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The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy < i > in vitro < /i > .
The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy <i>in vitro</i>. Phys Med Biol. 2019 Jun 12;: Authors: Kleven RT, Karani KB, Salido NG, Shekhar H, Haworth KJ, Mast TD, Tadesse DG, Holland CK Abstract Ultrasound-enhanced recombinant tissue plasminogen activator (rt-PA) thrombolysis is under development as an adjuvant to ischemic stroke therapy. The goal of this study was to design a pulsed ultrasound (US) exposure scheme that reduced intracranial constructive interference and tissue heating, and maintained thrombolytic efficacy relative to continuous wave (CW) insonat...
Source: Physics in Medicine and Biology - June 11, 2019 Category: Physics Authors: Kleven RT, Karani KB, Salido NG, Shekhar H, Haworth KJ, Mast TD, Tadesse DG, Holland CK Tags: Phys Med Biol Source Type: research

Monitoring brain damage using bioimpedance technique in a 3D numerical model of the head.
In this study, the feasibility of basic electrical impedance technique for monitoring such damage was analyzed using a computerized model. Simulations were conducted on a realistic 3D numerical model of the head. Tissues were assumed to act as linear isotropic volume conductors, and the quasi-static approximation was applied. Electrical potentials were calculated by solving Poisson's equation, using the finite volume method and the successive over relaxation method. Left-right asymmetry was calculated for several conductivities and volumes of the damaged region. The results were compared with the left-right asymmetry in a ...
Source: Physica Medica - March 11, 2015 Category: Physics Authors: Cohen R, Abboud S, Arad M Tags: Med Eng Phys Source Type: research