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Risk of peripheral artery disease and stroke in migraineurs with or without aura: a nationwide population-based cohort study
Conclusion: Migraineurs without established cardiovascular disease had a significantly increased risk of PAD and stroke, and the risk of stroke persists in migraineurs with or without aura, with an increased trend of PAD in migraineurs with aura. Our study result should remind clinical physicians of the risk of PAD in the future among migraineurs even without established cardiovascular disease currently, and screening for PAD and stroke may be needed in caring patients with migraine.PMID:35919822 | PMC:PMC9339415 | DOI:10.7150/ijms.72119
Source: International Journal of Medical Sciences - August 3, 2022 Category: Biomedical Science Authors: Wun-Zhih Siao Chun-Hung Su Yu-Hsiang Kuan Tung-Han Tsai Kuang-Hua Huan Chien-Ying Lee Source Type: research

Thromboembolism in Patients with Hypertrophic Cardiomyopathy.
Authors: Liu L, Liu Z, Chen X, He S Abstract Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disease, which has a marked heterogeneity in clinical expression, natural history, and prognosis. HCM is associated with a high prevalence of thromboembolic events (stroke and systemic embolic events), even if taking no account of atrial fibrillation (AF), leading to unexpected disability and death in patients of all ages. Several risk factors of thromboembolism such as AF, greater age, left atrial diameter, heart failure and others have been confirmed in patients with HCM. Conventional thromboembolic predictive m...
Source: International Journal of Medical Sciences - January 14, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Caveolin-1 and MLRs: A potential target for neuronal growth and neuroplasticity after ischemic stroke.
Authors: Zhong W, Huang Q, Zeng L, Hu Z, Tang X Abstract Ischemic stroke is a leading cause of morbidity and mortality worldwide. Thrombolytic therapy, the only established treatment to reduce the neurological deficits caused by ischemic stroke, is limited by time window and potential complications. Therefore, it is necessary to develop new therapeutic strategies to improve neuronal growth and neurological function following ischemic stroke. Membrane lipid rafts (MLRs) are crucial structures for neuron survival and growth signaling pathways. Caveolin-1 (Cav-1), the main scaffold protein present in MLRs, targets man...
Source: International Journal of Medical Sciences - November 2, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research