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Specialty: Chemistry
Condition: Thrombosis
Drug: Plavix
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Total 1 results found since Jan 2013.
Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors.
CONCLUSION: These negative findings demonstrated that this heterocyclic nucleus is not a useful common pharmacophore for developing P2Y-dependent inhibitors of platelet aggregation. Nevetheless, compounds 2c and 2h could represent a new chemotype to further develop inhibitors of platelet aggregation.
PMID: 30734681 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - February 8, 2019 Category: Chemistry Authors: Cacciari B, Crepaldi P, Cheng CY, Bossi E, Spalluto G, Federico S, Jacobson KA, Cattaneo M Tags: Med Chem Source Type: research
