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The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy < i > in vitro < /i > .
The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy <i>in vitro</i>. Phys Med Biol. 2019 Jun 12;: Authors: Kleven RT, Karani KB, Salido NG, Shekhar H, Haworth KJ, Mast TD, Tadesse DG, Holland CK Abstract Ultrasound-enhanced recombinant tissue plasminogen activator (rt-PA) thrombolysis is under development as an adjuvant to ischemic stroke therapy. The goal of this study was to design a pulsed ultrasound (US) exposure scheme that reduced intracranial constructive interference and tissue heating, and maintained thrombolytic efficacy relative to continuous wave (CW) insonat...
Source: Physics in Medicine and Biology - June 11, 2019 Category: Physics Authors: Kleven RT, Karani KB, Salido NG, Shekhar H, Haworth KJ, Mast TD, Tadesse DG, Holland CK Tags: Phys Med Biol Source Type: research