; and abnormal baseline neurological function. Intr...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Giulia S. Porcari, Lauren A. Beslow, Rebecca N. Ichord, Daniel J. Licht, Jonathan T. Kleinman, Lori C. Jordan Tags: Pediatrics, Prognosis, Mortality/Survival, Intracranial Hemorrhage Brief Reports Source Type: research
Declining Rate and Severity of Hospitalized Stroke From 2004 to 2013 Clinical Sciences
Background and Purpose—Stroke is a leading cause of morbidity and disability. We assessed trends in rates of hospitalized stroke and stroke severity on admission in a prospective national registry of stroke from 2004 to 2013.Methods—All 6693 acute ischemic strokes and intracerebral hemorrhage in the National Acute Stroke Israeli participants ≥20 years old were included. Data were prospectively collected in 2004 (February–March), 2007 (March–April), 2010 (April–May), and 2013 (March–April). Rates of hospitalized stroke from 2004 to 2013 were studied using generalized linear models assuming a quasi-Poisson erro...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Silvia Koton, Diklah Geva, Jonathan Y. Streifler, Sagi Harnof, Yoav Pougach, Olga Azrilin, Shoshana Hadar, Natan M. Bornstein, David Tanne Tags: Cardiovascular Disease, Epidemiology, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research
Perimesencephalic Hemorrhage Clinical Sciences
Conclusions—A single, high-quality computed tomography angiography is the preferred diagnostic strategy. Short-term complications are rare and often transient. Long-term outcome is excellent with respect to disability and death, but high-quality studies focused at neuropsychological sequelae are needed.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Liselore A. Mensing, Mervyn D.I. Vergouwen, Kamil G. Laban, Ynte M. Ruigrok, Birgitta K. Velthuis, Ale Algra, Gabriel J.E. Rinkel Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Clinical Utility of Electronic Alberta Stroke Program Early Computed Tomography Score Software in the ENCHANTED Trial Database Clinical Sciences
Background and Purpose—Clinical utility of electronic Alberta Stroke Program Early CT Score (e-ASPECTS), an automated system for quantifying signs of infarction, was evaluated in a large database of thrombolyzed patients with acute ischemic stroke.Methods—All baseline noncontrast computed tomographic scans of patients with anterior circulation acute ischemic stroke who participated in the alteplase dose arm of the randomized controlled trial ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) were reviewed; poor quality and large (>6 mm) slice thickness were excluded. Included scans had e-ASPECTS...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Simon Nagel, Xia Wang, Cheryl Carcel, Thompson Robinson, Richard I. Lindley, John Chalmers, Craig S. Anderson Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Blood Pressure-Attained Analysis of ATACH 2 Trial Clinical Sciences
Background and Purpose—We compared the rates of death or disability, defined by modified Rankin Scale score of 4 to 6, at 3 months in patients with intracerebral hemorrhage according to post-treatment systolic blood pressure (SBP)–attained status.Methods—We divided 1000 subjects with SBP ≥180 mm Hg who were randomized within 4.5 hours of symptom onset as follows: SBP
Source: Stroke - May 25, 2018 Category: Neurology Authors: Adnan I. Qureshi, Yuko Y. Palesch, Lydia D. Foster, William G. Barsan, Joshua N. Goldstein, Daniel F. Hanley, Chung Y. Hsu, Claudia S. Moy, Mushtaq H. Qureshi, Robert Silbergleit, Jose I. Suarez, Kazunori Toyoda, Haruko Yamamoto, on behalf of ATACH 2 Tri Tags: Statements and Guidelines, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Original Contributions Source Type: research
Association of White Matter Hyperintensities With Short-Term Outcomes in Patients With Minor Cerebrovascular Events Clinical Sciences
Conclusions—Our data suggest that quantitative and qualitative WML assessments are highly correlated and comparable in TIA/minor stroke patients. WML burden is associated with short-term outcome of patients with good prestroke function in the presence of intracranial stenosis/occlusion.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Charlotte Zerna, Amy Y.X. Yu, Jayesh Modi, Shiel K. Patel, Jonathan I. Coulter, Eric E. Smith, Shelagh B. Coutts Tags: Cerebrovascular Disease/Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Risk Factors for Poststroke Cognitive Decline Clinical Sciences
Background and Purpose—Poststroke cognitive decline causes disability. Risk factors for poststroke cognitive decline independent of survivors’ prestroke cognitive trajectories are uncertain.Methods—Among 22 875 participants aged ≥45 years without baseline cognitive impairment from the REGARDS cohort (Reasons for Geographic and Racial Differences in Stroke), enrolled from 2003 to 2007 and followed through September 2015, we measured the effect of incident stroke (n=694) on changes in cognitive functions and cognitive impairment (Six-Item Screener score
Source: Stroke - March 26, 2018 Category: Neurology Authors: Deborah A. Levine, Virginia G. Wadley, Kenneth M. Langa, Frederick W. Unverzagt, Mohammed U. Kabeto, Bruno Giordani, George Howard, Virginia J. Howard, Mary Cushman, Suzanne E. Judd, Andrzej T. Galecki Tags: Quality and Outcomes, Cognitive Impairment, Ischemic Stroke Original Contributions Source Type: research
Characteristics of Randomized Trials Focusing on Stroke due to Intracerebral Hemorrhage Clinical Sciences
Background and Purpose—The absence of treatments for intracerebral hemorrhage with significant consistent benefit in randomized controlled trials (RCTs) could be because of lack of treatment efficacy or the design of RCTs.Methods—We searched the Cochrane Stroke Group Trials Register in December 2015 for completed and published RCTs reporting clinical outcome in adults with intracerebral hemorrhage. We collected data on publication year and language, study characteristics, and effect size. We regarded RCTs to be at lower risk of bias if they performed ≥2 of describing randomization, using blinding, or specifying the p...
Source: Stroke - February 26, 2018 Category: Neurology Authors: Arina Tamborska, Michael T.C. Poon, Rustam Al-Shahi Salman Tags: Meta Analysis, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Original Contributions Source Type: research
Serum Hepatocyte Growth Factor Is Probably Associated With 3-Month Prognosis of Acute Ischemic Stroke Clinical Sciences
Background and Purpose—Serum hepatocyte growth factor (HGF) is positively associated with poor prognosis of heart failure and myocardial infarction, and it can also predict the risk of ischemic stroke in population. The goal of this study was to investigate the association between serum HGF and prognosis of ischemic stroke.Methods—A total of 3027 acute ischemic stroke patients were included in this post hoc analysis of the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). The primary outcome was composite outcome of death or major disability (modified Rankin Scale score ≥3) within 3 months.Results—Afte...
Source: Stroke - January 22, 2018 Category: Neurology Authors: Zhengbao Zhu, Tan Xu, Daoxia Guo, Xinfeng Huangfu, Chongke Zhong, Jingyuan Yang, Aili Wang, Chung-Shiuan Chen, Yanbo Peng, Tian Xu, Jinchao Wang, Yingxian Sun, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Yonghong Zhang, Jiang He Tags: Biomarkers, Clinical Studies, Epidemiology, Prognosis, Ischemic Stroke Original Contributions Source Type: research
Visual Aids for Patient, Family, and Physician Decision Making About Endovascular Thrombectomy for Acute Ischemic Stroke Clinical Sciences
Conclusions—Visual decision aids are now available to rapidly educate healthcare providers, patients, and families about benefits and risks of endovascular thrombectomy, both when added to IV tPA in tPA-eligible patients and as the sole reperfusion treatment in tPA-ineligible patients.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Ivie Tokunboh, Marta Vales Montero, Matheus Fellipe Zopelaro Almeida, Latisha Sharma, Sidney Starkman, Viktor Szeder, Reza Jahan, David Liebeskind, Nestor Gonzalez, Andrew Demchuk, Michael T. Froehler, Mayank Goyal, Maarten G. Lansberg, Helmi Lutsep, Lee Tags: Ischemia, Revascularization, Treatment, Quality and Outcomes, Ischemic Stroke Original Contributions Source Type: research
Serum Galectin-3 and Poor Outcomes Among Patients With Acute Ischemic Stroke Brief Report
Background and Purpose—Elevated galectin-3 has been associated with atherosclerosis and poor outcomes in patients with heart failure. However, it remains unclear whether galectin-3 has any effect on the poor outcomes of ischemic stroke. The aim of the present study was to examine the association between galectin-3 with poor outcomes among patients with acute ischemic stroke.Methods—Serum galectin-3 was measured in 3082 patients with acute ischemic stroke. The primary outcome was a combination of death or major disability (modified Rankin Scale score, ≥3) at 3 months after stroke.Results—Compared with the lowest qua...
Source: Stroke - December 22, 2017 Category: Neurology Authors: Aili Wang, Chongke Zhong, Zhengbao Zhu, Tian Xu, Yanbo Peng, Tan Xu, Hao Peng, Chung-Shiuan Chen, Jinchao Wang, Zhong Ju, Qunwei Li, Deqin Geng, Yingxian Sun, Jianhui Zhang, Xiaodong Yuan, Jing Chen, Yonghong Zhang, Jiang He Tags: Biomarkers, Clinical Studies, Cerebrovascular Disease/Stroke Brief Reports Source Type: research
No Racial Difference in Rehabilitation Therapy Across All Post-Acute Care Settings in the Year Following a Stroke Clinical Sciences
Background and Purpose—Black stroke survivors experience greater poststroke disability than whites. Differences in post-acute rehabilitation may contribute to this disparity. Therefore, we estimated racial differences in rehabilitation therapy utilization, intensity, and the number of post-acute care settings in the first year after a stroke.Methods—We used national Medicare data to study 186 168 elderly black and white patients hospitalized with a primary diagnosis of stroke in 2011. We tabulated the proportion of stroke survivors receiving physical, occupational, and speech and language therapy in each post-acute c...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Lesli E. Skolarus, Chunyang Feng, James F. Burke Tags: Health Services, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Thrombolysis in Postoperative Stroke Clinical Sciences
Conclusions—IVT may be administered safely in postoperative patients as off-label use after appropriate risk–benefit assessment. However, bleeding risk in surgical area should be taken into account particularly in patients who have undergone surgery shortly before stroke onset.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Nicolas Voelkel, Nikolai Dominik Hubert, Roland Backhaus, Roman Ludwig Haberl, Gordian Jan Hubert Tags: Complications, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Randomized Controlled Trial of Early Versus Delayed Statin Therapy in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions—Our randomized trial involving patients with acute ischemic stroke and dyslipidemia did not show any superiority of early statin therapy within 24 hours of admission compared with delayed statin therapy 7 days after admission to alleviate the degree of disability at 90 days after onset.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02549846.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Shinichi Yoshimura, Kazutaka Uchida, Takashi Daimon, Ryuzo Takashima, Kazuhiro Kimura, Takeshi Morimoto, on behalf of ASSORT Trial Investigator* Tags: Clinical Studies, Lipids and Cholesterol, Treatment, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Cost-Effectiveness of Thrombectomy in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions—Based on randomized trial data, this study demonstrates that IVMT used to treat acute ischemic stroke is cost-effective when compared with IVT alone.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01062698.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Hamza Achit, Marc Soudant, Kossar Hosseini, Aurelie Bannay, Jonathan Epstein, Serge Bracard, Francis Guillemin Tags: Cost-Effectiveness, Ischemic Stroke Original Contributions Source Type: research
