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De Novo Sphingolipid Biosynthesis in Atherosclerosis
Adv Exp Med Biol. 2022;1372:31-46. doi: 10.1007/978-981-19-0394-6_3.ABSTRACTAtherosclerosis is the formation of fibrofatty lesions in the arterial wall, and this inflammatory state of the artery is the main cause of advanced pathological processes, including myocardial infarction and stroke. Dyslipidemic conditions with excess cholesterol accumulate within the arterial vessel wall and initiate atherogenic processes. Following vascular reaction and lipid accumulation, the vascular wall gradually thickens. Together with the occurrence of local inflammation, early atherosclerotic lesions lead to advanced pathophysiological ev...
Source: Atherosclerosis - May 3, 2022 Category: Cardiology Authors: Tae-Sik Park Shivani Devi Amitesh Sharma Goon-Tae Kim Kyung-Hee Cho Source Type: research

Drugs of Misuse: Focus on Vascular Dysfunction
Can J Cardiol. 2022 Apr 21:S0828-282X(22)00261-6. doi: 10.1016/j.cjca.2022.04.011. Online ahead of print.ABSTRACTCommon drugs of misuse, including cannabis, opioids, stimulants, alcohol, and anabolic steroids, have strikingly disparate acute and chronic vascular effects, leading to a wide range of clinical cardiovascular presentations. Acute cannabis smoking has been associated with increased risk for myocardial infarction and ischemic stroke in otherwise healthy young people. However, it remains uncertain if people who exclusively smoke cannabis have increased risk for accelerated atherosclerosis similar to that found in ...
Source: Atherosclerosis - April 24, 2022 Category: Cardiology Authors: Holly R Middlekauff Ziva D Cooper Sasha B Strauss Source Type: research

Correlation Between Carotid Intima Media Thickness and Non-Alcoholic Fatty Liver Disease
CONCLUSION: CIMT is increased in NAFLD patients. Increase in CIMT is significantly correlated with increasing grades of NAFLD. Hence CIMT can be used as screening tests in NALFD patients to assess cardiovascular risks.PMID:35443534
Source: Atherosclerosis - April 21, 2022 Category: Cardiology Authors: Shalini Kumari Y C Porwal Rohini Gupta Source Type: research

NAFLD increases Risk of Carotid Atherosclerosis and Ischemic Stroke. An Updated Meta-Analysis with 135,602 Individuals
CONCLUSIONS: This meta-analysis shows that a stepwise increment of steatosis of NAFLD can significantly increase the odds of carotid atherosclerosis and stroke development in NAFLD. More than a third suffer from carotid atherosclerosis and routine assessment of carotid atherosclerosis is quintessential in NAFLD.PMID:35232007 | DOI:10.3350/cmh.2021.0406
Source: Atherosclerosis - March 2, 2022 Category: Cardiology Authors: Ansel Shao Pin Tang Kai En Chan Jingxuan Quek Jieling Xiao Phoebe Tay Margaret Teng Keng Siang Lee Snow Yunni Lin May Zin Myint Benjamin Tan Vijay K Sharma Darren Jun Hao Tan Wen Hui Lim Apichat Kaewdech Daniel Huang Nicholas Ws Chew Mohammad Shadab Siddi Source Type: research

Non-alcoholic Fatty Liver Disease and Stroke: A Mendelian Randomization Study
CONCLUSION: This study suggested that the potential causal effect of NAFLD on ischemic stroke may be confined to the LAA and SVO subtypes.PMID:35147274 | DOI:10.1111/ene.15277
Source: Atherosclerosis - February 11, 2022 Category: Cardiology Authors: Min Wu Mingming Zha Qiushi Lv Yi Xie Kang Yuan Xiaohao Zhang Xinfeng Liu Source Type: research

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