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A Novel Anti-Thrombotic, Glenzocimab, in Covid-19 acute respiratory distress syndrome (Cov-ARDS).
Conclusion: The GARDEN study was set up to tackle a global Public Health emergency. Glenzocimab was safe in doses three times higher than used in stroke. Albeit efficacy was not shown, overall, GARDEN provides insights into Cov-ARDS.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Pottecher, J., Sato, V. A. H., Pletan, Y., Comenducci, A., Desort-Henin, V., Jandrot-Perrus, M., Binay, S., Meilhoc, A., Avenard, G. Tags: 02.01 - Acute critical care Source Type: research

Risk contribution of comorbidities in hospitalized patients with Covid 19 pneumonia
Background: The Covid 19 pandemic has a vast socioeconomic impact worldwide. Obtaining information about the course of the disease is vital for better management.Aim: To assess the risk, comorbidities (CMs) and mortality in hospitalized patients with Covid 19 pneumonia.Methods: The information was gathered from the medical registry and statistical analysis was performed using SPSS.Results: A total of 337 patient were analyzed. Males were 197 (58,5%). Positive PCR results had 307 (91,1%) patients. Almost half of the patients were with respiratory failure on admission (47,1%). At least one comorbidity was found in 84,6%. Fro...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Kyuchukov, N., Krachunov, I., Ivanova, Z., Ignatova-Danova, T., Glogovska, P., Pavlov, P., Popova, T., Ivanov, Y. Tags: Respiratory infections and bronchiectasis Source Type: research

Thromboembolic events in COVID-19 patients : A Tunisian case series study
Coronavirus disease 2019 (COVID-19) can lead to systemic coagulation activation and thrombotic complications(TC), which may lead to fatal outcomes if not diagnosed and managed appropriately.We aimed to report the incidence and characteristics of venous and arterial thrombotic complications(TC) in hospitalized patients with COVID-19 and to investigate the predictive factors of their occurrence.A retrospective study including 200 patients with COVID-19 confirmed by a reverse transcription polymerase chain reaction test, admitted between March 2020 and January 2021 in the pulmonary departement B at Abderrahman Mami Hospi...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Louhaichi, S., Ferchichi, M., Khalfallah, I., Belkhir, S., Boubaker, N., Ammar, J., Hamdi, B., Hamzaoui, A. Tags: Respiratory infections and bronchiectasis Source Type: research

Controversies over the impact of the COVID-19 pandemic on patients with Pulmonary Arterial Hypertension
This study is a retrospective analysis of our PAH patients treated in 2020 compared to the dynamics of the last 12 years. We had 48 PAH patients, 51.72±16.64 years, 72.91% female. All patients had chronic anticoagulant therapy(58.33%) and/or antiplatelet; 33.33% had long term oxygen therapy. Three patients with secondary forms were confirmed with COVID-19, all hospitalized (6.25% infection rate versus 3.29% in general). One patient died(75 years with scleroderma, stroke), two patients were cured (mild forms). In total only three patients died in 2020. Surprisingly, compared with 2008-2019 (101 patients/ 41 deaths, 3...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Bertici, N. S., Dobrescu, L., Pislaru, L., Marincu, I. Tags: Pulmonary hypertension Source Type: research

Hypercoagulation as the main cause of death in COPD
Conclusion: In the literature there are many data on the main causes of death for patients with COPD, such as respiratory failure, lung cancer, pulmonary thromboembolism, but due to the high comorbidity of COPD with cardiovascular pathology, and the mechanism of mutual complications of these nosologies, according to our research, today the main causes of death for patients with COPD are cardiovascular accidents caused by hypercoagulation.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Abduganieva, E., Artikov, D., Liverko, I. Tags: Monitoring airway disease Source Type: research

The prognostic value of Red cell distribution width(RDW) in acute pulmonary thromboembolism
Conclusion: High RDW level is associated with higher 30 and 90 days mortality rate in acute PT patients. This marker could be considered as a valuable prognostic factor in acute PE.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Parsa, S., Hosseinvand, N., Peiman, S. Tags: Pulmonary embolism Source Type: research

Non-Contrast Chest CT Scans In Detection Of Pulmonary Thromboembolism
Conclusion: Non-contrast chest CT scans have good role in evaluation of PE through detection the hyperdense lumen sign that is a good indicator of acute pulmonary thromboembolism particularly in cases involving the central pulmonary arteries or peripheral wedge shaped opacity as useful indirect sign.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Shaaban, L., Othman, M. H. M., Abozaid, H., Mohamed, N. D. Tags: Pulmonary embolism Source Type: research

Risk of cardiovascular comorbidities in patients with idiopathic pulmonary fibrosis: Analysis of Medicare data
Conclusions: Newly diagnosed IPF pts are typically sicker than non-IPF pts and have significantly higher rates of CV conditions. The higher rate of CV conditions needs to be taken into consideration for the management and treatment of pts with IPF.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Broder, M., Change, E., Papoyan, E., Popescu, I., Reddy, S., Raimundo, K., Chou, W., Stauffer, J. Tags: 6.1 Epidemiology Source Type: research

The comparison of serum visfatin levels in patients with acute PTE and non-PTE independent of BMI
Conclusions: Although the serum visfatin levels were lower in the acute PTE group than in the non-PTE group both of which had similar BMI, the difference was not statistically significant. Further and larger studies are needed to evaluate the visfatin levels in acute PTE.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Tutar, N., Dogan, S., Buyukoglan, H., Sen, A., Yilmaz, I., Yildirim, A., Dogan, A., Yetkin, A., Oymak, F. s., Gulmez, I., Demir, R. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research