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Quantification of cardiac pumping mechanics in TAVI patients: A pilot study utilizing minimally invasive method for pressure ‐volume analysis
Reconstructed pressure volume loop by LV pressure and cardiac output. AbstractThe ventriculo-arterial coupling (VAC) and left ventricle (LV) mechanics are crucial and play an important role in the pathophysiology of aortic stenosis (AS). The pressure-volume (PV) analysis is a powerful tool to study VAC and LV mechanics. We proposed a novel minimally-invasive method for PV analysis in patients with severe AS receiving transcatheter aortic valve implantation (TAVI). Patients with severe AS were prospectively enrolled in a single center. LV pressure and cardiac output were recorded before and after TAVI. We constructed the PV...
Source: Physiological Reports - September 9, 2023 Category: Physiology Authors: Tsung ‐Yu Ko, Chia‐Chuan Chuang, Mao‐Shin Lin, Yi‐Chang Chen, Ying‐Hsien Chen, Ching‐Chang Huang, Chih‐Fan Yeh, Ming‐Jiuh Wang, Kuo‐Chu Chang, Yi‐Lwun Ho, Hsien‐Li Kao Tags: ORIGINAL ARTICLE Source Type: research

Physical and Physiologic Effects of Dobutamine Stress Echocardiography in Low-Gradient Aortic Stenosis
CONCLUSION: During DSE, aortic valve area increases with increase aortic valve gradient. Higher calcium score is associated with lower baseline aortic valve area, but the area valve area still increases with dobutamine even in presence of high calcium score.PMID:34860593 | DOI:10.1152/ajpheart.00183.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 3, 2021 Category: Physiology Authors: Kimi Sato Tom Kai Ming Wang Milind Y Desai Samir R Kapadia Amar Krishnaswamy L Leonardo Rodriguez Richard A Grimm Brian P Griffin Zoran B Popovic Source Type: research

Insights into the mechanism of paradoxical low-flow low-pressure-gradient severe aortic stenosis: association with reduced oxygen consumption by the whole body.
This study investigated the relationship between VO2, SVi and AS severity in patients with AS to examine the association between reduced VO2 and PLFLPG AS. In 59 patients (24 men, mean age 78±7 years) with severe AS, SVi, AS severity and type were evaluated by echocardiography, and VO2 was measured by the fraction of O2 in expired gases. The SVi and VO2 were significantly decreased in 20 patients with PLFLPG AS compared to those in 39 patients with non-PLFLPG AS (30±4 vs 41±7 ml/m2 and 2.4±0.5 vs 3.0±0.5 ml/min/kg, p < 0.01, respectively). The SVi to VO2 ratio was not different between the 2 groups (13.1±2.6 vs 13...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 25, 2019 Category: Physiology Authors: Onoue T, Iwataki M, Araki M, Itoh H, Isotani A, Umeda H, Fukuda S, Nagata Y, Tsuda Y, Fujino Y, Hanyu M, Ando K, Shirai S, Takeuchi M, Saeki S, Levine R, Otsuji Y Tags: Am J Physiol Heart Circ Physiol Source Type: research