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In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke
Isr Med Assoc J. 2022 Dec 1;25(12):853-854.ABSTRACTEndovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in con...
Source: The Israel Medical Association Journal - August 16, 2023 Category: General Medicine Authors: Ze'ev Itsekson Hayosh Eiman Abu Bandora Natalia Shelestovich Maya Nulman Mati Bakon Gal Yaniv Boris Khaitovitch Shmuel Balan Alexandra Gerasimova Tali Drori Stefan Mausbach Yvonne Schwammenthal Arnon Afek Joab Chapman Efrat Shavit Stein David Orion Source Type: research

Append Medical Raises $4.35M in Initial Closing of Extended Series A Round
Funds will be used to complete the development of and support the First-in-Human Study of the Appligator™ for the Prevention of Stroke in Atrial Fibrillation Patients OR YEHUDA, Israel, July 6, 2023 -- (Healthcare Sales & Marketing Network) -- Append M... Devices, Interventional, Cardiology, Venture Capital Append Medical, Appligator, left atrial appendage, Atrial Fibrillation
Source: HSMN NewsFeed - July 6, 2023 Category: Pharmaceuticals Source Type: news

Safety Signal Evaluation of a Risk of Syncope and Dizziness Not Related to Bleeding or Stroke in Direct Oral Anticoagulant-Treated Patients
Clin Ther. 2023 Jan 16:S0149-2918(22)00416-7. doi: 10.1016/j.clinthera.2022.12.010. Online ahead of print.ABSTRACTPURPOSE: In clinical studies, rivaroxaban treatment has been associated with increased incidence of syncope not related to bleeding, anemia, or stroke. The study objective was to evaluate the occurrence of dizziness and/or syncope not related to bleeding, anemia, or stroke in patients treated with direct oral anticoagulants (DOACs).METHODS: A retrospective, observational, comparative study of adult patients diagnosed with atrial fibrillation and treated with DOACs was conducted using digital retrieval of medica...
Source: Clinical Therapeutics - January 18, 2023 Category: Drugs & Pharmacology Authors: Ophir Lavon Daisy Cohen Source Type: research

CHA2DS2-VASC Score Predicts the Risk of Stroke in Patients Hospitalized to the Internal Medicine Department Without Known Atrial Fibrillation
ConclusionsThe CHA2DS2-VASC score is a predictor for CVA/TIA during the first year after hospitalization in patients without AF. High CHA2DS2-VASC scores warrant work-up for occult AF/AFL and other risk factors for CVA/TIA.
Source: Journal of General Internal Medicine - May 27, 2022 Category: Internal Medicine Source Type: research

Management of Anticoagulation in Cancer Patients with Atrial Fibrillation
Isr Med Assoc J. 2022 Mar;24(3):183-185.ABSTRACTAtrial fibrillation is becoming an increasingly important problem in cardio-oncology. Specific risk factors for atrial fibrillation occurrence include type of cancer disease and anticancer drugs. Anticoagulation is often abandoned. The CHA2DS2-VASc and CHA2DS2 scores may be important not only in predicting stroke but also in mortality. The role of new direct oral anticoagulants is growing, but they need to be used in a personalized approach depending on the risk of unbeneficial interactions with cancer treatment and the risk of bleeding.PMID:35347933
Source: The Israel Medical Association Journal - March 29, 2022 Category: General Medicine Authors: Sebastian Szmit Jaros ław Kępski Michal Wilk Source Type: research

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